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1. 发明公开

EP3019531A1 IMMUNOGLOBULIN FUSION PROTEINS AND COMPOSITIONS THEREOF 审中-公开
标题翻译：免疫球蛋白融合蛋白及其组合物
公开(公告)号：EP3019531A1
公开(公告)日：2016-05-18
申请号：EP14822130.2
申请日：2014-07-11
申请人： The California Institute for Biomedical Research , The Scripps Research Institute
发明人： WANG, Feng , ZHANG, Yong , LIU, Tao , DU, Juanjuan , WANG, Ying , LIU, Yan , SCHULTZ, Peter, G.
IPC分类号： C07K16/46 , C12N15/09 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2863 , A61K39/395 , A61K47/65 , A61K47/6889 , A61K2039/505 , C07K14/43522 , C07K14/47 , C07K14/505 , C07K14/535 , C07K14/57563 , C07K14/5759 , C07K14/605 , C07K14/61 , C07K14/64 , C07K14/70503 , C07K14/811 , C07K16/1027 , C07K16/2866 , C07K16/32 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2318/10 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/55 , C07K2319/73
摘要： Disclosed herein are immunoglobulin fusion proteins that have a first antibody region attached to an extender fusion region. The extender fusion region contains a therapeutic agent and a beta strand secondary structure. The extender fusion region may contain 7 or fewer consecutive amino acids based on or derived from an ultralong CDR3. Alternatively, the extender fusion region contains a rigid stalk protein structure, but does not contain an amino acid sequence based on or derived from an ultralong CDR3. The extender fusion region may also have one or more linkers or proteolytic cleavage sites. The immunoglobulin fusion proteins may have additional therapeutic agents and extender fusion regions. Also disclosed herein are pharmaceutical compositions of immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject.

2. 发明公开

EP3019533A2 COILED COIL IMMUNOGLOBULIN FUSION PROTEINS AND COMPOSITIONS THEREOF 有权转让
标题翻译：杜鹃花D US US US US US US US US US US US US US US US US US US US
公开(公告)号：EP3019533A2
公开(公告)日：2016-05-18
申请号：EP14823623.5
申请日：2014-07-11
申请人： The California Institute for Biomedical Research
发明人： WANG, Feng , ZHANG, Yong , WANG, Ying , LIU, Yan , SCHULTZ, Peter, G.
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00
摘要： Disclosed herein are immunoglobulin fusion proteins that have a first antibody region attached to an extender fusion region. The extender fusion region contains a therapeutic agent and a beta strand secondary structure. The extender fusion region may contain 7 or fewer consecutive amino acids based on or derived from an ultralong CDR3. Alternatively, the extender fusion region contains a rigid stalk protein structure, but does not contain an amino acid sequence based on or derived from an ultralong CDR3. The extender fusion region may also have one or more linkers or proteolytic cleavage sites. The immunoglobulin fusion proteins may have additional therapeutic agents and extender fusion regions. Also disclosed herein are pharmaceutical compositions of immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject.
摘要翻译：本文公开了具有连接到增量融合区的第一抗体区的免疫球蛋白融合蛋白。增量融合区域含有治疗剂和β链二级结构。扩增融合区域可以含有7个或更少的基于或源自超长CDR3的连续氨基酸。或者，扩增体融合区域包含刚性茎蛋白质结构，但不包含基于或衍生自超长CDR3的氨基酸序列。扩展融合区也可以具有一个或多个接头或蛋白水解切割位点。免疫球蛋白融合蛋白可以具有另外的治疗剂和增量融合区域。本文还公开了免疫球蛋白融合蛋白的药物组合物和使用免疫球蛋白融合蛋白来治疗或预防受试者的疾病或病症的方法。

