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1. 发明授权

EP2838891B1 AROMATIC RING COMPOUND AS GHRELIN O-ACYLTRANSFERASE INHIBITOR 有权
标题翻译：芳香环化合物作为GHRELIN O-酰基转移酶抑制剂
公开(公告)号：EP2838891B1
公开(公告)日：2017-08-02
申请号：EP13710076.4
申请日：2013-02-22
申请人： Takeda Pharmaceutical Company Limited
发明人： TAKAKURA, Nobuyuki , BANNO, Yoshihiro , TERAO, Yoshito , OCHIDA, Atsuko , MORIMOTO, Sachie , KITAMURA, Shuji , TOMATA, Yoshihide , YASUMA, Tsuneo , IKOMA, Minoru , MASUDA, Kei
IPC分类号： C07D333/60 , C07D407/14 , C07D417/12 , C07D495/04 , C07D307/82 , A61K31/381 , A61K31/343 , A61K31/4355 , A61K31/4365 , A61P3/04
CPC分类号： C07D333/60 , C07D307/79 , C07D307/80 , C07D307/81 , C07D307/84 , C07D333/54 , C07D333/64 , C07D333/70 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D495/04

2. 发明公开

EP2440541A1 NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF 审中-公开
标题翻译：新简明环状化合物和使用
公开(公告)号：EP2440541A1
公开(公告)日：2012-04-18
申请号：EP10726333.7
申请日：2010-06-08
申请人： Takeda Pharmaceutical Company Limited
发明人： NEGORO, Nobuyuki , TERAO, Yoshito , MIKAMI, Satoshi , YUKAWA, Tomoya
IPC分类号： C07D307/82 , A61K31/343 , A61P3/10 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D307/80 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D471/04 , C07D491/04 , C07D491/10
CPC分类号： C07D307/82 , C07D307/80 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/04 , C07D491/10 , C07D498/04
摘要： A compound represented by the formula (I): wherein each symbol is as defined in the specification, and a salt thereof have a GPR40 receptor activation action and is useful as an insulin secretagogue or a prophylactic or therapeutic drug for diabetes and the like.

3. 发明公开

EP2271646A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS 审中-公开
标题翻译：控制激酶1凋亡信号的抑制剂
公开(公告)号：EP2271646A1
公开(公告)日：2011-01-12
申请号：EP09728425.1
申请日：2009-03-30
申请人： Takeda Pharmaceutical Company Limited
发明人： CHANG, Edcon , DUONG, Tracy , HIRANO, Takehiro , MCNEILL, Matthew, H. , TERAO, Yoshito , VASSAR, Angie
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28 , A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519
摘要： The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I); wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

4. 发明公开

EP2058309A1 FUSED HETEROCYCLIC COMPOUND 审中-公开
标题翻译：熔合杂环化合物
公开(公告)号：EP2058309A1
公开(公告)日：2009-05-13
申请号：EP07791901.7
申请日：2007-08-03
申请人： Takeda Pharmaceutical Company Limited
发明人： UCHIKAWA, Osamu , SAKAI, Nozomu , TERAO, Yoshito , SUZUKI, Hideo
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P3/02 , A61P3/10 , A61P5/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P17/00 , A61P19/00 , A61P19/10 , A61P25/00 , A61P25/28 , A61P25/30 , A61P29/00
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D491/14
摘要： The present invention provides a compound represented by the formula (I):

wherein
ring A is a ring which is optionally further substituted;
R 1 is a hydrogen atom or a substituent;
R 2 is a hydrogen atom or a substituent;
R 3 is a hydrogen atom or a substituent;
R 4 is a hydrogen atom or a substituent;
R 5 is a hydrogen atom or a substituent;
R 6 is a hydrogen atom or a substituent;
X is =N- or =C(Z)- (Z is a hydrogen atom or a substituent);
when X is =C(Z)-, Z and R 6 are optionally bonded to each other to form, together with the carbon atom bonded thereto, an optionally substituted ring,
provided that when X is =CH-, then R 6 is not optionally substituted 2-piperidinyl, excluding N-imidazo[1,2-a]pyridin-2-yl-4-methyl-benzamide, N-imidazo[1,2-a]pyridin-2-yl-benzamide and N-(7-methylimidazo[1,2-a]pyridin-2-yl)-benzamide, or a salt thereof, and a pharmaceutical agent containing same. The compound of the present invention has an ASK1 inhibitory action, and is useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, inflammatory diseases and the like, and the like.
摘要翻译：本发明提供由式（I）表示的化合物：其中环A是任选进一步被取代的环; R1是氢原子或取代基; R2是氢原子或取代基; R3是氢原子或取代基; R4是氢原子或取代基; R5是氢原子或取代基; R6是氢原子或取代基; X是= N-或= C（Z） - （Z是氢原子或取代基）; 当X是= C（Z） - 时，Z和R6任选彼此键合以与其键合的碳原子一起形成任选取代的环，条件是当X是= CH-时，则R6不是任选取代的不包括N-咪唑并[1,2-a]吡啶-2-基-4-甲基 - 苯甲酰胺，N-咪唑并[1,2-a]吡啶-2-基 - 苯甲酰胺和N-（7- -2-甲基咪唑并[1,2-a]吡啶-2-基） - 苯甲酰胺或其盐以及含有它们的药剂。本发明的化合物具有ASK1抑制作用，可用作预防或治疗糖尿病，炎症性疾病等的药剂等药剂。

