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1. 发明授权

EP1708765B1 BIOCOMPATIBLE POLYMERIZATION ACCELERATORS 有权
标题翻译： BIOKOMPATIBLE POLYMERISATIONSBESCHLEUNIGER
公开(公告)号：EP1708765B1
公开(公告)日：2016-08-31
申请号：EP04810988.8
申请日：2004-11-15
申请人： SurModics, Inc.
发明人： SWAN, Dale, G. , CHUDZIK, Stephen, J. , OFSTEAD, Ronald, F.
IPC分类号： A61L27/38 , A61L27/34 , A61L29/08 , C08F4/00
CPC分类号： A61L27/38 , A61L27/34 , A61L29/085 , A61L31/10 , C08F4/00 , Y10S530/812 , Y10S530/817

2. 发明公开

EP2015794A2 HYDROPHILIC SHAPE MEMORY INSERTABLE MEDICAL ARTICLES 审中-公开
标题翻译：亲水使用具有形状记忆医疗用品
公开(公告)号：EP2015794A2
公开(公告)日：2009-01-21
申请号：EP07776280.5
申请日：2007-04-25
申请人： SurModics, Inc.
发明人： CHUDZIK, Stephen, J. , JELLE, Bruce, M.
IPC分类号： A61L31/04 , A61L31/14
CPC分类号： A61L31/14 , A61L31/04 , A61L2400/16
摘要： Insertable medical articles with a shape memory property having a body member formed of crosslinked hydrophilic polymers are described.

3. 发明公开

EP1926505A1 IN VIVO FORMED MATRICES INCLUDING NATURAL BIODEGRADABLE POLYSACCHARIDES AND OPHTHALMIC USES THEREOF 有权
标题翻译：体内模具形状和天然生物可降解多糖及其用途眼科
公开(公告)号：EP1926505A1
公开(公告)日：2008-06-04
申请号：EP06815019.2
申请日：2006-09-21
申请人： SurModics, Inc.
发明人： VARNER, Signe, E. , BEELEY, Nathan, R., F. , CHUDZIK, Stephen, J. , BURKSTRAND, Michael, J.
IPC分类号： A61L27/20 , A61K9/00
CPC分类号： A61L27/20 , A61F9/0008 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61L24/08 , A61L31/042 , A61L31/148 , C08L5/16
摘要： In vivo formed matrices including natural biodegradable polysaccharides are described. The matrix is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The matrix can also include a bioactive agent that can be released to provide a therapeutic effect to a patient. The formed matrices are particularly useful for treatment of the eye.

4. 发明公开

EP1926504A1 COATINGS AND ARTICLES INCLUDING NATURAL BIODEGRADABLE POLYSACCHARIDES 有权
标题翻译：拥有自然生物降解多糖原位OKKLUSIONSZUSAMMENSETZUNGEN
公开(公告)号：EP1926504A1
公开(公告)日：2008-06-04
申请号：EP06803981.7
申请日：2006-09-21
申请人： SurModics, Inc.
发明人： CHUDZIK, Stephen, J. , CHINN, Joseph, A. , SWAN, Dale, G. , BURKSTRAND, Michael, J. , DUQUETTE, Peter, H.
IPC分类号： A61L27/20 , A61L24/08
CPC分类号： A61L27/20 , A61F9/0008 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61L24/08 , A61L31/042 , A61L31/148 , C08L5/16
摘要： In situ formed biodegradable occlusions including natural biodegradable polysaccharides are described. The matrix is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.

5. 发明公开

EP1613749A2 LIGAND-COUPLED INITIATOR POLYMERS AND METHODS OF USE 有权
标题翻译：配体耦合引发剂聚合物和申请流程。
公开(公告)号：EP1613749A2
公开(公告)日：2006-01-11
申请号：EP04719790.0
申请日：2004-03-11
申请人： SurModics, Inc.
发明人： CHUDZIK, Stephen, J. , SWAN, Dale, G.
IPC分类号： C12N11/08
CPC分类号： A61K9/5026 , A61K9/1635 , A61K47/32 , Y10S516/911 , Y10S522/904 , Y10S623/92
摘要： Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

6. 发明授权

EP1926504B1 IN SITU OCCLUDING COMPOSITIONS NCLUDING NATURAL BIODEGRADABLE POLYSACCHARIDES 有权
标题翻译：拥有自然生物降解多糖原位OKKLUSIONSZUSAMMENSETZUNGEN
公开(公告)号：EP1926504B1
公开(公告)日：2010-01-13
申请号：EP06803981.7
申请日：2006-09-21
申请人： SurModics, Inc.
发明人： CHUDZIK, Stephen, J. , CHINN, Joseph, A. , SWAN, Dale, G. , BURKSTRAND, Michael, J. , DUQUETTE, Peter, H.
IPC分类号： A61L24/08
CPC分类号： A61L27/20 , A61F9/0008 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61L24/08 , A61L31/042 , A61L31/148 , C08L5/16
摘要： In situ formed biodegradable occlusions including natural biodegradable polysaccharides are described. The matrix is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.

