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1. 发明公开

EP1750500A2 NGAL FOR REDUCTION AND AMELIORATION OF ISCHEMIC AND NEPHROTOXIC INJURIES 有权
标题翻译： NGAL ZUR VERRINGERUNG UND VERBESSERUNG VONISCHÄMISCHENUND NEPHROTOXISCHENSCHÄDEN
公开(公告)号：EP1750500A2
公开(公告)日：2007-02-14
申请号：EP05749675.4
申请日：2005-05-06
申请人： The Trustees of Columbia University in the City of New York , Children's Hospital Medical Center
发明人： BARASCH, Jonathan, M. , DEVARAJAN, Prasad , MORI, Kiyoshi
IPC分类号： A01N1/00
CPC分类号： G01N33/6893 , A01N1/0226 , A61K38/1709 , A61K39/025 , G01N33/74 , G01N2333/47 , G01N2800/347 , A61K2300/00
摘要： Use of neutrophil gelatinase-associated lipocalin (NGAL) as a therapeutic and in a method of treating, reducing, or ameliorating an injury selected from an ischemic injury, an ischemic-reperfusion injury, and a toxin-induced injury, to an organ in a patient. The invention includes administering to the patient NGAL in an amount effective to treat, reduce or ameliorate ischemic, ischemic-reperfusion, or toxin-induced injury to the organ, such as the kidney. A siderophore can be co-administered with the NGAL. The invention also relates to administering a sideophore to enhance a response to secretion of NGAL following an ischemic or toxin-induced injury to an organ in a patient.
摘要翻译：使用嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）作为治疗剂和治疗，减少或改善选自缺血性损伤，缺血再灌注损伤和毒素诱导的损伤的损伤的方法，患者。本发明包括以有效治疗，减轻或改善对器官如肾脏的缺血性，缺血再灌注或毒素诱导的损伤的量给予患者NGAL。铁载体可与NGAL共同施用。本发明还涉及在对患者的器官发生缺血或毒素诱导的损伤之后，给予视力模型以增强对NGAL分泌的反应。

2. 发明授权

EP1750500B1 NGAL FOR REDUCTION AND AMELIORATION OF ISCHEMIC AND NEPHROTOXIC INJURIES 有权
标题翻译： NGAL还原与缺血和损害肾毒性的改进
公开(公告)号：EP1750500B1
公开(公告)日：2015-07-08
申请号：EP05749675.4
申请日：2005-05-06
申请人： The Trustees of Columbia University in the City of New York , Children's Hospital Medical Center
发明人： BARASCH, Jonathan M. , DEVARAJAN, Prasad , MORI, Kiyoshi
IPC分类号： A61K38/17
CPC分类号： G01N33/6893 , A01N1/0226 , A61K38/1709 , A61K39/025 , G01N33/74 , G01N2333/47 , G01N2800/347 , A61K2300/00

3. 发明公开

EP1946105A2 DIAGNOSIS AND MONITORING OF CHRONIC RENAL DISEASE USING NGAL 审中-公开
标题翻译：诊断和慢性肾脏疾病使用的NGAL监测
公开(公告)号：EP1946105A2
公开(公告)日：2008-07-23
申请号：EP06816888.9
申请日：2006-10-13
申请人： Children's Hospital Medical Center , The Trustees of Columbia University
发明人： BARASCH, Jonathan, M. , DEVARAJAN, Prasad , NICKOLAS, Thomas, L. , MORI, Kiyoshi
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52
摘要： A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as over time. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening chronic renal disease or CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.

4. 发明公开

EP1946107A2 DIAGNOSIS AND MONITORING OF CHRONIC RENAL DISEASE USING NGAL 有权
标题翻译：用NGAL诊断和监测慢性肾脏疾病
公开(公告)号：EP1946107A2
公开(公告)日：2008-07-23
申请号：EP06826191.6
申请日：2006-10-13
申请人： Children's Hospital Medical Center , The Trustees of Columbia University
发明人： BARASCH, Jonathan, M. , DEVARAJAN, Prasad , NICKOLAS, Thomas, L. , MORI, Kiyoshi
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52
摘要： A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as over time. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening chronic renal disease or CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF.
摘要翻译：通过检测尿液，血清或血浆中嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的量，评估患有或有发生慢性肾损伤或疾病风险（包括慢性肾衰竭（CRF））的哺乳动物的进行性肾脏状态的方法在不连续的时间段以及随着时间推移的样本。慢性肾功能衰竭患者长时间NGAL水平增加可以诊断肾脏疾病恶化。 NGAL的这种升高与慢性肾脏疾病或CRF恶化的其他指标有关，例如血清肌酐升高，尿蛋白分泌增加以及肾小球滤过率（GFR）下降。通过患者治疗前和治疗后NGAL水平证实，适当检测恶化（或改善，如果已经开始治疗）随时间变化的肾状态可帮助临床医师设计和/或维持适当的治疗方案以减缓或停止CRF的进展。

5. 发明授权

EP1946107B1 DIAGNOSIS AND MONITORING OF CHRONIC RENAL DISEASE USING NGAL 有权
标题翻译：诊断和慢性肾脏疾病使用的NGAL监测
公开(公告)号：EP1946107B1
公开(公告)日：2015-02-25
申请号：EP06826191.6
申请日：2006-10-13
申请人： Children's Hospital Medical Center , The Trustees of Columbia University
发明人： BARASCH, Jonathan, M. , DEVARAJAN, Prasad , NICKOLAS, Thomas, L. , MORI, Kiyoshi
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52

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