3. 发明公开

EP3152238A1 METHODS OF CONSTRUCTING AMINO TERMINAL IMMUNOGLOBULIN FUSION PROTEINS AND COMPOSITIONS THEREOF 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG AMINOTERMINALER IMMUNGLOBULINFUSIONSPROTEINE UND ZUSAMMENSETZUNGEN DAVON
公开(公告)号：EP3152238A1
公开(公告)日：2017-04-12
申请号：EP15803905.7
申请日：2015-06-05
申请人： The California Institute for Biomedical Research
发明人： WANG, Feng , LIU, Yan , WANG, Ying , FU, Guangsen , SCHULTZ, Peter, G.
IPC分类号： C07K19/00 , A61K39/395 , A61K47/50 , A61K38/26 , A61K38/28 , A61P37/00 , C12N15/63 , C12P21/08 , A61K38/22
CPC分类号： C07K16/2803 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/575 , C07K14/605 , C07K16/1027 , C07K16/18 , C07K16/2869 , C07K16/32 , C07K16/46 , C07K2317/24 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C07K2319/55 , C12P21/02
摘要： Disclosed herein are immunoglobulin fusion proteins comprising a first immunoglobulin region attached to a therapeutic peptide at the amino terminus of the immunoglobulin region. The immunoglobulin fusion proteins may further comprise a second immunoglobulin region. The immunoglobulin fusion protein may further comprise one or more connecting peptides, linkers, proteolytic cleavage sites, internal linkers, or a combination thereof. The immunoglobulin fusion proteins may further comprise one or more additional therapeutic peptides. Also disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject.
摘要翻译：本文公开了免疫球蛋白融合蛋白，其包含在免疫球蛋白区域的氨基末端附着于治疗肽的第一免疫球蛋白区域。免疫球蛋白融合蛋白可以进一步包含第二免疫球蛋白区域。免疫球蛋白融合蛋白还可以包含一个或多个连接肽，接头，蛋白水解切割位点，内部接头或其组合。免疫球蛋白融合蛋白可以进一步包含一种或多种另外的治疗肽。本文还公开了包含免疫球蛋白融合蛋白的组合物和使用免疫球蛋白融合蛋白来治疗或预防受试者的疾病或病症的方法。

4. 发明公开

EP3387019A2 RELAXIN IMMUNOGLOBULIN FUSION PROTEINS AND METHODS OF USE 有权转让
公开(公告)号：EP3387019A2
公开(公告)日：2018-10-17
申请号：EP16873899.5
申请日：2016-12-09
申请人： The California Institute for Biomedical Research
发明人： WANG, Feng , LIU, Yan , WANG, Ying , FU, Guangsen , SCHULTZ, Peter G.
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , C12N15/09
CPC分类号： C07K14/64 , C07K2319/00
摘要： Disclosed herein are relaxin immunoglobulin fusion proteins useful for the treatment or prevention of a disease or condition in a subject.

5. 发明公开

EP4011919A2 RELAXIN IMMUNOGLOBULIN FUSION PROTEINS AND METHODS OF USE 无效
公开(公告)号：EP4011919A2
公开(公告)日：2022-06-15
申请号：EP21203381.5
申请日：2016-12-09
申请人： The Scripps Research Institute
发明人： WANG, Feng , LIU, Yan , WANG, Ying , FU, Guangsen , SCHULTZ, Peter G.
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , C12N15/09 , C07K16/10 , C07K14/64 , A61P11/00 , A61P13/12
摘要： Disclosed herein are relaxin immunoglobulin fusion proteins useful for the treatment or prevention of a disease or condition in a subject.

6. 发明授权

EP3019533B1 COILED COIL IMMUNOGLOBULIN FUSION PROTEINS AND COMPOSITIONS THEREOF 有权转让
公开(公告)号：EP3019533B1
公开(公告)日：2020-01-08
申请号：EP14823623.5
申请日：2014-07-11
申请人： The Scripps Research Institute
发明人： WANG, Feng , ZHANG, Yong , WANG, Ying , LIU, Yan , SCHULTZ, Peter, G.
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , C12N15/62 , C07K16/10 , A61K47/65

7. 发明公开

EP4011919A3 RELAXIN IMMUNOGLOBULIN FUSION PROTEINS AND METHODS OF USE 无效
公开(公告)号：EP4011919A3
公开(公告)日：2022-10-12
申请号：EP21203381.5
申请日：2016-12-09
申请人： The Scripps Research Institute
发明人： WANG, Feng , LIU, Yan , WANG, Ying , FU, Guangsen , SCHULTZ, Peter G.
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , C12N15/09 , C07K16/10 , C07K14/64 , A61P11/00 , A61P13/12
摘要： Disclosed herein are relaxin immunoglobulin fusion proteins useful for the treatment or prevention of a disease or condition in a subject.

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