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1. 发明公开

EP1572113A2 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 有权转让
标题翻译： CALRIUM-REZEPTOR-MODULIERENDE VERBINDUNG UND IHRE VERWENDUNG
公开(公告)号：EP1572113A2
公开(公告)日：2005-09-14
申请号：EP03793273.8
申请日：2003-08-21
申请人： Takeda Pharmaceutical Company Limited
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： A61K6/00
CPC分类号： C07D487/04
摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7- membered ring; ring B is an optionally substituted 5- to 7- membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and --- is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7- membered ring; Q is C, CR5 or N; R8, R9,R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.
摘要翻译：提供了包含式（I）化合物的钙受体调节剂：其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X1是CR1，CR1R2，N或NR13; X2为N或NR3; Y为C，CR4或N，Z为CR5，CR5R6，N或NR7; Ar是任选取代的环状基团; R为H，任选取代的烃基等; ＆lt; img id =“CUSTOM-CHARACTER-00001”he =“3.13mm”wi =“8.47mm”file =“US20090215746A1-20090827-P00001.TIF”img-content =“character”img-format =“tif”/ >是单键或双键; R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 13独立地为H，任选取代的烃基; 或其盐或其前药。式（II）和（III）的化合物：其中环A是任选取代的5-至7-元环; Q为C，CR5或N; R8，R9，R10，R11和R12独立地为H，任意取代的烃基等，或其盐。也如前所述，在式（II）和（III）中指定X1，R3，R1，Y和X3。

2. 发明公开

EP1541564A1 FIVE-MEMBERED HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译： F NFGLIEDRIGE HETEROCYCLISCHE VERBINDUNGEN
公开(公告)号：EP1541564A1
公开(公告)日：2005-06-15
申请号：EP03795338.7
申请日：2003-09-09
申请人： Takeda Pharmaceutical Company Limited
发明人： MOMOSE, Yu , TAKAKURA, Nobuyuki , MAEKAWA, Tsuyoshi , ODAKA, Hiroyuki , KIMURA, Hiroyuki
IPC分类号： C07D263/32 , C07D413/12 , C07D413/14 , C07D417/14 , C07D417/12 , C07D401/14 , C07D403/12 , C07F7/18 , C07F9/6558 , A61K31/422 , A61K31/4439 , A61K31/427 , A61K31/4245 , A61K31/454 , A61K31/5377 , A61K31/675 , A61K31/695 , A61K31/662 , A61P3/06 , A61P3/04 , A61P3/10
CPC分类号： C07D263/32 , C07F9/6558 , C07F9/65583
摘要： The present invention provides a compound represented by the formula:
wherein R 1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is -(CH 2 ) n -Z 1 - or -Z 1 -(CH 2 ) n - (n is an integer of 0 to 8, Z 1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R 2 is a hydrogen atom, a cyano group, -PO(OR 9 )(OR 10 ) (R 9 and R 10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R 9 and R 10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.
摘要翻译：本发明提供由下式表示的化合物：其中R 1为任选取代的5元杂环基; X，Y和V相同或不同，各自为键，氧原子，硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n Z 1 - 或-Z 1 - （CH 2）n - （n是0至8的整数，Z 1是键，氧原子，硫原子和喜欢）; 环B是任选还含有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子，氰基，-PO（OR 9）（OR 10）（R 9和R 10）相同或不同，各自为氢原子或任选取代的烃基，R 9和R 10任选地键合以形成任选取代的环）等，或其盐具有优异的脂肪组织重量减轻作用，降血糖作用和降血脂症作为预防或治疗肥胖症，糖尿病，高脂血症，葡萄糖耐量降低，高血压等的作用剂。

3. 发明授权

EP1572113B1 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 有权转让
标题翻译：钙受体调节化合物及其用途
公开(公告)号：EP1572113B1
公开(公告)日：2017-05-17
申请号：EP03793273.8
申请日：2003-08-21
申请人： Takeda Pharmaceutical Company Limited
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： C07D487/04 , C07D221/04 , C07D471/04 , A61K31/519 , A61K31/473 , A61K31/551 , A61K31/53 , A61P19/10
CPC分类号： C07D487/04

4. 发明授权

EP1357115B1 ALKANOIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE THEREOF 有权
标题翻译：的烷酸衍生物，用于生产及其用途
公开(公告)号：EP1357115B1
公开(公告)日：2009-06-17
申请号：EP01272544.6
申请日：2001-12-28
申请人： Takeda Pharmaceutical Company Limited
发明人： MOMOSE, Yu , MAEKAWA, Tsuyoshi , TAKAKURA, Nobuyuki , ODAKA, Hiroyuki , KIMURA, Hiroyuki , ITO, Tatsuya
IPC分类号： C07D263/32
CPC分类号： C07D403/04 , C07D263/32 , C07D277/24 , C07D277/42 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： Alkanoic acid derivatives represented by the general formula (I) or salts thereof, useful as preventive and/or therapeutic agents for diabetes, hyperlipidemia, impaired glucose tolerance, and so on: (I) wherein R1 is an optionally substituted five-membered aromatic heterocyclic group; X is a free valency or the like; Q is a divalent hydrocarbon group containing 1 to 20 carbon atoms; Y is a free valency or the like; A is an aromatic ring which may have one to three substituents; Z is -(CH¿2)n-Z?1- (wherein n is an integer of 1 to 8; and Z1 is oxygen or the like) or the like; B is an optionally mono- to tri-substituted pyridine ring or the like; U is a free valency or the like; W is a divalent hydrocarbon group containing 1 to 20 carbon atoms; and R3 is -OH or the like, with the proviso that when B is an optionally mono- to tri-substituted benzene ring, U is a free valency.

5. 发明公开

EP1513817A1 1, 2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY 审中-公开
标题翻译：的降血糖1,2-吡咯衍生物具有与效果HYPOLIPIDEMISCHER
公开(公告)号：EP1513817A1
公开(公告)日：2005-03-16
申请号：EP03730575.2
申请日：2003-05-22
申请人： Takeda Pharmaceutical Company Limited
发明人： MAEKAWA, Tsuyoshi , HARA, Ryoma , ODAKA, Hiroyuki , KIMURA, Hiroyuki , MIZUFUNE, Hideya , FUKATSU, Kohji
IPC分类号： C07D231/12 , C07D261/08 , C07D401/04 , C07D413/12 , A61K31/4155 , A61K31/415 , A61K31/42 , A61K31/422 , A61K31/4439 , C07D231/14 , C07D231/20 , C07D231/22 , C07D401/14 , C07D403/04 , C07D403/14
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D261/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/12 , C07D417/04
摘要： A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.

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