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    • 1. 发明公开
    • Cross-flow ultrafiltration device and method for concentration of pharmaceutical compositions
    • 超级冯pharmazeutischen Zusammensetzungen
    • EP2727643A1
    • 2014-05-07
    • EP12190793.5
    • 2012-10-31
    • Takeda GmbH
    • Rast, Markus
    • B01D61/14B01D63/08
    • B01D61/145B01D63/087B01D2313/10B01D2313/20
    • The present invention relates to increasing concentration of a therapeutically active biomolecule in a pharmaceutical composition for immediate administration to the patient. In particular, the present invention provides a filtering adapter (100), a filtration device (101), and a method of concentrating a therapeutically active biomolecule in a solution. In specific embodiments, syringes (102,103) are fluid-tightly attached to a filtering adapter, which provides for a filtration functionality by means of e. g. an ultrafiltration membrane. The filtration process may be carried out until the pharmaceutical composition is provided in a volume and concentration which is ready for administration. Furthermore, a further syringe may be attached to the filtering adapter to remove the desired volume with the desired concentration from the filtering adapter, such that the immediate administration can be carried out.
    • 本发明涉及药物组合物中治疗活性生物分子浓度的增加,用于立即给予患者。 特别地,本发明提供一种过滤适配器(100),过滤装置(101)以及将治疗活性生物分子浓缩在溶液中的方法。 在具体实施方案中,注射器(102,103)流体密封地连接到过滤适配器,其通过以下方式提供过滤功能。 G。 超滤膜。 可以进行过滤过程,直到药物组合物以准备投入的体积和浓度来提供。 此外,另外的注射器可以附接到过滤适配器以从过滤适配器去除具有所需浓度的所需体积,使得可以进行立即给药。