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1. 发明公开

EP3897740A1 NRTI THERAPIES 审中-公开
公开(公告)号：EP3897740A1
公开(公告)日：2021-10-27
申请号：EP19845779.8
申请日：2019-12-20
申请人： THE UNIVERSITY OF LIVERPOOL , The Johns Hopkins University
发明人： OWEN, Andrew , RANNARD, Steve , HERN, Faye , LIU, Chung , SHAKIL, Anika , NEARY, Megan , MEYERS, Caren Freel , TEMBURNIKAR, Kartik , BAMBARGER, Lauren , HENRIQUEZ, Stephanie
IPC分类号： A61K47/55 , A61K47/59 , A61K47/60 , A61K47/69 , A61P31/18

2. 发明公开

EP3008113A1 POLYDENDRONS 审中-公开
公开(公告)号：EP3008113A1
公开(公告)日：2016-04-20
申请号：EP14732325.7
申请日：2014-06-13
申请人： The University of Liverpool
发明人： RANNARD, Steven , OWEN, Andrew , ROGERS, Hannah , HATTON, Fiona , SOUTHWORTH, Faye
IPC分类号： C08G83/00 , A61K9/51 , C08F2/38 , C08F220/10 , C08F293/00
CPC分类号： C08F220/28 , A61K9/48 , A61K9/5138 , C08F2/38 , C08F220/10 , C08F220/34 , C08F293/005 , C08F2220/281 , C08F2220/286 , C08F2438/01 , C08G83/004 , C08F2222/1013
摘要： A method of preparing a pH-responsive non-gelled branched vinyl polymer scaffold carrying dendrons, comprismg the living or controlled polymerization of a mono functional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator.
摘要翻译：使用树枝状大分子引发剂制备携带树突的pH响应性非凝胶支化乙烯基聚合物支架的方法，其包括单官能乙烯基单体和双官能乙烯基单体的活性或受控聚合。

3. 发明公开

EP3497142A1 BRANCHED POLYMERS 审中-公开
公开(公告)号：EP3497142A1
公开(公告)日：2019-06-19
申请号：EP17761109.2
申请日：2017-08-08
申请人： The University of Liverpool
发明人： EDWARDS, Stephanie , RANNARD, Steve , OWEN, Andrew
IPC分类号： C08F220/28 , C08F2/38 , A61K9/10

4. 发明公开

EP3007727A1 POLYDENDRONS 审中-公开
公开(公告)号：EP3007727A1
公开(公告)日：2016-04-20
申请号：EP14732324.0
申请日：2014-06-13
申请人： The University of Liverpool
发明人： RANNARD, Steven , OWEN, Andrew , ROGERS, Hannah , GIARDIELLO, Marco , HATTON, Fiona , CHAMBON, Pierre , AUTY, Samuel , DWYER, Andrew , TATHAM, Lee
IPC分类号： A61K47/32 , A61K47/48 , B82Y30/00 , C08F2/38 , C08F220/28 , C08F222/10
CPC分类号： C08F2/38 , A61K9/5138 , A61K49/0028 , A61K49/0041 , A61K49/0054 , C08F220/28 , C08F220/58 , C08F222/1006 , C08F2438/01 , C08G83/002 , C08L2203/02
摘要： A method of preparing a non-gelled branched vinyl polymer scaffold carrying dendrons, comprising the living or controlled polymerization of a monofunctional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator and at least one further initiator.
摘要翻译：使用树枝状分子引发剂和至少一种其他引发剂制备带有树突的非胶凝支链乙烯基聚合物支架的方法，包括单官能乙烯基单体和双官能乙烯基单体的活性或受控聚合。

5. 发明公开

EP2753308A1 COMPOSITIONS OF LOPINAVIR AND RITONAVIR 有权
标题翻译： RUSONAVIR的ZUSAMMENSETZUNGEN AUS LOPINAVIR
公开(公告)号：EP2753308A1
公开(公告)日：2014-07-16
申请号：EP12758883.8
申请日：2012-09-07
申请人： The University of Liverpool
发明人： GIARDIELLO, Marco Norman , MCDONALD, Thomas Oliver , OWEN, Andrew , RANNARD, Steven Paul , MARTIN, Philip, John , SMITH, Darren, Lee
IPC分类号： A61K9/19 , A61K9/51 , A61K31/536
CPC分类号： A61K31/427 , A61K9/19 , A61K9/5138 , A61K9/5192 , A61K31/513 , A61K38/55 , Y02A50/411 , A61K2300/00
摘要： The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof. The present invention also relates to processes for preparing both the solid composition and the aqueous dispersion, as well as to their use in therapy for the treatment and/or prevention of retroviral infections such as human immunodeficiency virus (HIV).
摘要翻译：本发明涉及包含抗逆转录病毒药物洛匹那韦和利托那韦的纳米颗粒的固体组合物和水分散体。固体组合物和水分散体另外包含亲水性聚合物和表面活性剂的混合物。表面活性剂选自维生素E-聚乙二醇 - 琥珀酸酯（Vit-E-PEG-琥珀酸酯），聚氧乙烯脱水山梨醇脂肪酸酯，N-烷基二甲基苄基氯化铵，脱氧胆酸钠，二辛基磺基琥珀酸钠，聚乙二醇12-羟基硬脂酸酯，聚乙烯醇（PVA）和聚氧乙烯和聚氧丙烯的嵌段共聚物，或其组合。亲水性聚合物适当地选自聚乙烯醇（PVA），聚乙烯醇 - 聚乙二醇接枝共聚物，聚氧乙烯和聚氧丙烯的嵌段共聚物，聚乙二醇，羟丙基甲基纤维素（HPMC）和聚乙烯吡咯烷酮或其组合。本发明还涉及制备固体组合物和水性分散体的方法，以及它们在治疗和/或预防逆转录病毒感染如人类免疫缺陷病毒（HIV）中的用途。

