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1. 发明公开

EP4285998A2 GLYCOLIPIDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR USE IN THERAPY 审中-实审
公开(公告)号：EP4285998A2
公开(公告)日：2023-12-06
申请号：EP23182534.0
申请日：2015-04-07
申请人： The University of Nottingham
发明人： BOTLEY, Andrew , HAYES, Christopher , SEYMOUR, Graham , GRABAWSKA, Anna , CLARKE, Philip
IPC分类号： A61P21/00
摘要： A compound of Formula I:

R1-L1-C(A)(A') - CH 2 - L2-R2 (I)

or a pharmaceutically acceptable salt thereof,
for use in medicine, for example in the treatment of a disease or condition selected from the group comprising cancer, autistic spectrum disorders, Alzheimer's disease, Parkinson's disease, Huntingdon's disease, muscle wasting and viral infection,
wherein:
R1 is selected from a carbohydrate group or derivative thereof, hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group;
L1 is a linking group;
L2 is a linking group;
R2 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group;
A is selected from hydrogen and a C1-C6 alkyl group;
A' is selected from hydrogen, a C1-C6 alkyl group, and L3-R3; wherein
L3 is a linking group; and
R3 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group;
and wherein if A' is not L3-R3, then R2 is a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group;
and wherein if A' is L3-R3, then one or both of R2 and R3 are a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group.

2. 发明公开

EP4285998A3 GLYCOLIPIDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR USE IN THERAPY 审中-实审
公开(公告)号：EP4285998A3
公开(公告)日：2024-02-14
申请号：EP23182534.0
申请日：2015-04-07
申请人： The University of Nottingham
发明人： BOTLEY, Andrew , HAYES, Christopher , SEYMOUR, Graham , GRABAWSKA, Anna , CLARKE, Philip
IPC分类号： A61K31/7024 , A61K45/06 , A61K31/7032 , A61K33/24 , C07H3/02 , A61P35/00 , A61P25/16 , A61P25/28 , A61P25/00 , A61P31/12 , A61P21/00
摘要： A compound of Formula I:

R1-L1-C(A)(A') - CH 2 - L2-R2 (I)

or a pharmaceutically acceptable salt thereof,
for use in medicine, for example in the treatment of a disease or condition selected from the group comprising cancer, autistic spectrum disorders, Alzheimer's disease, Parkinson's disease, Huntingdon's disease, muscle wasting and viral infection,
wherein:
R1 is selected from a carbohydrate group or derivative thereof, hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group;
L1 is a linking group;
L2 is a linking group;
R2 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group;
A is selected from hydrogen and a C1-C6 alkyl group;
A' is selected from hydrogen, a C1-C6 alkyl group, and L3-R3; wherein
L3 is a linking group; and
R3 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group;
and wherein if A' is not L3-R3, then R2 is a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group;
and wherein if A' is L3-R3, then one or both of R2 and R3 are a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group.

3. 发明公开

EP3129057A1 GLYCOLIPIDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR USE IN THERAPY 有权
标题翻译： GLYKOLIPIDE UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DARAUS ZUR VERWENDUNG IN DER THERAPIE
公开(公告)号：EP3129057A1
公开(公告)日：2017-02-15
申请号：EP15717051.5
申请日：2015-04-07
申请人： The University Of Nottingham
发明人： BOTTLEY, Andrew , HAYES, Christopher , SEYMOUR, Graham , GRABAWSKA, Anna , CLARKE, Philip
IPC分类号： A61K45/06 , A61K31/7032 , A61K33/24 , C07H3/02 , A61P35/00 , A61P25/16 , A61P25/28 , A61P25/00 , A61P31/12 , A61P21/00
CPC分类号： C07H15/06 , A23L33/16 , A23L33/30 , A23V2002/00 , A61K31/7032 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： A compound of Formula I: R1 -L1 -C(A)(A') - CH
2 , - L2-R2 or a pharmaceutically acceptable salt thereof, for use in medicine, for example in the treatment of a disease or condition selected from the group comprising cancer, autistic spectrum disorders. Alzheimer' s disease, Parkinson's disease, Huntingdon' s disease, muscie wasting and viral infection, wherein: R1 is selected from a carbohydrate group or derivative thereof, hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an aikenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; L1 is a linking group; L2 is a linking group; R2 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; A is selected from hydrogen and a C1 -C6 alkyl group: A' is selected from hydrogen, a C3 -C6 alkyl group, and L3-R3; wherein L3 is a linking group; and R3 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group; and wherein if A' is not L3-R3, then R2 is a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group; and wherein if A' is L3-R3, then one or both of R2 and R3 are a C10-C24 alkyl or a C10-C24 derivative of an alkyl group, a C10-C24 alkenyl or a C10-C24 derivative of an alkenyl group, or a C10-C24 alkynyl group or a C10-C24 derivative of an alkynyl group.
摘要翻译：式I的化合物：R 1 -L 1 -C（A）（A'）-CH 2，-L 2 -R 2或其药学上可接受的盐，用于医学中，例如用于治疗选自以下的疾病或病症：组包括癌症，自闭症谱系障碍。阿尔茨海默氏病，帕金森病，亨廷顿氏病，肌肉消瘦和病毒感染，其中：R1选自碳水化合物基团或其衍生物，氢，烷基的C 1 -C 24烷基或C 1 -C 24衍生物，链烯基的C2-C24链烯基或C2-C24衍生物，炔基的C2-C24炔基或C2-C24衍生物; L1是连接基团; L2是连接基团; R2选自氢，C 1 -C 24烷基或C 1 -C 24衍生物，C 2 -C 24链烯基或链烯基的C 2 -C 24衍生物，以及C 2 -C 24炔基或C 2 -C 24 炔基的衍生物; A选自氢和C 1 -C 6烷基：A'选自氢，C 3 -C 6烷基和L 3 -R 3; 其中L3是连接基团; 并且R 3选自氢，C 1 -C 24烷基或C 1 -C 24衍生物的烷基，C 2 -C 24烯基或C 2 -C 24衍生物的烯基，以及C 2 -C 24炔基或C 2 -C 24炔基，炔基的C24衍生物; 并且其中如果A'不是L3-R3，那么R 2是烷基的C 10 -C 24烷基或C 10 -C 24衍生物，链烯基的C 10 -C 24烯基或C 10 -C 24衍生物或C10- C24炔基或炔基的C10-C24衍生物; 并且其中如果A'是L3-R3，那么R 2和R 3中的一个或两个是C 1 -C 24烷基或C 1 -C 24烷基的C 10 -C 24衍生物，链烯基的C 10 -C 24烯基或C 10 -C 24衍生物，或C10-C24炔基或炔基的C10-C24衍生物。

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