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1. 发明公开

EP4414022A2 IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS 审中-实审
公开(公告)号：EP4414022A2
公开(公告)日：2024-08-14
申请号：EP24171937.6
申请日：2017-07-07
申请人： The Regents of the University of California
发明人： MAHARBIZ, Michel M. , CARMENA, Jose M. , ANWAR, Mekhail , OZILGEN, Burak A. , SEO, Dongjin , FAVA, Federica
IPC分类号： A61N1/05
CPC分类号： A61B6/4258 , A61N1/3787 , A61B8/0875 , A61B8/48 , A61B5/0031 , A61B5/076 , A61N1/0534 , A61N1/3605 , A61N1/37205 , A61N5/1071 , A61N2005/108720130101 , A61B5/686 , A61B2505/0520130101 , A61B2560/021920130101 , A61B2562/02820130101 , A61B2562/1220130101 , A61B8/085
摘要： Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

2. 发明授权

EP3481285B1 IMPLANTS USING ULTRASONIC WAVES FOR STIMULATING TISSUE 有权
公开(公告)号：EP3481285B1
公开(公告)日：2020-09-30
申请号：EP17743117.8
申请日：2017-07-07
申请人： The Regents of the University of California
发明人： MAHARBIZ, Michel M. , SEO, Dongjin , SHEN, Konlin , CARMENA, Jose M. , NEELY, Ryan , ALON, Elad , RABAEY, Jan
IPC分类号： A61B5/00 , A61N1/36 , A61N1/378 , A61N1/372 , A61N1/05

3. 发明公开

EP4414022A3 IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS 审中-实审
公开(公告)号：EP4414022A3
公开(公告)日：2024-10-30
申请号：EP24171937.6
申请日：2017-07-07
申请人： The Regents of the University of California
发明人： MAHARBIZ, Michel M. , CARMENA, Jose M. , ANWAR, Mekhail , OZILGEN, Burak A. , SEO, Dongjin , FAVA, Federica
IPC分类号： A61B8/08 , A61B5/03 , A61B5/02 , A61N1/05 , A61N5/10
CPC分类号： A61B6/4258 , A61N1/3787 , A61B8/0875 , A61B8/48 , A61B5/0031 , A61B5/076 , A61N1/0534 , A61N1/3605 , A61N1/37205 , A61N5/1071 , A61N2005/108720130101 , A61B5/686 , A61B2505/0520130101 , A61B2560/021920130101 , A61B2562/02820130101 , A61B2562/1220130101 , A61B8/085 , A61B8/0808 , A61B8/00 , A61B8/4483 , A61B8/04 , A61B8/56 , A61B8/12
摘要： Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

4. 发明公开

EP4034227A1 PERIPHERAL BRAIN-MACHINE INTERFACE SYSTEM VIA VOLITIONAL CONTROL OF INDIVIDUAL MOTOR UNITS 无效
公开(公告)号：EP4034227A1
公开(公告)日：2022-08-03
申请号：EP20869051.1
申请日：2020-09-24
申请人： The Regents of the University of California
发明人： CARMENA, Jose M. , FORMENTO, Emanuele , BOTROS, Paul Abraham , MAHARBIZ, Michel M.
IPC分类号： A61N1/36 , A61B5/389 , A61B5/375 , A61B5/00 , A61F2/72 , A61F4/00 , G06F3/01

5. 发明公开

EP3795067A1 IMPLANTS USING ULTRASONIC WAVES FOR STIMULATING TISSUE 有权
公开(公告)号：EP3795067A1
公开(公告)日：2021-03-24
申请号：EP20198662.7
申请日：2017-07-07
申请人： The Regents of the University of California
发明人： MAHARBIZ, Michel M. , SEO, Dongjin , SHEN, Konlin , CARMENA, Jose M. , NEELY, Ryan , ALON, Elad , RABAEY, Jan
IPC分类号： A61B5/00 , A61N1/36 , A61N1/378 , A61N1/372 , A61N1/05
摘要： Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating one or more implantable devices, as well as methods of electrically stimulating a tissue.

6. 发明公开

EP3481287A2 IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS 有权转让
公开(公告)号：EP3481287A2
公开(公告)日：2019-05-15
申请号：EP17791765.5
申请日：2017-07-07
申请人： The Regents of the University of California
发明人： MAHARBIZ, Michel M. , CARMENA, Jose M. , ANWAR, Mekhail , OZILGEN, Burak A. , SEO, Dongjin , FAVA, Federica
IPC分类号： A61B5/00 , A61N1/36 , A61N1/378 , A61N1/372 , A61N1/05

7. 发明公开

EP3481285A1 IMPLANTS USING ULTRASONIC WAVES FOR STIMULATING TISSUE 有权
公开(公告)号：EP3481285A1
公开(公告)日：2019-05-15
申请号：EP17743117.8
申请日：2017-07-07
申请人： The Regents of the University of California
发明人： MAHARBIZ, Michel M. , SEO, Dongjin , SHEN, Konlin , CARMENA, Jose M. , NEELY, Ryan , ALON, Elad , RABAEY, Jan
IPC分类号： A61B5/00 , A61N1/36 , A61N1/378 , A61N1/372 , A61N1/05
摘要： Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

8. 发明公开

EP3237058A2 METHODS, COMPOSITIONS, AND SYSTEMS FOR DEVICE IMPLANTATION 有权
标题翻译：用于装置植入的方法，组合物和系统
公开(公告)号：EP3237058A2
公开(公告)日：2017-11-01
申请号：EP15881408.7
申请日：2015-12-18
申请人： The Regents of the University of California
发明人： HANSON, Timothy L. , MAHARBIZ, Michel M. , SABES, Philip N.
IPC分类号： A61N1/05
CPC分类号： A61B17/3468 , A61B2017/00526 , A61N1/0531 , A61N1/0534 , A61N5/0601 , A61N5/0622 , A61N2005/063
摘要： Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.
摘要翻译：提供了用于将可植入装置植入生物组织（例如，肌肉，大脑）中的方法，系统和组合物。主题可植入装置包括：（i）生物相容性基底，（ii）设置在生物相容性基底上的导管（例如，电极，波导），和（iii）用于可逆的接合特征（例如环）与插入针接合。生物相容性基底可以是柔性的（例如，可以包括聚酰亚胺）。使用插入针植入可植入装置，插入针包括对应于可植入装置的接合特征的接合特征。为了植入，可植入装置与插入针可逆地接合，将装置装载的插入针插入到生物组织中（例如，达到期望的深度），并且插入针缩回，由此使可植入装置从插入脱离针并允许植入式装置保持植入生物组织中。

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