5. 发明授权

EP2522657B1 INDOLE DERIVATIVE 有权
标题翻译：吲哚衍生物
公开(公告)号：EP2522657B1
公开(公告)日：2016-08-03
申请号：EP11731802.2
申请日：2011-01-05
申请人： Takeda Pharmaceutical Company Limited
发明人： MASADA, Shinichi , TERAO, Yoshito , MURATA, Toshiki
IPC分类号： C07D209/14 , A61K31/404 , A61K31/454 , A61P3/04 , A61P43/00 , C07D401/06 , C07D405/12 , C07D405/14 , C07D409/12
CPC分类号： C07D209/14 , C07D401/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14

6. 发明公开

EP2838891A1 AROMATIC RING COMPOUND 有权
标题翻译： AROMATISCHE RINGVERBINDUNG ALS GHRELIN O-ACYLTRANSFERASE HEMMER
公开(公告)号：EP2838891A1
公开(公告)日：2015-02-25
申请号：EP13710076.4
申请日：2013-02-22
申请人： Takeda Pharmaceutical Company Limited
发明人： TAKAKURA, Nobuyuki , BANNO, Yoshihiro , TERAO, Yoshito , OCHIDA, Atsuko , MORIMOTO, Sachie , KITAMURA, Shuji , TOMATA, Yoshihide , YASUMA, Tsuneo , IKOMA, Minoru , MASUDA, Kei
IPC分类号： C07D333/60 , C07D407/14 , C07D417/12 , C07D495/04 , C07D307/82 , A61K31/381 , A61K31/343 , A61K31/4355 , A61K31/4365 , A61P3/04
CPC分类号： C07D333/60 , C07D307/79 , C07D307/80 , C07D307/81 , C07D307/84 , C07D333/54 , C07D333/64 , C07D333/70 , C07D405/04 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/12 , C07D495/04
摘要： The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供具有GOAT抑制作用的化合物，其可用于预防或治疗肥胖症等，并且具有优异的功效。本发明是由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。

7. 发明公开

EP2522657A1 INDOLE DERIVATIVE 有权
标题翻译：吲哚衍生物
公开(公告)号：EP2522657A1
公开(公告)日：2012-11-14
申请号：EP11731802.2
申请日：2011-01-05
申请人： Takeda Pharmaceutical Company Limited
发明人： MASADA, Shinichi , TERAO, Yoshito , MURATA, Toshiki
IPC分类号： C07D209/14 , A61K31/404 , A61K31/454 , A61P3/04 , A61P43/00 , C07D401/06 , C07D405/12 , C07D405/14 , C07D409/12
CPC分类号： C07D209/14 , C07D401/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The present invention provides an indole derivative having a melanin-concentrating hormone receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of obesity and the like.
The present invention relates to a compound represented by the formula (I):

wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供具有黑素浓缩激素受体拮抗作用的吲哚衍生物，其可用作预防或治疗肥胖症等的药剂。本发明涉及由式（I）表示的化合物或其盐，其中每个符号如说明书中所定义。

8. 发明公开

EP3896060A1 HETEROCYCLIC COMPOUND 有权
公开(公告)号：EP3896060A1
公开(公告)日：2021-10-20
申请号：EP19895161.8
申请日：2019-12-11
申请人： Takeda Pharmaceutical Company Limited
发明人： KAJITA, Yuichi , MIYANOHANA, Yuhei , KOIKE, Tatsuki , HOASHI, Yasutaka , HATTORI, Yasushi , TOKUNAGA, Norihito , ODA, Tsuneo , MIYAZAKI, Tohru , UYGHUR, Dilhumar , ITO, Yoshiteru , TAKEUCHI, Kohei , IMAMURA, Keisuke , SUGIMOTO, Takahiro , FUKUDA, Koichiro , KOHARA, Yasuhisa , OKAMOTO, Rei , OHRA, Taiichi , MIYAMOTO, Naoki , TERAO, Yoshito , KAWASAKI, Masanori
IPC分类号： C07D215/38 , A61K31/416 , A61K31/428 , A61K31/437 , A61K31/47 , A61K31/506 , A61P25/20 , A61P43/00 , C07D231/54 , C07D401/14 , C07D471/04
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):

wherein each symbol is as described in the description,
or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

9. 发明公开

EP3895707A1 HETEROCYCLIC COMPOUND 有权
公开(公告)号：EP3895707A1
公开(公告)日：2021-10-20
申请号：EP19895831.6
申请日：2019-12-11
申请人： Takeda Pharmaceutical Company Limited
发明人： MIYANOHANA, Yuhei , KAJITA, Yuichi , KOIKE, Tatsuki , HOASHI, Yasutaka , HATTORI, Yasushi , TOKUNAGA, Norihito , ODA, Tsuneo , MIYAZAKI, Tohru , UYGHUR, Dilhumar , ITO, Yoshiteru , TAKEUCHI, Kohei , IMAMURA, Keisuke , SUGIMOTO, Takahiro , FUKUDA, Koichiro , KOHARA, Yasuhisa , OKAMOTO, Rei , OHRA, Taiichi , MIYAMOTO, Naoki , CHIBA, Jun , TERAO, Yoshito , KAWASAKI, Masanori
IPC分类号： A61K31/437
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):

wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

10. 发明公开

EP3601256A1 IP6K INHIBITORS 审中-公开
公开(公告)号：EP3601256A1
公开(公告)日：2020-02-05
申请号：EP18723386.1
申请日：2018-03-29
申请人： Takeda Pharmaceutical Company Limited
发明人： TERAO, Yoshito , TAKAHASHI, Masashi , HARA, Ryoma , HIDAKA, Kousuke , FURUKAWA, Hideki , YAMASAKI, Takeshi , KASAI, Shizuo
IPC分类号： C07D401/12 , C07D209/54 , A61K31/404 , A61P9/00

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