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1. 发明公开

EP2616025A1 METHOD FOR PERFORMING A REVERSIBLE REFRACTIVE PROCEDURE 审中-公开
标题翻译：方法用于执行可逆屈光手术
公开(公告)号：EP2616025A1
公开(公告)日：2013-07-24
申请号：EP11824649.5
申请日：2011-09-13
申请人： Singapore Health Services Pte Ltd
发明人： TAN, Donald , MEHTA, Jodhbir
IPC分类号： A61F9/01 , A61F9/013
CPC分类号： A61F9/00834 , A01N1/0226 , A61F2/145 , A61F2/16 , A61F9/00831 , A61F9/013 , A61F2009/00872 , A61F2009/0088 , A61F2009/00895
摘要： The present invention is directed to a method for performing a reversible refractive procedure by reimplanting a refractive lenticule that has been obtained by a refractive procedure on the eye, the method comprising the steps of preparing the refractive lenticule for reimplantation, creating a corneal flap in an eye of an acceptor, transferring the refractive lenticule under the corneal flap, and repositioning and covering the acceptor's corneal flap; thereby reimplanting the refractive lenticule. The present invention is also directed to a refractive lenticule obtained by a refractive procedure on the eye of a donor for use in a method for subsequent reimplantation in a reversible refractive procedure on an acceptor, wherein the refractive lenticule is stored at a temperature below 0°C.

2. 发明公开

EP3288445A1 A SIGNAL COMPENSATION OPTICAL COHERENCE TOMOGRAPHY SYSTEM AND METHOD 审中-公开
标题翻译：信号补偿光学相干层析成像系统和方法
公开(公告)号：EP3288445A1
公开(公告)日：2018-03-07
申请号：EP16786857.9
申请日：2016-04-29
申请人： National University of Singapore , University Of French Polynesia , Singapore Health Services Pte. Ltd. , Moorfields Eye Hospital
发明人： STROUTHIDIS, Nicholas , GIRARD, Michael Julien Alexandre , MARI, Jean Martial , MEHTA, Jodhbir , NICOLAS, Foin
IPC分类号： A61B5/00 , G06T5/00 , G06T1/00
CPC分类号： A61B5/0066 , A61B3/102 , A61B5/0084 , A61B5/02007 , A61B5/7264 , A61B5/742 , A61B2576/00 , G01B9/02091
摘要： An optical coherence tomography system and method. The system comprises a detector for detecting an optical coherence tomography signals from a sample; a processing unit for converting the detected signals to raw data; a compensation unit for performing compensation to generate compensated data; and a display for displaying at least the compensated data.

3. 发明公开

EP2875124A1 CELL CULTURE OF CORNEAL ENDOTHELIAL CELLS 有权
标题翻译：角膜内皮细胞培养
公开(公告)号：EP2875124A1
公开(公告)日：2015-05-27
申请号：EP13820042.3
申请日：2013-07-18
申请人： Singapore Health Services Pte Ltd
发明人： TAN, Donald , MEHTA, Jodhbir , PEH, Swee Lim Gary
IPC分类号： C12N5/071 , C12N5/02
CPC分类号： C12N5/0621 , C12N2500/24 , C12N2500/25 , C12N2500/30 , C12N2500/32 , C12N2500/34 , C12N2500/38 , C12N2500/62 , C12N2500/72 , C12N2500/80 , C12N2501/06 , C12N2501/10 , C12N2501/31 , C12N2501/33 , C12N2501/39
摘要： The invention relates to a dual-media approach for culturing isolated corneal endothelial cells. Isolated corneal endothelial cells are first contacted with a proliferative medium to propagate and/or expand the endothelial cells followed by a maintenance medium to preserve the morphology and/or characteristics of the corneal endothelial cells. The invention includes the proliferative medium and the maintenance medium and also a combination of the two medium.

4. 发明公开

EP3490497A1 OPTICAL CYLINDER AND METHOD OF SURFACE TREATMENT OF THE SAME 审中-公开
公开(公告)号：EP3490497A1
公开(公告)日：2019-06-05
申请号：EP17834874.4
申请日：2017-07-26
申请人： Singapore Health Services Pte Ltd , Nanyang Technological University
发明人： MEHTA, Jodhbir , RIAU, Andri , VENKATRAMAN, Subramanian , LIEDBERG, Bo , MONDAL, Debasish
IPC分类号： A61F2/14

5. 发明公开

EP3047018A1 CORNEAL STROMAL KERATOCYTE CULTURE 审中-公开
标题翻译： HORNHAUT - 间质KERATOZYTENKULTUR
公开(公告)号：EP3047018A1
公开(公告)日：2016-07-27
申请号：EP14845539.7
申请日：2014-09-17
申请人： Singapore Health Services Pte Ltd
发明人： YAM, Hin-Fai, Gary , MEHTA, Jodhbir
IPC分类号： C12N5/071 , C12N5/02
CPC分类号： C12N5/0621 , C12N2500/84 , C12N2501/105 , C12N2501/727 , C12N2502/025 , C12N2533/54
摘要： The present invention relates to corneal stromal keratocytes (CSKs) culture. In particular the present invention relates to a method for culturing corneal stromal keratocytes ex vivo. The method utilises a dual culture medium protocol. In the presence of serum (in particular low serum concentration) in a first culture medium A, the "activated keratoctyes" are expandable while specific CSK gene expression is maintained in serum-free ERI condition in a second culture medium B. The invention also relates to culture medium A and B which is supplemented with liquid amnion extract or other additional supplements. This protocol also applied to CSK from other species. Additionally, the present invention provides method for CSK cultivation to provide sufficient quantity of genuine CSKs for corneal tissue engineering without a risk of fibroblastic changes.
摘要翻译：本发明涉及角膜基质角化细胞（CSKs）培养。特别地，本发明涉及离体培养角膜基质角膜细胞的方法。该方法采用双重培养基方案。在第一培养基A中存在血清（特别是低血清浓度）的情况下，第二培养基B中“活化的角质细胞”是可扩展的，而特异性CSK基因表达维持在无血清ERI条件下。本发明还涉及到补充有液体羊膜提取物或其他补充剂的培养基A和B。该协议也适用于其他物种的CSK。另外，本发明提供了CSK培养方法，以提供足够数量的用于角膜组织工程的真正的CSK，而没有成纤维细胞变化的风险。

6. 发明授权

EP2875124B1 CELL CULTURE OF CORNEAL ENDOTHELIAL CELLS 有权
公开(公告)号：EP2875124B1
公开(公告)日：2019-03-27
申请号：EP13820042.3
申请日：2013-07-18
申请人： Singapore Health Services Pte Ltd
发明人： TAN, Donald , MEHTA, Jodhbir , PEH, Swee Lim Gary
IPC分类号： C12N5/071 , C12N5/02 , C12N5/079

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