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1. 发明公开

EP0845534A3 Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：EP0845534A3
公开(公告)日：1999-11-10
申请号：EP97120960.6
申请日：1997-11-28
申请人： Sumitomo Chemical Company, Limited
发明人： Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12N15/55 , C12N9/18 , C12P41/00 , C12P7/38 , C12N1/21
CPC分类号： C12P7/38 , C12N9/18 , C12P41/004
摘要： Described is a gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I:
wherein R 1 is hydrogen or methyl, and R 2 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 1 -C 4 haloalkyl, a C 5 -C 9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C 5 -C 9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, an esterase encoded by said gene as well as methods for its production and its use for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals, insecticides or other active products.

2. 发明公开

EP0869185A2 Production of optically active sphingoid compound 失效
标题翻译： Herstellung von eienr optisch-aktiven Sphingoid-Verbindung
公开(公告)号：EP0869185A2
公开(公告)日：1998-10-07
申请号：EP98103744.3
申请日：1998-03-03
申请人： Sumitomo Chemical Company, Limited
发明人： Ohta, Hiromichi , Sugai, Takeshi , Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12P41/00 , C12P13/02 , C07C233/17
CPC分类号： C07C233/17 , C12N9/18 , C12P13/02 , C12P41/004
摘要： An industrially advantageous production method of an optically active alcohol useful for cosmetics and medical supplies or production intermediates thereof using an esterase having an ability to selectively hydrolyze an optically active sphingoid compound.
摘要翻译：使用具有选择性水解光学活性鞘氨醇化合物的能力的酯酶的可用于化妆品和医疗用品的光学活性醇或其制备中间体的工业上有利的制备方法。

3. 发明公开

EP0959139A1 Method for producing optically active cyclopropanecarboxylic acid 审中-公开
标题翻译： Verfahren zur Herstellung optisch aktiverCyclopropancarbonsäure
公开(公告)号：EP0959139A1
公开(公告)日：1999-11-24
申请号：EP99109557.1
申请日：1999-05-12
申请人： Sumitomo Chemical Company, Limited
发明人： Fukita, Yoshikazu , Ishii, Takeshi , Asako, Hiroyuki
IPC分类号： C12P41/00 , C12P7/40
CPC分类号： C12P7/40 , C12P41/005
摘要： The objective of the present invention is to provide a method which makes it possible to produce (1R)-trans-2,2-dimethyl-3-(substituted vinyl)cyclopropane-1-carboxylic acid which is useful as the acid component of a pyrethroid ester in an industrially advantageous way.
This objective is achieved by a method for producing (1R)-trans-2,2-dimethyl-3-(substituted vinyl) cyclopropane-1-carboxylic acid, comprising reacting with 2,2-dimethyl-3-(substituted vinyl)cyclopropane-1-carboxylic acid esters represented by the general formula:
(wherein X is a hydrogen atom or a chlorine atom; Y is a methyl group when X is a hydrogen atom, whereas Y is a methyl group or a fluorine atom when X is a chlorine atom; and R is a C 1 -C 4 alkyl group) an esterase capable of acting on and asymmetrically hydrolyzing the ester corresponding to (1R)-trans-2,2-dimethyl-3-(substituted vinyl)cyclopropan-1-carboxylic acid and leaving the remaining esters of the diastereomers unreacted so that said esters can be resolved from (1R)-trans-2,2-dimethyl-3-(substituted vinyl)cyclopropane-1-carboxylic acid and esters of diastereomers thereof; and isolating and recovering the (1R)-trans-2,2-dimethyl-3-(substituted vinyl)cyclopropane-1-carboxylic acid.
摘要翻译：本发明的目的是提供一种可以制备可用作酸性成分的（1R） - 反式-2,2-二甲基-3-（取代的乙烯基）环丙烷-1-羧酸的方法拟除虫菊酯在工业上有利的方式。该目的通过制备（1R） - 反式-2,2-二甲基-3-（取代的乙烯基）环丙烷-1-羧酸的方法来实现，该方法包括与2,2-二甲基-3-（取代的乙烯基）环丙烷由以下通式表示的1-羧酸酯：其中X是氢原子或氯原子，当X是氢原子时，Y是甲基，而Y是甲基或氟原子，当 X为氯原子，R为C1-C4烷基）能够作用于对称（1R） - 反式-2,2-二甲基-3-（取代乙烯基）环丙烷-1 （1R） - 反式-2,2-二甲基-3-（取代的乙烯基）环丙烷-1-羧酸及其非对映异构体的酯分离; 并分离并回收（1R） - 反式-2,2-二甲基-3-（取代的乙烯基）环丙烷-1-羧酸。

4. 发明公开

EP0869185A3 Production of optically active sphingoid compound 失效
标题翻译： eienr光学活性类鞘氨醇化合物的制备
公开(公告)号：EP0869185A3
公开(公告)日：1999-11-17
申请号：EP98103744.3
申请日：1998-03-03
申请人： Sumitomo Chemical Company, Limited
发明人： Ohta, Hiromichi , Sugai, Takeshi , Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12P41/00 , C12P13/02 , C07C233/17
CPC分类号： C07C233/17 , C12N9/18 , C12P13/02 , C12P41/004
摘要： An industrially advantageous production method of an optically active alcohol useful for cosmetics and medical supplies or production intermediates thereof using an esterase having an ability to selectively hydrolyze an optically active sphingoid compound.

