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1. 发明公开

EP1572867A2 ENDOTHELIAL CELL EXPRESSION PATTERNS 有权
标题翻译：内皮细胞表达模式
公开(公告)号：EP1572867A2
公开(公告)日：2005-09-14
申请号：EP02728495.9
申请日：2002-04-10
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： CARSON-WALTER, Eleanor , ST. CROIX, Brad , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
IPC分类号： C12N1/00
CPC分类号： C07K14/705 , A61K2039/505 , C07K14/4748 , C07K16/28 , G01N33/5023 , G01N33/68 , G01N2333/4703 , G01N2500/04 , G01N2800/7014 , G01N2800/7028
摘要： To gain a better understanding of tumor angiogenesis, new techniques for isolating endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed 79 differentially expressed genes, including 46 that were specifically elevated in tumor-associated endothelium. Experiments with representative genes from this group demonstrated that most were similarly expressed in the endothelium of primary lung, breast, brain, and pancreatic cancers as well as in metastatic lesions of the liver. These results demonstrate that neoplastic and normal endothelium in humans are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.
摘要翻译：为了更好地了解肿瘤血管生成，开发了分离内皮细胞（EC）和评估基因表达模式的新技术。当将来自正常和恶性结直肠组织的EC的转录物与来自非内皮细胞的转录物进行比较时，鉴定了主要在内皮中表达的170多种基因。正常和肿瘤来源的内皮细胞之间的比较显示79个差异表达的基因，包括46个在肿瘤相关内皮中特异性升高的基因。来自该组的代表性基因的实验证明，大多数在原发性肺癌，乳腺癌，脑癌和胰腺癌的内皮中以及在肝脏的转移性病变中类似地表达。这些结果表明，人类中的肿瘤和正常内皮在分子水平上是不同的，并且对于未来抗血管生成治疗的发展具有重要意义。

2. 发明授权

EP1572867B1 ENDOTHELIAL CELL EXPRESSION PATTERNS 有权
标题翻译：内皮细胞表达模式
公开(公告)号：EP1572867B1
公开(公告)日：2014-07-23
申请号：EP02728495.9
申请日：2002-04-10
申请人： The Johns Hopkins University
发明人： CARSON-WALTER, Eleanor , ST. CROIX, Brad , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
IPC分类号： C07K14/705 , G01N33/53 , C07K16/30
CPC分类号： C07K14/705 , A61K2039/505 , C07K14/4748 , C07K16/28 , G01N33/5023 , G01N33/68 , G01N2333/4703 , G01N2500/04 , G01N2800/7014 , G01N2800/7028
摘要： To gain a better understanding of tumor angiogenesis, new techniques for isolating endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed 79 differentially expressed genes, including 46 that were specifically elevated in tumor-associated endothelium. Experiments with representative genes from this group demonstrated that most were similarly expressed in the endothelium of primary lung, breast, brain, and pancreatic cancers as well as in metastatic lesions of the liver. These results demonstrate that neoplastic and normal endothelium in humans are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.

3. 发明公开

EP1307557A2 ENDOTHELIAL CELL EXPRESSION PATTERNS 审中-公开
标题翻译：表达者肛门内皮细胞
公开(公告)号：EP1307557A2
公开(公告)日：2003-05-07
申请号：EP01961827.1
申请日：2001-08-01
申请人： The Johns Hopkins University
发明人： ST. CROIX, Brad , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
IPC分类号： C12N15/12 , C07K16/28 , C07K19/00 , A61K39/395 , A61P35/00 , C07K14/705 , C12N5/10 , A61K39/00 , G01N33/50 , G01N33/574 , A61K38/17 , A61K51/10 , A61P9/00 , C12Q1/68 , A61K48/00
CPC分类号： C07K16/30 , A61K2039/505
摘要： To gain a better understanding of tumor angiogenesis, new techniques for isolating endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed 79 differentially expressed genes, including 46 that were specifically elevated in tumor-associated endothelium. Experiments with representative genes from this group demonstrated that most were similarly expressed in the endothelium of primary lung, breast, brain, and pancreatic cancers as well as in metastatic lesions of the liver. These results demonstrate that neoplastic and normal endothelium in humans are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.
摘要翻译：为了更好地了解肿瘤血管生成，开发了分离内皮细胞（ECs）和评估基因表达模式的新技术。将来自正常和恶性结肠直肠组织的ECs的转录物与来自非内皮细胞的转录物进行比较，鉴定出主要在内皮中表达的170多个基因。正常和肿瘤衍生的内皮的比较显示79个差异表达的基因，其中46个在肿瘤相关内皮特异性升高。来自该组的代表性基因的实验表明，大多数类似物在原发性肺癌，乳腺癌，脑癌和胰腺癌以及肝转移性损伤的内皮中均表达。这些结果表明，人类的肿瘤和正常内皮在分子水平上是不同的，并且对未来抗血管生成疗法的发展具有重要意义。

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