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1. 发明公开

EP2404903A1 METHOD OF SYNTHESIZING [18F]SFB USING MICROSYNTHESIS TECHNIQUE 有权
标题翻译：使用显微合成技术合成[18F] SFB的方法
公开(公告)号：EP2404903A1
公开(公告)日：2012-01-11
申请号：EP10748713.4
申请日：2010-03-01
申请人： Shimadzu Corporation , Kyoto University
发明人： NAKANISHI Hiroaki , SAIKI Hidekazu , SAJI Hideo , KIMURA Hiroyuki , KAWASHIMA Hidekazu , TOMATSU Kenji , KUGE Yuji
IPC分类号： C07D207/404 , A61K51/00 , C07B59/00 , C07B61/00
CPC分类号： C07D207/404 , A61K51/00 , C07B59/001 , C07B59/002
摘要： A method for synthesizing [ 18 F]SFB is disclosed, which comprises using a microreactor including a substrate having one channel formed therein so as to have a cross-sectional width of 1 mm or less and a cross-sectional depth of 1 mm or less, the channel being connected to a raw material injection port and a first reagent injection port at one end thereof, and connected to a second reagent injection port at a position far from the one end thereof, and connected to a third reagent injection port at a position far from the second reagent injection port in a direction toward another end thereof, and connected to a liquid discharge port at the other end thereof; and continuously performing a three-step reaction by allowing a reaction solution to flow through the channel serving as a reaction channel from the one end to the other end thereof without taking out the reaction solution from anywhere between the one end and the other end of the channel.
摘要翻译：公开了一种用于合成[18 F] SFB的方法，其包括使用微反应器，该微反应器包括其中形成有一个通道的基板，从而具有1mm或更小的横截面宽度和1mm或更小的横截面深度，所述流路的一端与原料注入口及第一试剂注入口连接，在远离一端的位置与第二试剂注入口连接，在第三试剂注入口的位置与第二试剂注入口连接在朝向另一端的方向上远离第二试剂注入口，并且在其另一端连接到液体排出口; 而不从反应溶液的一端到另一端之间的任何地方从反应溶液的一端和另一端之间的任何位置取出反应溶液，从而使反应溶液从反应通道的一端流到另一端而连续地进行三步反应渠道。

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