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1. 发明公开

EP2467062A2 DISPOSABLE ACOUSTIC COUPLING MEDIUM CONTAINER 有权
标题翻译：声学耦合一次性媒体设备
公开(公告)号：EP2467062A2
公开(公告)日：2012-06-27
申请号：EP10810498.5
申请日：2010-08-17
申请人： Histosonics, Inc. , The Regents Of The University Of Michigan
发明人： JAHNKE, Russell , BERTOLINA, James , ROBERTS, William , CAIN, Charles , TEOFILOVIC, Dejan , DAVISON, Thomas, W.
IPC分类号： A61B8/14 , A61N7/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2251 , A61B17/2256 , A61B2017/00274 , A61B2017/2253 , A61B2018/00547 , A61B2090/378 , A61N2007/0039 , A61N2007/0043
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

2. 发明公开

EP4166194A1 HISTOTRIPSY EXCITATION SEQUENCES OPTIMIZED FOR BUBBLE CLOUD FORMATION USING SHOCK SCATTERING 审中-实审
公开(公告)号：EP4166194A1
公开(公告)日：2023-04-19
申请号：EP22213038.7
申请日：2014-07-03
申请人： Histosonics, Inc. , The Regents of The University of Michigan
发明人： CANNATA, Jonathan , HALL, Timothy L. , MAXWELL, Adam , TEOFILOVIC, Dejan
IPC分类号： A61N7/00 , A61B8/00 , A61B17/22
摘要： Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 µs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.

3. 发明授权

EP2467062B1 DISPOSABLE ACOUSTIC COUPLING MEDIUM CONTAINER 有权
标题翻译：声学耦合一次性媒体设备
公开(公告)号：EP2467062B1
公开(公告)日：2017-01-18
申请号：EP10810498.5
申请日：2010-08-17
申请人： Histosonics, Inc. , The Regents of The University of Michigan
发明人： JAHNKE, Russell , BERTOLINA, James , ROBERTS, William , CAIN, Charles , TEOFILOVIC, Dejan , DAVISON, Thomas, W.
IPC分类号： A61B8/14 , A61N7/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2251 , A61B17/2256 , A61B2017/00274 , A61B2017/2253 , A61B2018/00547 , A61B2090/378 , A61N2007/0039 , A61N2007/0043

4. 发明公开

EP3016594A1 HISTOTRIPSY EXCITATION SEQUENCES OPTIMIZED FOR BUBBLE CLOUD FORMATION USING SHOCK SCATTERING 有权
标题翻译： FÜRBLASENWOLKENBILDUNG MIT SCHOCKSTREUUNG OPTIMIERTE HISTOTRIPSIE-ERREGUNGSSEQUENZEN
公开(公告)号：EP3016594A1
公开(公告)日：2016-05-11
申请号：EP14819742.9
申请日：2014-07-03
申请人： Histosonics, Inc. , The Regents of The University of Michigan
发明人： CANNATA, Jonathan , HALL, Timothy L. , MAXWELL, Adam , TEOFILOVIC, Dejan
IPC分类号： A61B8/00
CPC分类号： A61N7/00 , A61B17/22004 , A61B17/225 , A61B2017/00176 , A61B2017/22008 , A61B2017/22028 , A61N2007/0039 , A61N2007/0078
摘要： Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.
摘要翻译：提供了用于在组织中产生空化的方法和装置。在一个实施例中，组织破坏治疗的冲击散射方法包括将起始压力波形从超声治疗换能器输送到组织中，起始压力波形被配置为在组织中产生至少一个气泡，从超声治疗中输送散射压力波形换能器进入所述至少一个气泡的生命周期内的所述至少一个气泡中，并且用所述散射压力波形在所述至少一个气泡附近产生气蚀核。散射压力波形可在至少一个气泡的生命周期内传送。在一些实施例中，散射压力波形在起始压力波形的5μs至1s内传送。还讨论了用于进行休克散射的系统组织切除术治疗。