6. 发明公开

EP4419073A1 SOLID COMPOSITIONS COMPRISING TENOFOVIR ALAFENAMIDE AND/OR BICTEGRAVIR 审中-实审
公开(公告)号：EP4419073A1
公开(公告)日：2024-08-28
申请号：EP22797827.7
申请日：2022-10-20
申请人： The University Of Liverpool
发明人： RANNARD, Steven Paul , OWEN, Andrew , HOBSON, James , SAVAGE, Alison , BARLOW, Eleanor , CURLEY, Paul , SHARP, Joanne , DONNELLY, Ryan , ZHANG, Chunyang , WU, Yu
IPC分类号： A61K9/00 , A61K9/16 , A61K31/00 , A61P31/00
CPC分类号： A61K9/0021 , A61K9/0024 , A61K9/1635 , A61K9/1652 , A61K9/1623 , A61K9/1617 , A61K9/0019 , A61P31/00 , A61K31/675 , A61K31/553

7. 发明公开

EP3600245A1 METHOD FOR PRODUCING A LIQUID COMPOSITION 审中-公开
公开(公告)号：EP3600245A1
公开(公告)日：2020-02-05
申请号：EP18715946.2
申请日：2018-03-29
申请人： The University of Liverpool , The Johns Hopkins University
发明人： RANNARD, Steven Paul , OWEN, Andrew , CURLEY, Paul , HOBSON, James , SICCARDI, Marco , FREEL MEYERS, Caren L. , AL-KHOUJA, Amer , MEYERS, David J. , FLEXNER, Charles Williams
IPC分类号： A61K9/00 , A61K47/14 , A61K9/08 , A61K47/44 , A61K9/14 , A61K9/19 , A61K9/48 , A61K31/675

8. 发明公开

EP3471697A1 CHEMICAL COMPOSITION 有权
公开(公告)号：EP3471697A1
公开(公告)日：2019-04-24
申请号：EP17736703.4
申请日：2017-06-15
申请人： The University of Liverpool , The Johns Hopkins University
发明人： RANNARD, Steven Paul , OWEN, Andrew , SAVAGE, Alison , TATHAM, Lee , SHAPIRO, Theresa , BAKSHI, Rahul P. , MLAMBO, Godfree , TRIPATHI, Abhai
IPC分类号： A61K9/00 , A61K9/14 , A61K9/19 , A61K31/155

9. 发明公开

EP3253371A1 NANOEMULSIONS 有权
标题翻译：纳米乳液
公开(公告)号：EP3253371A1
公开(公告)日：2017-12-13
申请号：EP16703830.6
申请日：2016-02-03
申请人： The University of Liverpool
发明人： RANNARD, Steve , OWEN, Andrew , HOBSON, James , LIPTROTT, Neill , CHAMBON, Pierre
IPC分类号： A61K9/107 , A61K47/10 , A61K47/34 , C08F220/20
CPC分类号： A61K9/1641 , A61K9/0053 , A61K9/107 , A61K9/1075 , A61K31/513 , A61K31/536 , A61K47/10 , A61K47/34 , B01F17/0028 , C08F220/28 , C08F2220/286 , C08F2438/01 , C08F2222/1013
摘要： An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. The oil phase may comprise a further solvent which is miscible with the oil, said solvent being allowed to evaporate to produce the final emulsion.

10. 发明公开

EP3758683A1 SOLID COMPOSITIONS OF ACTIVES, PROCESSES FOR PREPARING SAME AND USES OF SUCH SOLID COMPOSITIONS 无效
公开(公告)号：EP3758683A1
公开(公告)日：2021-01-06
申请号：EP19710119.9
申请日：2019-03-04
申请人： THE UNIVERSITY OF LIVERPOOL
发明人： RANNARD, Steven Paul , OWEN, Andrew , SAVAGE, Alison , TATHAM, Lee , DWYER, Andrew , BOX, Helen , SHARP, Joanne , ASHCROFT, Samantha
IPC分类号： A61K9/16 , A61K31/4402 , A61K31/46 , A61P31/18

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