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1. 发明公开

EP0381514A3 Use of N-methyl-sphingosine as inhibitor of cell growth 失效
标题翻译：作为细胞生长抑制剂的丝氨酸和N-甲基 - 丝胶蛋白
公开(公告)号：EP0381514A3
公开(公告)日：1991-07-17
申请号：EP90301099.9
申请日：1990-02-02
申请人： The Biomembrane Institute , CORNELL RESEARCH FOUNDATION, INC. , MECT CORPORATION
发明人： Igarashi, Yasuyuki , Toyokuni, Tatsushi , Hakomori, Sen-itiroh , Racker, Efraim, Department of Biochemistry , Fujita, Shuji , Sugimoto, Mamoru , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： A61K31/13
CPC分类号： A61K31/13
摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.

2. 发明授权

EP0381514B1 Use of N-methyl-sphingosine as inhibitor of cell growth 失效
标题翻译：使用N-甲基 - 鞘氨醇作为细胞生长抑制剂。
公开(公告)号：EP0381514B1
公开(公告)日：1995-05-17
申请号：EP90301099.9
申请日：1990-02-02
申请人： The Biomembrane Institute , CORNELL RESEARCH FOUNDATION, INC. , MECT CORPORATION
发明人： Igarashi, Yasuyuki , Toyokuni, Tatsushi , Hakomori, Sen-itiroh , Racker, Efraim, Department of Biochemistry , Fujita, Shuji , Sugimoto, Mamoru , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： A61K31/13
CPC分类号： A61K31/13

3. 发明公开

EP0381514A2 Use of N-methyl-sphingosine as inhibitor of cell growth 失效
标题翻译： Verwendung von Sphingosin und N-Methyl-Sphingosin als Zell-Wachstums-Inhibitor。
公开(公告)号：EP0381514A2
公开(公告)日：1990-08-08
申请号：EP90301099.9
申请日：1990-02-02
申请人： The Biomembrane Institute , CORNELL RESEARCH FOUNDATION, INC. , MECT CORPORATION
发明人： Igarashi, Yasuyuki , Toyokuni, Tatsushi , Hakomori, Sen-itiroh , Racker, Efraim, Department of Biochemistry , Fujita, Shuji , Sugimoto, Mamoru , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： A61K31/13
CPC分类号： A61K31/13
摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.
摘要翻译：一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。一种用于抑制体内人和动物细胞生长的方法，包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包括合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐。一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。一种在体内抑制人和动物细胞生长的方法，其包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或药学上可接受的盐它们。

4. 发明公开

EP0380084A3 Method for the inhibition of cell-cell and cell substratum interactions by the blocking of carbohydrate-carbohydrate interactions 失效
标题翻译：通过碳氢化合物 - 碳酸氢盐相互作用阻断细胞和细胞基质相互作用的方法
公开(公告)号：EP0380084A3
公开(公告)日：1991-03-13
申请号：EP90101430.8
申请日：1990-01-24
申请人： The Biomembrane Institute
发明人： Hakomori, Sen-itiroh , Eggens, Ivan , Fenderson, Bruce A. , Toyokuni, Tatsushi
IPC分类号： A61K31/70 , A61K39/395 , A61K37/02
CPC分类号： C07K16/30 , A01N43/16 , A01N61/00 , A61K8/60 , A61K8/64 , A61K8/645 , A61K8/73 , A61K31/70 , A61K38/00 , A61Q11/00
摘要： Methods for the inhibition of cell-cell and cell-substratum interactions by the blocking of carbohydrate-carbohydrate interactions are disclosed. Inhibition of cell-cell and cell-substratum interactions by the methods of the present invention permit the inhibition of a variety of biological phenomena, including metastases, mammalian diseases that are microbial in origin, mammalian fertilization, and plant pathologies. Suitable agents for blocking carbohydrate-carbohydrate interactions include saccharides, glycoconjugates, and antibodies directed against carbohydrate determinants.

5. 发明公开

EP0380084A2 Method for the inhibition of cell-cell and cell substratum interactions by the blocking of carbohydrate-carbohydrate interactions 失效
标题翻译：用于通过阻断碳水化合物 - 碳水化合物相互作用抑制细胞 - 细胞和细胞 - 底物相互作用的D法。
公开(公告)号：EP0380084A2
公开(公告)日：1990-08-01
申请号：EP90101430.8
申请日：1990-01-24
申请人： The Biomembrane Institute
发明人： Hakomori, Sen-itiroh , Eggens, Ivan , Fenderson, Bruce A. , Toyokuni, Tatsushi
IPC分类号： A61K31/70 , A61K39/395 , A61K37/02
CPC分类号： C07K16/30 , A01N43/16 , A01N61/00 , A61K8/60 , A61K8/64 , A61K8/645 , A61K8/73 , A61K31/70 , A61K38/00 , A61Q11/00
摘要： Methods for the inhibition of cell-cell and cell-substratum interactions by the blocking of carbohydrate-carbohydrate interactions are disclosed. Inhibition of cell-cell and cell-substratum interactions by the methods of the present invention permit the inhibition of a variety of biological phenomena, including metastases, mammalian diseases that are microbial in origin, mammalian fertilization, and plant pathologies. Suitable agents for blocking carbohydrate-carbohydrate interactions include saccharides, glycoconjugates, and antibodies directed against carbohydrate determinants.
摘要翻译：对于细胞 - 细胞和细胞 - 基质相互作用的由碳水化合物 - 碳水化合物相互作用的阻断抑制方法是游离缺失盘。通过本发明的方法中的细胞 - 细胞和细胞 - 基质相互作用的抑制允许各种生物学现象，包括癌转移的抑制，哺乳动物疾病确实是微生物来源的，哺乳动物受精和植物病理。用于阻挡碳水化合物 - 碳水化合物相互作用的合适的试剂包括糖类，糖缀合物，和针对碳水化合物决定簇的抗体。

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