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1. 发明公开

EP2038262A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译： Hsp90的活性来调节三唑
公开(公告)号：EP2038262A2
公开(公告)日：2009-03-25
申请号：EP07795380.0
申请日：2007-05-25
申请人： Synta Pharmaceuticals Corporation
发明人： CHIMMANAMADA, Dinesh, U. , YING, Weiwen , PRZEWLOKA, Teresa , ZHANG, Shijie , FOLEY, Kevin , DU, Zhenjian , ZHOU, Dan , QIN, Shuzhen
IPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , A61K31/4196 , A61P31/00
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/65186
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

2. 发明公开

EP2035396A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：三唑化合物调节HSP90活性
公开(公告)号：EP2035396A2
公开(公告)日：2009-03-18
申请号：EP07795379.2
申请日：2007-05-25
申请人： Synta Pharmaceuticals Corporation
发明人： YING, Weiwen , PRZEWLOKA, Teresa , CHAE, Junghyun , ZHANG, Shijie , LI, Hao , DU, Zhenjian , JAMES, David , CHIMMANAMADA, Dinesh, U. , NG, Howard, P. , FOLEY, Kevin , DEMKO, Zachary , SUN, Lijun , ZHOU, Dan , QIN, Shuzhen
IPC分类号： C07D249/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04 , A61K31/4196 , A61P35/00
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明进一步涉及在有需要的受试者中抑制Hsp90的活性的方法以及用于在需要其的受试者中预防或治疗过度增殖性病症例如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

3. 发明公开

EP1919882A2 ISOXAZOLE COMBRETASTATIN DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：异恶唑考布他汀衍生物对治疗增生性疾病
公开(公告)号：EP1919882A2
公开(公告)日：2008-05-14
申请号：EP06735424.1
申请日：2006-02-16
申请人： Synta Pharmaceuticals Corporation
发明人： SUN, Lijun , BORELLA, Christopher , LI, Hao , JIANG, Jun , CHEN, Shoujun , KOYA, Keizo , INOUE, Takayo , DU, Zhenjian , FOLEY, Kevin , WU, Yaming , ZHANG, Mei , YING, Weiwen
IPC分类号： C07D261/08 , C07D413/04 , A61K31/42 , A61P35/00
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.

4. 发明公开

EP2034996A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 审中-公开
标题翻译： HSP90活性来调节三唑
公开(公告)号：EP2034996A2
公开(公告)日：2009-03-18
申请号：EP07809199.8
申请日：2007-05-25
申请人： Synta Pharmaceuticals Corporation
发明人： CHAE, Junghyun , DEMKO, Zachary , YING, Weiwen , DU, Zhenjian , FOLEY, Kevin , JAMES, David , PRZEWLOKA, Teresa , SONG, Minghu , ZHANG, Shijie , NG, Howard, P. , LI, Hao , CHIMMANAMADA, Dinesh, U. , ZHOU, Dan , QIN, Shuzhen , LEE, Chi-wan , SUN, Lijun , KOYA, Keizo
IPC分类号： A61K31/4196 , A61P31/00 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04 , C07D417/04
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

5. 发明公开

EP1817295A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权转让
标题翻译： HSP90活性来调节三唑
公开(公告)号：EP1817295A1
公开(公告)日：2007-08-15
申请号：EP05851788.9
申请日：2005-11-17
申请人： Synta Pharmaceuticals Corporation
发明人： YING, Weiwen , JAMES, David , ZHANG, Shijie , PRZEWLOKA, Teresa , CHAE, Junghyun , CHIMMANAMADA, Dinesh, U. , LEE, Chi-Wan , KOSTIK, Elena , NG, Howard, P. , FOLEY, Kevin , DU, Zhenjian , BARSOUM, James
IPC分类号： C07D249/12 , C07D401/04 , C07D405/04 , C07D403/04 , A61K31/4196 , A61P35/00
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

6. 发明公开

EP1732900A2 ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
标题翻译： FOR炎性和免疫特定用途的丙烯腈衍生物
公开(公告)号：EP1732900A2
公开(公告)日：2006-12-20
申请号：EP05744197.4
申请日：2005-03-24
申请人： Synta Pharmaceuticals Corporation
发明人： CHEN, Shoujun , YING, Weiwen , JIANG, Jun , ONO, Mitsunori , SUN, Lijun
IPC分类号： C07D231/14 , A61K31/415
CPC分类号： C07D231/12 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
摘要： What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein.