5. 发明公开

EP0846768A2 Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：EP0846768A2
公开(公告)日：1998-06-10
申请号：EP97120959.8
申请日：1997-11-28
申请人： Sumitomo Chemical Company, Limited
发明人： Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12N15/55 , C12N9/18 , C12P41/00 , C12P7/38 , C12N1/21
CPC分类号： C12P7/26 , C12N9/18 , C12P7/38 , C12P41/004
摘要： A gene is described coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I:
wherein R 1 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl or C 1 -C 4 haloalkyl, to produce the cyclopentenolone of formula I in (S)-form; an esterase encoded by said gene and methods for its production as well as its use for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals, insecticides or other active products.
摘要翻译：描述了编码能够引起式I的环戊烯醇酮的有机羧酸酯的不对称水解的酯酶的基因：其中R 1为C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基或C 1 -C 4卤代烷基，以（S）形式制备式I的环戊烯醇酮; 由所述基因编码的酯酶及其制备方法以及其用于工业上有利地制备用作药物，农药，杀虫剂或其它活性产物的中间体的式I的光学活性环戊烯醇酮的用途。

6. 发明公开

EP0845534A2 Esterase gene and its use 失效
标题翻译： Esterase Gen和dessen Verwendung
公开(公告)号：EP0845534A2
公开(公告)日：1998-06-03
申请号：EP97120960.6
申请日：1997-11-28
申请人： Sumitomo Chemical Company, Limited
发明人： Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12N15/55 , C12N9/18 , C12P41/00 , C12P7/38 , C12N1/21
CPC分类号： C12P7/38 , C12N9/18 , C12P41/004
摘要： Described is a gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I:
wherein R 1 is hydrogen or methyl, and R 2 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 1 -C 4 haloalkyl, a C 5 -C 9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C 5 -C 9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, an esterase encoded by said gene as well as methods for its production and its use for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals, insecticides or other active products.
摘要翻译：描述了编码能够引起式I的环戊烯醇酮的有机羧酸酯的不对称水解的酯酶：其中R1是氢或甲基，R2是C1-C10烷基，C2-C10链烯基，C2 -C 10炔基，C 1 -C 4卤代烷基，可以任选地保护在其末端羟基上的C 5 -C 9脂族烃部分或可以任选地保护在其末端羧基上的C5-C9脂肪酸残基，以产生（R）形式的式I的环戊烯醇酮，由所述基因编码的酯酶以及其制备方法及其在工业上有利地生产作为药物中间体的式I的光学活性环戊烯酮的用途，农药，杀虫剂或其他活性物质。

7. 发明授权

EP0894868B1 Process for producing nucleoside derivatives 失效
标题翻译：一种用于核苷衍生物的制备方法
公开(公告)号：EP0894868B1
公开(公告)日：2005-03-16
申请号：EP98114206.0
申请日：1998-07-29
申请人： Sumitomo Chemical Company, Limited
发明人： Ohta, Hiromichi , Sugai, Takeshi , Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12P19/40 , C12P19/38
CPC分类号： C12P19/385 , C12N9/18 , C12P19/40

8. 发明授权

EP0869185B1 Production of optically active sphingoid compound 失效
标题翻译：光学活性的类鞘氨醇化合物的制备
公开(公告)号：EP0869185B1
公开(公告)日：2003-09-17
申请号：EP98103744.3
申请日：1998-03-03
申请人： Sumitomo Chemical Company, Limited
发明人： Ohta, Hiromichi , Sugai, Takeshi , Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12P41/00 , C12P13/02 , C07C233/17
CPC分类号： C07C233/17 , C12N9/18 , C12P13/02 , C12P41/004

9. 发明公开

EP0846768A3 Esterase gene and its use 失效
公开(公告)号：EP0846768A3
公开(公告)日：1999-11-17
申请号：EP97120959.8
申请日：1997-11-28
申请人： Sumitomo Chemical Company, Limited
发明人： Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12N15/55 , C12N9/18 , C12P41/00 , C12P7/38 , C12N1/21
CPC分类号： C12P7/26 , C12N9/18 , C12P7/38 , C12P41/004
摘要： A gene is described coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I:
wherein R 1 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl or C 1 -C 4 haloalkyl, to produce the cyclopentenolone of formula I in (S)-form; an esterase encoded by said gene and methods for its production as well as its use for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals, insecticides or other active products.

10. 发明公开

EP0894868A3 Process for producing nucleoside derivatives 失效
标题翻译：生产核苷衍生物的方法
公开(公告)号：EP0894868A3
公开(公告)日：1999-04-21
申请号：EP98114206.0
申请日：1998-07-29
申请人： Sumitomo Chemical Company, Limited
发明人： Ohta, Hiromichi , Sugai, Takeshi , Ishii, Takeshi , Mitsuda, Satoshi
IPC分类号： C12P19/40
CPC分类号： C12P19/385 , C12N9/18 , C12P19/40
摘要： There is disclosed a process for producing a nucleoside derivative of the formula [I]:
characterized by contacting 2',3',5'-O-triacylribonucleoside derivative of the formula [II]:
with an ester hydrolase:
(i) capable of regio-selectively deacylating the acyl group at 5'-O-position in the formula [II] above, and (ii) having an amino acid sequence encoded by a gene which hybridizes to a nucleotide sequence encoding an amino acid sequence of SEQ ID NO: 1
摘要翻译：公开了生产式[I]的核苷衍生物的方法：其特征在于使式[II]的2'，3'，5'-O-三酰基核糖核苷衍生物与酯水解酶接触：（i）能够（ii）具有由与编码SEQ ID NO：1的氨基酸序列的核苷酸序列杂交的基因编码的氨基酸序列，所述基因编码的氨基酸序列与上述式[II]中的5'-O-位的酰基基团区域选择性地脱酰基：1

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