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1. 发明公开

EP3189835A1 MEDICAL AGENT FOR SUPPRESSING MALIGNANT TUMOR METASTASIS 有权
标题翻译：用于抑制恶性肿瘤转移的医疗剂
公开(公告)号：EP3189835A1
公开(公告)日：2017-07-12
申请号：EP17153823.4
申请日：2012-02-27
申请人： National Cerebral and Cardiovascular Center , OSAKA UNIVERSITY , Shionogi & Co., Ltd.
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi , OKUMURA, Meinoshin
IPC分类号： A61K31/167 , A61K38/22 , A61P25/00
CPC分类号： A61K38/22 , A61K31/167 , A61K38/2242 , A61K39/3955 , A61K45/06 , C07K14/58 , C07K2319/30 , C07K2319/31 , A61K2300/00
摘要： The present invention relates to a natriuretic peptide receptor GC-B agonist for use in preventing or suppressing the metastasis of a malignant tumor, wherein the natriuretic peptide receptor GC-B agonist is any one selected from the following (b1) to (b5) or a pharmacologically acceptable salt thereof and has an agonist activity for the natriuretic peptide receptor GC-B: (b1) a c-type natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 7, 8, 9 or 10, (b2) a substance comprising an active fragment, where in it has the amino acid sequence of SEQ ID NO: 11, or wherein it consists of the amino acid sequence from position 6 to position 22 of SEQ ID NO: 7, (b3) a mutant wherein it is (i) a peptide consisting of the amino acid sequence of SEQ ID NO: 7, 9 or 10 having substitution, deletion, insertion, and/or addition of one to several amino acids selected from positions 1 to 5, (ii) a peptide consisting of the amino acid sequence of SEQ ID NO: 8 having substitution, deletion, insertion, and/or addition of one to several amino acids at any one to several positions selected from positions 1 to 36: (b4) a derivative comprising any one of the amino acid sequences of SEQ ID Nos: 7 to 11, wherein the derivative preferably further comprises at least one of the Fc region of an immunoglobulin, a serum albumin, and the C-terminus of ghrelin, and (b5) a modified form wherein it comprises any one of the amino acid sequences of SEQ ID Nos: 7 to 10 of the sequence listing, and at least one amino acid other than the amino acids shown in SEQ ID NO: 11 is chemically modified, or wherein it is prepared by chemical modification by addition of a pharmaceutically usable polymer.
摘要翻译：本发明涉及用于预防或抑制恶性肿瘤的转移的利尿钠肽受体GC-B激动剂，其中钠利尿肽受体GC-B激动剂是选自以下（b1）至（b5）或（b1）由SEQ ID NO：7,8,9或10的氨基酸序列组成的c型利尿钠肽，（b2）由利钠肽受体GC-B的激动剂活性包含活性片段的物质，其中它具有SEQ ID NO：11的氨基酸序列，或其中它由SEQ ID NO：7的6位至22位的氨基酸序列组成，（b3）突变体，其中（i）由选自1至5位的一个至数个氨基酸取代，缺失，插入和/或添加的由SEQ ID NO：7,9或10的氨基酸序列组成的肽，（ii）由具有取代，缺失的SEQ ID NO：8的氨基酸序列组成的肽（b4）包含SEQ ID No：7至11的氨基酸序列中的任何一个的衍生物，其中在选自1至36位的任何一个至数个位置处具有一个至数个氨基酸的离子，插入和/ 该衍生物优选进一步包含免疫球蛋白的Fc区，血清白蛋白和生长素释放肽的C-末端中的至少一个，和（b5）其中它包含SEQ ID Nos：序列表7至10中的至少一个氨基酸以及SEQ ID NO：11中所示的氨基酸以外的至少一个氨基酸被化学修饰，或者其中通过添加可药用聚合物通过化学修饰来制备。

2. 发明公开

EP2905029A1 DRUG FOR INHIBITING MALIGNANT TUMOR METASTASIS 审中-公开
标题翻译：药品的抑制肿瘤转移
公开(公告)号：EP2905029A1
公开(公告)日：2015-08-12
申请号：EP13843851.0
申请日：2013-10-04
申请人： Shionogi & Co., Ltd. , National Cerebral and Cardiovascular Center
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi
IPC分类号： A61K38/00 , A61K31/4184 , A61K31/47 , A61K33/24 , A61K45/00 , A61P35/04 , A61P43/00
CPC分类号： A61K38/25 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/4245 , A61K31/47 , A61K31/473 , A61K31/555 , A61K33/24 , A61K38/22 , A61K45/06 , A61K2300/00
摘要： A medicinal composition for suppressing or preventing the metastasis of a malignant tumor, the composition comprising, as an active ingredient, at least one kind of vasoprotective agent selected from the following (i) to (iv) : (i) angiotensin II receptor antagonist, (ii) HMG-CoA reductase inhibitor, (iii) ghrelin or its derivative, and (iv) adrenomedullin or its derivative; or a pharmacologically acceptable salt thereof.

