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1. 发明公开

EP3334532A1 BEAD SEPARATION IN MICROFLUIDICS 有权
公开(公告)号：EP3334532A1
公开(公告)日：2018-06-20
申请号：EP16770817.1
申请日：2016-09-01
申请人： Tecan Trading AG
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
CPC分类号： C02F1/484 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502792 , B01L3/508 , B01L2200/025 , B01L2200/0668 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/043
摘要： A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

2. 发明授权

EP3344388B1 MAGNETIC CONDUITS IN MICROFLUIDICS 有权
公开(公告)号：EP3344388B1
公开(公告)日：2020-11-11
申请号：EP15766294.1
申请日：2015-09-02
申请人： Tecan Trading AG
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00

3. 发明公开

EP3169437A1 MICROFLUIDICS CARTRIDGE WITH PIPETTING GUIDE 审中-公开
标题翻译： MICROFLUIDIC墨盒与管道指南
公开(公告)号：EP3169437A1
公开(公告)日：2017-05-24
申请号：EP15821481.7
申请日：2015-07-15
申请人： Tecan Trading AG
发明人： LAY, Tiffany , HOFFMEYER, Daniel , KOPF-SILL, Anne R. , PERROUD, Thomas
IPC分类号： B01L3/02 , B81B1/00 , G01N27/447 , G01N27/453
CPC分类号： B01L3/502792 , B01L3/0275 , B01L3/50273 , B01L2200/027 , B01L2300/0816 , B01L2300/161 , B01L2400/0427
摘要： A disposable cartridge configured as a digital microfluidics system for manipulating samples in liquid portions having a cartridge accommodation site and a central control unit for controlling selection of individual electrodes of an electrode array located at the site and for providing plural electrodes with individual voltage pulses for manipulating liquid portions by electrowetting. The cartridge has a hydrophobic working surface and a rigid cover with a second hydrophobic surface, the hydrophobic surfaces facing each other and being separated in parallel planes by a gap. The cartridge has plural pipetting guides for safe entering/withdrawing liquids into/from the gap with a pipette tip. At least one of the pipetting guides provides an abutting surface sealingly admittable by a counter surface of a pipette tip, located at a pipetting orifice that reaches through the rigid cover, and configured to prevent a pipette tip from touching the hydrophobic working surface.
摘要翻译：一次性盒构造成数字微流体系统，用于操纵具有盒容纳部位的液体部分中的样本，以及中央控制单元，用于控制位于该部位处的电极阵列的单独电极的选择并且用于向多个电极提供用于操纵的单独电压脉冲液体部分通过电润湿。盒具有疏水工作表面和具有第二疏水表面的刚性盖，疏水表面彼此面对并且通过间隙在平行平面中分开。该盒具有多个移液引导件，用于使用移液管尖端安全地将液体输入/移出缝隙。至少一个移液引导件提供可被移液管尖端的反作用面密封地引入的抵靠表面，该抵接表面位于通过刚性盖到达的移液孔处并且被配置为防止移液管尖端接触疏水工作表面。

4. 发明公开

EP3804857A1 CARTRIDGE FOR ELECTROWETTING MICROFLUIDICS, SYSTEM AND METHOD 审中-实审
公开(公告)号：EP3804857A1
公开(公告)日：2021-04-14
申请号：EP20211461.7
申请日：2016-09-01
申请人： TECAN Trading AG
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
摘要： The invention concerns a cartridge (17), in particular a disposable cartridge, configured to control and manipulate liquids and to be positioned at a cartridge accommodation site (18) of a digital microfluidics system (1), the digital microfluidics system (1) comprising: (a) a number or array of individual electrodes (2) attached to a first substrate or PCB (3); (b) a central control unit (7) in operative contact with said individual electrodes (2) for controlling selection and for providing a number of said individual electrodes (2) that define a path of individual electrodes (2') with voltage for manipulating liquid portions (8-2) or liquid droplets (8-1) by electrowetting; and (c) a cartridge accommodation site (18) that is configured for taking up the cartridge (17); wherein the cartridge (17) comprises a flexible working film (19), a rigid cover plate (20), a first hydrophobic surface (5) that belongs to a flexible working film (19), a second hydrophobic surface (6) that belongs to a rigid cover plate (20) and a working gap (4) that is located in-between the two hydrophobic surfaces (5,6); the flexible working film (19) comprising a backside (21) that, when the cartridge (17) is accommodated on a cartridge accommodation site (18), provides an evacuation space (24) between the uppermost surface (22) of the cartridge accommodation site (18) and the backside (21) for establishing an underpressure produced in the evacuation space (24) produced by a vacuum source (23) of the digital microfluidics system (1), wherein the flexible working film (19) of the cartridge (17) comprises a semi-permeable constitution or a semi-permeable property.

5. 发明公开

EP3377223A1 COVER WITH MICRO-CONTAINER INTERFACE FOR COVERING A MICROFLUIDIC GAP 审中-实审
公开(公告)号：EP3377223A1
公开(公告)日：2018-09-26
申请号：EP16704826.3
申请日：2016-02-10
申请人： Tecan Trading AG
发明人： PERROUD, Thomas , HOFFMEYER, Daniel , KOPF-SILL, Anne R. , SAGER, Adrian
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502792 , B01L3/563 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B01L2300/047 , B01L2300/0645 , B01L2300/123 , B01L2400/0427 , B01L2400/0478
摘要： A cover (10) for use in a digital microfluidics system (16) for manipulating samples in liquid portions or droplets is provided. The digital microfluidics system (16) com- prises a first substrate (18) with an array of electrodes (24) and a central control unit (20) for controlling the selection and for providing a number of said electrodes with voltage for manipulating liquid portions or droplets by electrowetting. A working gap (30) with a gap height is located parallel to the array of electrodes (24) and in-between first and second hydrophobic surfaces (26,28) that face each other at least during operation of the digital microfluidics system (16). The cover (10) comprises on one side the second hydrophobic surface (28) and on another side at least one micro-container interface (32), which comprises at least one cone (34). The inner surface of the cone (34) is formed to provide a sealing form fit contact with an outer surface of an inserted micro-container nozzle (36), by which a liquid is transferrable through a fluidic access hole (38) formed into the cover (10) and interconnecting each cone (34) and the gap (30). The cover (10) may be part of a disposable cartridge (14) or may be provided separately.

6. 发明公开

EP3344388A1 MAGNETIC CONDUITS IN MICROFLUIDICS 有权
公开(公告)号：EP3344388A1
公开(公告)日：2018-07-11
申请号：EP15766294.1
申请日：2015-09-02
申请人： Tecan Trading AG
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
摘要： A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

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