7. 发明公开

EP2004252A2 HYDROPHOBIC DERIVATIVES OF NATURAL BIODEGRADABLE POLYSACCHARIDES AND USES THEREOF 审中-公开
标题翻译：生物降解性天然多糖和使用疏水衍生物
公开(公告)号：EP2004252A2
公开(公告)日：2008-12-24
申请号：EP07753120.0
申请日：2007-03-15
申请人： SurModics, Inc.
发明人： CHUDZIK, Stephen, J. , MISSLING, Jeffrey, J. , VARNER, Signe, E.
IPC分类号： A61L31/04 , A61L31/10 , A61L31/14 , A61L31/16 , A61F9/00 , A61K9/00
CPC分类号： A61L31/16 , A61F9/0017 , A61K9/0024 , A61K9/0051 , A61L27/20 , A61L27/54 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/41 , A61L2300/604 , A61L2300/606 , C08B30/18 , C08L3/02 , C08L5/16
摘要： Hydrophobic derivatives of natural biodegradable polymers and uses thereof are described. The derivatives are exemplified by low molecular weight hydrophobic derivatives of α(1→4)glucopyranose polymers and non-reducing polysaccharides. The hydrophobic polysaccharides can be formed matrices for various uses, including body members of implantable articles, coatings, and consumer items. The matrices have desirable properties, which are advantageous for use in vivo.

8. 发明公开

EP1937327A1 NATURAL BIODEGRADABLE MATRICES AND USES THEREOF 有权
标题翻译：自然科学生物可降解基质和用途
公开(公告)号：EP1937327A1
公开(公告)日：2008-07-02
申请号：EP06815123.2
申请日：2006-09-21
申请人： SurModics, Inc.
发明人： CHUDZIK, Stephen, J. , BURKSTRAND, Michael, J. , SWAN, Dale, G. , CHINN, Joseph, A.
IPC分类号： A61L31/04 , A61L31/14 , A61L31/16 , A61L31/10
CPC分类号： A61L27/20 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61K47/34 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/604 , A61L2300/606 , A61L2420/02 , B05D1/36 , B05D7/52 , C08B31/006 , C08B31/04 , C08B33/02 , C08B33/04 , C08L3/02 , C08L3/12 , C09D103/02 , C09D103/18
摘要： Matrices formed from a natural biodegradable material and that exhibit surface degradation in the presence of an enzyme are described. Matrices including a bioactive agent can be implanted or formed in a subject for release of the bioactive agent upon degradation of the matrix. The matrix can be provided in various forms, including coatings for implantable devices, implants, and in-situ formed matrices. The matrix can also be in the form of a medical device having a structure that is used to treat a medical condition.

9. 发明授权

EP1131167B1 WATER-SOLUBLE COATING AGENTS BEARING INITIATOR GROUPS AND COATING PROCESS 有权
标题翻译：开始基，积水可溶性包衣剂和涂装工艺
公开(公告)号：EP1131167B1
公开(公告)日：2004-07-07
申请号：EP99949672.2
申请日：1999-09-22
申请人： SurModics, Inc.
发明人： SWAN, Dale, G. , AMOS, Richard, A. , EVERSON, Terrence, P. , CHUDZIK, Stephen, J. , CHAPPA, Ralph, A. , STUCKE, Sean, M. , DUQUETTE, Peter, H.
IPC分类号： B05D3/06 , B05D1/00 , C07C309/42
CPC分类号： C08J7/18 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/10 , A61L33/06 , A61L33/12 , B05D1/00 , B05D3/06 , B05D3/061 , B05D3/067 , B05D7/52 , G01N33/54353 , G01N33/54393 , Y10T428/31855

10. 发明公开

EP1395301A1 CROSSLINKABLE MACROMERS 审中-公开
标题翻译：联网大分子
公开(公告)号：EP1395301A1
公开(公告)日：2004-03-10
申请号：EP01942016.5
申请日：2001-06-07
申请人： SurModics, Inc.
发明人： CHUDZIK, Stephen, J. , CLAPPER, David, L.
IPC分类号： A61L27/34 , A61L31/10 , A61L24/00
CPC分类号： A61L31/10 , A61L24/0031 , A61L27/34 , C08L89/06 , C08L5/00
摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the corsslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

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