3. 发明授权

EP2905029B1 DRUG FOR INHIBITING MALIGNANT TUMOR METASTASIS 有权
公开(公告)号：EP2905029B1
公开(公告)日：2018-11-21
申请号：EP13843851.0
申请日：2013-10-04
申请人： Shionogi & Co., Ltd. , National Cerebral and Cardiovascular Center
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi
IPC分类号： A61K38/22 , A61K38/25 , A61K45/06 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/4245 , A61K31/47 , A61K31/473 , A61K31/555 , A61K33/24 , A61P35/04 , A61P43/00
CPC分类号： A61K38/25 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/4245 , A61K31/47 , A61K31/473 , A61K31/555 , A61K33/24 , A61K38/22 , A61K45/06 , A61K2300/00
摘要： A medicinal composition for suppressing or preventing the metastasis of a malignant tumor, the composition comprising, as an active ingredient, at least one kind of vasoprotective agent selected from the following (i) to (iv) : (i) angiotensin II receptor antagonist, (ii) HMG-CoA reductase inhibitor, (iii) ghrelin or its derivative, and (iv) adrenomedullin or its derivative; or a pharmacologically acceptable salt thereof.

4. 发明授权

EP3189835B1 MEDICAL AGENT FOR SUPPRESSING MALIGNANT TUMOR METASTASIS 有权
公开(公告)号：EP3189835B1
公开(公告)日：2018-07-25
申请号：EP17153823.4
申请日：2012-02-27
申请人： National Cerebral and Cardiovascular Center , OSAKA UNIVERSITY , Shionogi & Co., Ltd.
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi , OKUMURA, Meinoshin
IPC分类号： A61K31/167 , A61K38/22 , A61P25/00
CPC分类号： A61K38/22 , A61K31/167 , A61K38/2242 , A61K39/3955 , A61K45/06 , C07K14/58 , C07K2319/30 , C07K2319/31 , A61K2300/00
摘要： A medicinal agent for suppressing or preventing the metastasis of a malignant tumor, the agent comprising, as an active ingredient, at least one kind of vascular endothelial intracellular cGMP enhancer.

5. 发明授权

EP2682128B1 ATRIAL NATRIURETIC PEPTIDE OR BRAIN NATRIURETIC PEPTIDE FOR USE IN PREVENTING METASTASIS 有权
标题翻译：用于预防转移的心房利钠肽或脑钠能利托肽
公开(公告)号：EP2682128B1
公开(公告)日：2017-11-08
申请号：EP12752973.3
申请日：2012-02-27
申请人： National Cerebral and Cardiovascular Center , Osaka University , Shionogi & Co., Ltd.
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi , OKUMURA, Meinoshin
IPC分类号： A61K45/00 , A61K38/00 , A61K38/22 , A61K39/395 , A61P35/04 , A61P43/00 , C07K14/58
CPC分类号： A61K38/22 , A61K31/167 , A61K38/2242 , A61K39/3955 , A61K45/06 , C07K14/58 , C07K2319/30 , C07K2319/31 , A61K2300/00

6. 发明公开

EP3360573A1 MEDICINAL DRUG FOR PREVENTING OR INHIBITING ACUTE KIDNEY INJURY 无效
公开(公告)号：EP3360573A1
公开(公告)日：2018-08-15
申请号：EP16853615.9
申请日：2016-10-05
申请人： National Cerebral and Cardiovascular Center
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi
IPC分类号： A61K45/00 , A61K31/18 , A61K31/381 , A61K31/44 , A61K45/06 , A61P13/12
CPC分类号： A61K31/18 , A61K31/34 , A61K31/381 , A61K31/44 , A61K45/00 , A61K45/06 , A61K2300/00 , A61P13/12
摘要： The present invention provides a novel medicament for preventing or inhibiting acute kidney injury, the medicament comprising, as an active ingredient, an angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof, and being used for treatment or prevention of acute kidney injury. Also, the present invention provides a novel method for preventing or inhibiting acute kidney injury, the method comprising administering, to a patient, an effective amount of an angiotensin II receptor type 2 agonist or a pharmacologically acceptable salt thereof in combination with an anticancer agent and/or an antitumor agent.