5. 发明授权

EP2470267B1 MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 有权
标题翻译：微机器人控制臂的治疗和成像的超声波转换器
公开(公告)号：EP2470267B1
公开(公告)日：2015-11-11
申请号：EP10814299.3
申请日：2010-08-26
申请人： The Regents of The University of Michigan , Histosonics, Inc.
发明人： ROBERTS, William, W. , HALL, Timothy, L. , CAIN, Charles, A. , FOWLKES, J., Brian , XU, Zhen , KUSNER, Michael, Thomas, Jr. , TEOFILOVIC, Dejan
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
CPC分类号： A61N7/02 , A61B8/12 , A61B8/4218 , A61B34/72 , A61B90/50 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

6. 发明公开

EP2470267A2 MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 有权
标题翻译：微机器人控制臂的治疗和成像的超声波转换器
公开(公告)号：EP2470267A2
公开(公告)日：2012-07-04
申请号：EP10814299.3
申请日：2010-08-26
申请人： The Regents Of The University Of Michigan , Histosonics, Inc.
发明人： ROBERTS, William, W. , HALL, Timothy, L. , CAIN, Charles, A. , FOWLKES, J., Brian , XU, Zhen , KUSNER, Michael, Thomas, Jr. , TEOFILOVIC, Dejan
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
CPC分类号： A61N7/02 , A61B8/12 , A61B8/4218 , A61B34/72 , A61B90/50 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

7. 发明公开

EP3886737A1 HISTOTRIPSY SYSTEMS AND METHODS 审中-公开
公开(公告)号：EP3886737A1
公开(公告)日：2021-10-06
申请号：EP19891496.2
申请日：2019-11-27
申请人： Histosonics, Inc.
发明人： CANNATA, Jonathan, M. , MILLER, Ryan , DURYEA, Alexander, P. , TEOFILOVIC, Dejan , MLADENOVIC, Zeljko , RAKIC, Aleksandra , STOPEK, Joshua
IPC分类号： A61B17/22 , A61B8/00 , A61B17/225 , A61B90/00 , A61N7/00

8. 发明公开

EP2836871A1 SYSTEMS AND METHODS FOR OBTAINING LARGE CREEPAGE ISOLATION ON PRINTED CIRCUIT BOARDS 审中-公开
标题翻译：用于在印刷电路板上获得大型蠕变隔离的系统和方法
公开(公告)号：EP2836871A1
公开(公告)日：2015-02-18
申请号：EP13775051.9
申请日：2013-04-11
申请人： Histosonics, Inc.
发明人： TEOFILOVIC, Dejan
IPC分类号： G02B26/00
CPC分类号： H05K1/0256 , H05K1/0227 , H05K2201/0761 , H05K2201/09781 , H05K2201/09972 , H05K2201/10121
摘要： An electrical circuit with large creepage isolation distances is provided. In some embodiments, the electrical circuit is capable of increasing creepage isolation distances by many multiples over traditional electrical circuits. In one embodiment, an electrical circuit comprises a ground circuit optically coupled to a floating circuit, and an isolated circuit optically coupled to the floating circuit. The circuits can be optically coupled with opto-isolators, for example. The isolated circuit can have a creepage isolation distance at least twice as large as a traditional circuit. In some embodiments, "n" number of floating circuits can be optically coupled between the ground circuit and the isolated circuit to increase the total creepage isolation distance by a factor of "n". Methods of use are also described.
摘要翻译：提供具有大爬电距离的电路。在一些实施例中，电路能够将传统电路上的爬电距离隔离距离增加许多倍。在一个实施例中，电路包括光耦合到浮动电路的接地电路以及光耦合到浮动电路的隔离电路。例如，电路可以与光隔离器光耦合。隔离电路的爬电距离至少是传统电路的两倍。在一些实施例中，“n”个浮动电路可以光耦合在接地电路和隔离电路之间，以将总爬电距离隔离距离增加“n”倍。还描述了使用方法。

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