7. 发明授权

EP1432709B8 1-GLYOXYLAMIDE INDOLIZINES FOR TREATING CANCER 有权
标题翻译： 1-glyoxlylamideindolizines用于癌症的治疗
公开(公告)号：EP1432709B8
公开(公告)日：2005-11-02
申请号：EP02798231.3
申请日：2002-09-13
申请人： Synta Pharmaceuticals Corporation
发明人： KOYA, Keizo , SUN, Lijun , ONO, Mitsunori , YING, Weiwen , LI, Hao
IPC分类号： C07D471/04 , A61P35/00
CPC分类号： C07D471/04

8. 发明公开

EP1556140A2 NOVEL COMPOUNDS 审中-公开
标题翻译：新化合物
公开(公告)号：EP1556140A2
公开(公告)日：2005-07-27
申请号：EP03776373.7
申请日：2003-10-14
申请人： Synta Pharmaceuticals Corporation
发明人： SUN, Lijun , ONO, Mitsunori , WADA, Yumiko , YING, Weiwen , PRZEWLOKA, Teresa , KOSTIK, Elena
IPC分类号： A61P19/02 , A61P17/06 , A61P3/10 , A61P1/00 , C07D487/04 , C07D471/04 , C07D498/04 , C07D513/04 , C07D401/10 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K31/52 , A61K31/522 , A61K31/541 , A61K31/5355 , A61K31/4745 , A61K31/4743 , A61K31/496
CPC分类号： C07D473/34 , C07D473/16 , C07D473/18
摘要： This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R3 is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, ORa, OC(O)Ra, OC(O)NRaRb, NRaRb, NRaC(O)Rb, NRaS(O)Rb, NRaS(O)2Rb, NRaC(O)NRbRc NRaC(S)NRbR°, NRaC(NRb)NRcRd, NRaC(O)ORb, S(O)NTRaRt, S(O)2NRSRb, S(O)Ra, S(O)2Ra, C(O)Ra, C(O)ORa, or C(O)NRaRl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is 0, S, S(O), S(O)2, or NW; B is N or CRC; X is 0, S, S(O), S(O)2, NR, or C(O); Y is a covalent bond, C(O), C=NR a, O, S, S(O), S(O)2, or NW; Z is N or CH; each of U and V, independently, is N or CR; and W is 0, S, or NR'; in which each of Ra, Rb, Re, and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Re is H, alkyl, aryl, acyl, or sufonyl; and Rf is H, alkyl., aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin- 12 overproduction-related disorder.
摘要翻译：本发明的特征在于式（I）的化合物：R 1是芳基或杂芳基; R 2和R 4中的每一个独立地为H，卤素，CN，烷基，ORa或NRaRb; （O）R a，OC（O）NR a R b，NR a R b，NR a C（O）R b，NR a S（O）R b，其中R b是H，卤素，CN，烷基，烯基，炔基，芳基，杂芳基，（O）2Rb，NRaC（O）NRbRc，NRaC（S）NRbR°，NRaC（NRb）NRcRd，NRaC（O）ORb，S（O）NTRaRt，S（O）2NRSRb，S（O）Ra，S O）2Ra，C（O）R a，C（O）ORa或C（O）NR a R 1; R5是H或烷基; n是0,1,2,3,4,5或6; A是O，S，S（O），S（O）2或NW; B是N或CRC; X是O，S，S（O），S（O）2，NR或C（O）; Y是共价键，C（O），C = NR a，O，S，S（O），S（O）2或NW; Z是N或CH; U和V中的每一个独立地是N或CR; 和W是0，S或NR'; 其中Ra，Rb，Re和Rd中的每一个独立地为H，烷基，芳基，杂芳基，环基或杂环基; Re是H，烷基，芳基，酰基或磺酰基; Rf为H，烷基，芳基，酰基，磺酰基，烷氧基，氨基，酯，酰胺，CN或卤素。该化合物可用于治疗白介素-12过量产生相关疾病。

9. 发明公开

EP2118077A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权转让
标题翻译：三唑化合物调节HSP90活性
公开(公告)号：EP2118077A2
公开(公告)日：2009-11-18
申请号：EP08725339.9
申请日：2008-02-08
申请人： Synta Pharmaceuticals Corporation
发明人： CHIMMANAMADA, Dinesh, U. , BURLISON, Joseph, A. , YING, Weiwen , SUN, Lijun , SCHWEIZER, Stefan, Michael , ZHANG, Shijie , DEMKO, Zachary , JAMES, David , PRZEWLOKA, Teresa
IPC分类号： C07D249/08
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperprolif erative disorders, such as cancer, in a subject in need thereof.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明进一步涉及本发明的取代三唑化合物或包含该化合物的组合物在制备用于预防或治疗有需要的受试者的过度增殖性疾病如癌症的药物中的用途。

10. 发明公开

EP1951679A1 IMIDAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：其调节Hsp90活性的咪唑化合物
公开(公告)号：EP1951679A1
公开(公告)日：2008-08-06
申请号：EP06801197.2
申请日：2006-08-10
申请人： Synta Pharmaceuticals Corporation
发明人： YING, Weiwen , DU, Zhenjian , FOLEY, Kevin
IPC分类号： C07D233/70 , C07D403/04 , C07D233/84 , C07D233/88 , A61K31/4168 , A61P35/00
CPC分类号： A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/428 , A61K31/4709 , A61K31/52 , A61K31/5377 , A61K31/675 , C07D233/70 , C07D233/84 , C07D233/88 , C07D403/02 , C07D403/04 , C07D403/10 , C07F9/65065
摘要： Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Formula (I) Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14- membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.

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