专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0395217A2 Bio-organic synthesis of dimeric LeX (difucosyl Y2; III3FucV3-FuncnLc6Cer) and analogues thereof 失效
标题翻译： Bio-organische Synthese von dimerem LeX（difucosyl y2; III3FucV3FucnLc6Cer）和Analogen hiervon。
公开(公告)号：EP0395217A2
公开(公告)日：1990-10-31
申请号：EP90303034.4
申请日：1990-03-21
申请人： THE BIOMEMBRANE INSTITUTE
发明人： Nudelman, Edward , Sadozai, Khalid , Clausen, Henrik , Hakomori, Sen-itiroh , Stroud, Mark, R.
IPC分类号： C12P19/04
CPC分类号： C12P19/04
摘要： A process for preparing difucosyl Y₂ antigen (dimeric Le x ), said process comprising: (1) preparing a lacto nor hexaosylceramide backbone or a lacto nor hexaosylsaccharide backbone linked to a carrier molecule; and (2) enzymatically fucosylating said backbone at the III³ and V³ positions through an α1->3 linkage. A process for preparing Le y antigen analogues, said process comprising: (1) preparing a lacto nor hexaosylceramide backbone or a lacto nor hexaosylsaccharide backbone linked to a carrier molecule; (2) enzymatically fucosylating said backbone at the terminal β-Gal through an α1->2 linkage; and (3) enzymatically fucosylating said backbone at one or more positions through an α1->3 linkage, provided that steps (2) and (3) can be conducted simultaneously or in any order. A process for preparing a fucosylated lacto nor hexaosylceramide, lacto nor hexaosylsaccharide linked to a carrier molecule or higher analogues thereof, said process comprising: (1) preparing a lacto nor hexaosylceramide backbone, a lacto nor hexaosylsaccharide backbone linked to a carrier molecule or backbones of higher analogues thereof; and (2) enzymatically fucosylating one or more residues of said backbone.
摘要翻译：一种制备二氟蔗糖Y2抗原（二聚体Le x）的方法，所述方法包括：（1）制备与载体分子连接的乳酰六烯酰基神经酰胺主链或乳糖六糖糖主链; 和（2）通过α1-> 3键在III 3和V 3位置对所述骨架进行酶促岩藻糖化。一种制备Le y抗原类似物的方法，所述方法包括：（1）制备与载体分子连接的乳酰六烯酰基神经酰胺主链或乳糖六糖糖主链; （2）通过α1-> 2键在末端β-Gal处对所述骨架进行酶促岩藻糖化; 和（3）通过α1-> 3键在一个或多个位置对所述骨架进行酶促岩藻糖化，条件是步骤（2）和（3）可以同时或以任何顺序进行。一种制备岩藻糖基化的乳酰六烯酰基神经酰胺，与载体分子或其更高类似物连接的内酯六糖基糖的方法，所述方法包括：（1）制备乳糖六烯酰基神经酰胺主链，连接于载体分子或其较高类似物的骨架的乳糖六糖糖主链; 和（2）将所述骨架的一个或多个残基酶解岩藻糖化。

IPRDB

热门服务

关于我们

友情链接

联系方式