7. 发明公开

EP3127554A1 MEDICINE FOR SUPPRESSING MALIGNANT TUMOR METASTASIS 审中-公开
标题翻译： ARZNEIMITTEL ZUR HEMMUNG MALIGNER TUMORMETASTASEN
公开(公告)号：EP3127554A1
公开(公告)日：2017-02-08
申请号：EP15773890.7
申请日：2015-04-03
申请人： National Cerebral and Cardiovascular Center , Mitsubishi Tanabe Pharma Corporation
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi
IPC分类号： A61K45/00 , A61K31/18 , A61P35/04 , A61P43/00
CPC分类号： A61K31/5375 , A61K9/0053 , A61K31/18 , A61K31/192 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/438 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/454 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/554 , A61K45/06
摘要： Provided are a novel medicament for suppressing or preventing the metastasis of a malignant tumor such as carcinoma, a novel treatment or prevention method for suppressing or preventing the metastasis of a malignant tumor, etc. The medicament comprises a non-peptidic angiotensin type 2 receptor agonist as an active ingredient. In the medicament, the non-peptidic angiotensin type 2 receptor agonist may be, for example, a sulfonyl malonamide compound. The medicament may be a medicament for use in combination with an anticancer agent and/or an antitumor agent.
摘要翻译：提供了用于抑制或预防恶性肿瘤如癌的转移的新型药物，用于抑制或预防恶性肿瘤转移的新型治疗或预防方法等。该药物包含非肽类血管紧张素2型受体激动剂作为活性成分。在药物中，非肽类血管紧张素2型受体激动剂可以是例如磺酰丙酰胺化合物。药物可以是与抗癌剂和/或抗肿瘤剂组合使用的药物。

8. 发明授权

EP1829969B1 NOVEL POLYPEPTIDE AND THE USE THEREOF 有权
标题翻译：新的多肽及其用途
公开(公告)号：EP1829969B1
公开(公告)日：2012-11-28
申请号：EP05822348.8
申请日：2005-12-22
申请人： National Cerebral and Cardiovascular Center , Takeda Pharmaceutical Company Limited
发明人： KANGAWA, Kenji , MORI, Kenji , MIYAZATO, Mikiya , KOJIMA, Masayasu
IPC分类号： A61K38/17 , C07K14/47 , G01N33/68 , G01N33/94
CPC分类号： G01N33/9406 , A01K2217/05 , A01K2227/10 , A61K38/17 , C07K14/47 , G01N33/6893 , G01N2500/00 , G01N2800/046 , G01N2800/306 , G01N2800/362 , G01N2800/367

9. 发明授权

EP1878436B1 METHOD FOR REGENERATING AND REPAIRING DAMAGED TISSUES USING ADRENOMEDULLIN 无效
标题翻译：再生或修复的方法破坏的组织与肾上腺髓质素
公开(公告)号：EP1878436B1
公开(公告)日：2014-07-23
申请号：EP06728690.6
申请日：2006-03-07
申请人： National Cerebral and Cardiovascular Center , Hubit Genomix, Inc.
发明人： NAGAYA, Noritoshi , MIYATAKE, Kunio , KANGAWA, Kenji , MURAKAMI, Shinsuke
IPC分类号： A61K38/00 , A61P1/16 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/12 , A61P43/00
CPC分类号： A61K38/22

10. 发明公开

EP2745846A1 DRUG FOR PREVENTING EXACERBATION OF MALIGNANT TUMOR, COMPRISING COMBINATION OF NATRIURETIC PEPTIDE RECEPTOR GC-A AGONIST AND GC-B AGONIST 审中-公开
标题翻译：药物用于预防恶性肿瘤的加重与利钠肽受体激动剂和GC甲GC-B激动剂的组合
公开(公告)号：EP2745846A1
公开(公告)日：2014-06-25
申请号：EP12825866.2
申请日：2012-08-17
申请人： National Cerebral and Cardiovascular Center , Osaka University , Daiichi Sankyo Company, Limited
发明人： KANGAWA, Kenji , HOSODA, Hiroshi , NOJIRI, Takashi , OKUMURA, Meinoshin , FURUYA, Mayumi
IPC分类号： A61K45/06 , A61K38/00 , A61K38/22 , A61P35/00
CPC分类号： A61K38/22 , A61K38/2242 , A61K45/06 , A61K2300/00
摘要： Provided are a medicinal agent which is highly safe for use as the treatment of a malignant tumor and is capable of efficiently treating a malignant tumor, that is, a medicinal agent for treating a malignant tumor or for suppressing or preventing the exacerbation thereof, comprising at least one kind of natriuretic peptide receptor GC-A agonist and at least one kind of natriuretic peptide receptor GC-B agonist to be administered in combination; a therapeutic method comprising administering the agent; etc.

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