专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3247802A1 PROTEASE-ACTIVATED CONTRAST AGENTS FOR IN VIVO IMAGING 审中-实审转让
标题翻译：蛋白酶活化造影剂用于体内成像
公开(公告)号：EP3247802A1
公开(公告)日：2017-11-29
申请号：EP16740869.9
申请日：2016-01-22
申请人： The Board Of Trustees Of The Leland Stanford Junior University
发明人： BOGYO, Matthew S. , VERDOES, Martijn , OFORI, Leslie , WITHANA, Nimali P.
IPC分类号： C12Q1/37 , C07D401/14
CPC分类号： C07K5/06086 , A61K49/0032 , A61K49/0056 , A61K51/08 , A61K51/088 , C07D401/14 , C07D403/08 , C07D405/06
摘要： Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.

2. 发明公开

EP4310504A3 ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 审中-实审
公开(公告)号：EP4310504A3
公开(公告)日：2024-05-01
申请号：EP23207737.0
申请日：2017-12-23
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： BOGYIO, Matthew, S. , VERDOES, Martijn
IPC分类号： G01N21/63 , A61K49/00 , G01N33/68
CPC分类号： C12Q1/37 , G01N33/574 , G01N33/68 , G01N2333/94820130101 , A61K49/0032 , A61K49/0052
摘要： The present invention relates to a compound for use in labeling a protease having the formula (II):

wherein D comprises a benzoindole dye; L1 is a linker; AA1 is an amino acid side chain; U is O, NH, or S; R1 is alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, or a protecting group, and is optionally substituted with 1 to 3 A groups; each A is independently alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkylamino, aryl, aryloxy, arylamino, aralkyl, aralkoxy, aralkanoyl, aralkamino, heteroaryl, heteroaryloxy, heteroarylamino, heteroaralkyl, heteroaralkoxy, heteroaralkanoyl, heteroaralkamino, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkoxy, cycloalkanoyl, cycloalkamino, heterocyclyl, heterocyclyloxy, heterocyclylamino, heterocyclylalkyl, heterocyclylalkoxy, heterocyclylalkanoyl, heterocyclylalkamino, hydroxyl, thio, amino, alkanoylamino, aroylamino, aralkanoylamino, alkylcarboxy, carbonate, carbamate, guanidinyl, urea, halo, trihalomethyl, cyano, nitro, phosphoryl, sulfonyl, sulfonamido, or azido, L3 is a linker; and Q comprises a quencher, and wherein the benzoindole dye has the structure:

wherein o is an integer from 1 to 4; R2 is a C2-C8 alkyl group, optionally substituted with a sulfonate or carbonate; each R3 is independently a C1-C6 alkyl group; and L4 is an optionally substituted alkyl linker, wherein each carbon atom is optionally replaced with a heteroatom.

3. 发明公开

EP2971065A2 ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 有权转让
标题翻译：基于活动的探针化合物，组合物及其使用方法
公开(公告)号：EP2971065A2
公开(公告)日：2016-01-20
申请号：EP14764975.0
申请日：2014-03-15
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： BOGYO, Matthew, S. , VERDOES, Martijn
IPC分类号： C12Q1/37 , C07D401/00 , A61B5/00
CPC分类号： C07D401/14 , A61K49/0032 , A61K49/0034 , A61K49/0041
摘要： Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

4. 发明公开

EP4310504A2 ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 审中-实审
公开(公告)号：EP4310504A2
公开(公告)日：2024-01-24
申请号：EP23207737.0
申请日：2017-12-23
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： BOGYIO, Matthew, S. , VERDOES, Martijn
IPC分类号： G01N33/68
摘要： The present invention relates to a compound for use in labeling a protease having the formula (II):

wherein D comprises a benzoindole dye; L 1 is a linker; AA 1 is an amino acid side chain; U is O, NH, or S; R 1 is alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, or a protecting group, and is optionally substituted with 1 to 3 A groups; each A is independently alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkylamino, aryl, aryloxy, arylamino, aralkyl, aralkoxy, aralkanoyl, aralkamino, heteroaryl, heteroaryloxy, heteroarylamino, heteroaralkyl, heteroaralkoxy, heteroaralkanoyl, heteroaralkamino, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkoxy, cycloalkanoyl, cycloalkamino, heterocyclyl, heterocyclyloxy, heterocyclylamino, heterocyclylalkyl, heterocyclylalkoxy, heterocyclylalkanoyl, heterocyclylalkamino, hydroxyl, thio, amino, alkanoylamino, aroylamino, aralkanoylamino, alkylcarboxy, carbonate, carbamate, guanidinyl, urea, halo, trihalomethyl, cyano, nitro, phosphoryl, sulfonyl, sulfonamido, or azido, L 3 is a linker; and Q comprises a quencher, and wherein the benzoindole dye has the structure:

wherein o is an integer from 1 to 4; R 2 is a C 2 -C 8 alkyl group, optionally substituted with a sulfonate or carbonate; each R 3 is independently a C 1 -C 6 alkyl group; and L 4 is an optionally substituted alkyl linker, wherein each carbon atom is optionally replaced with a heteroatom.

5. 发明公开

EP4218829A3 ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 审中-实审
公开(公告)号：EP4218829A3
公开(公告)日：2023-08-16
申请号：EP22213062.7
申请日：2014-03-15
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： BOGYO, Matthew S. , VERDOES, Martijn
IPC分类号： A61K49/00 , C07D401/14
摘要： Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

6. 发明公开

EP4218829A2 ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 审中-实审
公开(公告)号：EP4218829A2
公开(公告)日：2023-08-02
申请号：EP22213062.7
申请日：2014-03-15
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： BOGYO, Matthew S. , VERDOES, Martijn
IPC分类号： A61K49/00 , C12Q1/37 , C07D401/14
摘要： Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

7. 发明公开

EP3601261A1 PROTEASE-ACTIVATED CONTRAST AGENTS FOR IN VIVO IMAGING 审中-实审
公开(公告)号：EP3601261A1
公开(公告)日：2020-02-05
申请号：EP18777788.3
申请日：2018-03-30
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： BOGYO, Matthew S. , VERDOES, Martijn , OFORI, Leslie , WITHANA, Nimali P.
IPC分类号： C07D401/14 , C12Q1/37

8. 发明公开

EP3510380A1 ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 有权转让
公开(公告)号：EP3510380A1
公开(公告)日：2019-07-17
申请号：EP17883805.8
申请日：2017-12-23
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： BOGYO, Matthew S. , VERDOES, Martijn
IPC分类号： G01N21/63 , A61K49/00 , G01N33/68

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式