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1. 发明公开

EP4354144A1 MICROFLUIDIC CHIP FOR TESTING PROTEIN ANTIGEN, AND METHOD, KIT AND SYSTEM 审中-实审
公开(公告)号：EP4354144A1
公开(公告)日：2024-04-17
申请号：EP22860631.5
申请日：2022-08-26
申请人： Shenzhen Yhlo Biotech Co., Ltd.
发明人： CHENG, Bangning , LI, Shunji , LIU, Bifeng , QIAN, Chungen , XIAO, Yujin , CHEN, Peng
IPC分类号： G01N33/68 , G01N33/58 , G01N33/543 , B01L3/00
摘要： The present invention relates to a microfluidic chip, a method, a reagent kit, and a system for detecting protein antigens. The method for detecting protein antigens includes the following steps: mixing a test sample with a reaction reagent, and forming the mixture of the test sample and the reaction reagent into a plurality of liquid droplets through microfluidic control technology, wherein the reaction reagent includes marker-labeled antibodies and an electrolyte providing agent, the marker-labeled antibodies are adapted to specifically bind to protein antigens in the test sample, forming the plurality of antigen-antibody complexes, the plurality of antigen-antibody complexes are encapsulated within the liquid droplets, and the plurality of antigen-antibody complexes are capable of undergoing agglutination reaction under an action of the electrolyte providing agent; and after the agglutination reaction, detecting and analyzing signal intensities of the liquid droplets corresponding to the agglutination reaction, thereby determining the quantity of the protein antigens in the test sample. The detection method is simple, not requiring washing steps and the plurality of rounds of sample additions, consumes a decreased amount of reagent with high reproducibility.

2. 发明公开

EP4332582A1 REAGENT TRANSFER DEVICE AND IMMUNOLOGICAL DIAGNOSTIC APPARATUS 审中-实审
公开(公告)号：EP4332582A1
公开(公告)日：2024-03-06
申请号：EP22794205.9
申请日：2022-01-19
申请人： Shenzhen Yhlo Biotech Co., Ltd
发明人： MO, Shaohao , HUANG, Xiutao , ZHANG, Fuxing , XIAO, Yujin
IPC分类号： G01N35/04
摘要： A reagent transfer device (10) and an immunological diagnostic apparatus. The reagent transfer device (10) comprises a transfer supporting mechanism (100) and reagent transfer mechanisms (200), wherein a plurality of reagent transfer mechanisms (200) are provided, and the plurality of reagent transfer mechanisms (200) are respectively mounted to the transfer supporting mechanism (100); and each reagent transfer mechanism (200) comprises a transfer base (210), a reagent needle (220) and a multidirectional movement component (230), the transfer base (210) being mounted to the transfer support mechanism (100), the multidirectional movement component (230) being arranged on the transfer base (210), and the multidirectional movement component (230) being connected to the reagent needle (220) so as to drive the reagent needle (220) to move. The immunological diagnostic apparatus comprises the reagent transfer device (10). The reagent transfer device (10) can solve the problems of the low reagent transfer efficiency and low detection efficiency of a chemiluminescence immunoassay system in the prior art.

3. 发明公开

EP4292712A1 MICROFLUIDIC CHIP 审中-实审
公开(公告)号：EP4292712A1
公开(公告)日：2023-12-20
申请号：EP22752092.1
申请日：2022-01-19
申请人： Shenzhen Yhlo Biotech Co., Ltd
发明人： QIAN, Chungen , HUANG, Ming , LIU, Bifeng , CHEN, Peng , XIAO, Yujin , HU, Kunhui
IPC分类号： B01L3/00 , G01N33/00 , G01N33/50 , C12M1/00
摘要： The present invention relates to a microfluidic chip, a reagent output structure thereof comprising a reagent storage chamber, a first centrifugal-force flow channel and a time delay unit. The time delay unit comprises a first diverting flow channel, a capillary-force flow channel, a second diverting flow channel and a second centrifugal-force flow channel. The first centrifugal-force flow channel extends away from the centre of rotation after being led out from the reagent storage chamber, and is in communication with one end of the first diverting flow channel. The other end of the first diverting flow channel is in communication with one end of the capillary-force flow channel, the capillary-force flow channel extends towards the centre of rotation after being led out from the first diverting flow channel, the other end of the capillary-force flow channel is in communication with one end of the second diverting flow channel, the other end of the second diverting flow channel is in communication with the second centrifugal-force flow channel, and the second centrifugal-force flow channel extends away from the centre of rotation after being led out from the second diverting flow channel. The microfluidic chip is suitable for reactions where it is necessary to control the output time and sequence of reagents, and particularly in reactions where it is necessary to sequentially apply a plurality of reagents, the time at which the plurality of reagents are applied can be controlled.

4. 发明公开

EP4300081A1 SAMPLE JOINT INSPECTION AND ANALYSIS SYSTEM 审中-实审
公开(公告)号：EP4300081A1
公开(公告)日：2024-01-03
申请号：EP22758716.9
申请日：2022-01-19
申请人： Shenzhen Yhlo Biotech Co., Ltd.
发明人： ZHANG, Fuxing , XIAO, Yujin , HU, Kunhui
IPC分类号： G01N21/76 , G01N33/50 , G01N33/53 , G01N35/00
摘要： A sample joint inspection and analysis system (10), comprising a rack, and a sample processing apparatus (100), a chemiluminescence immunoassay apparatus (200) and a biochemical analysis apparatus (300) which are arranged on the rack, wherein the sample processing apparatus (100) comprises an immune sample injection channel (110) and a biochemical sample injection channel (120), the immune sample injection channel (110) being in communication with the chemiluminescence immunoassay apparatus (200), and the biochemical sample injection channel (120) being in communication with the biochemical analysis apparatus (300). The sample joint inspection and analysis system (10) has a miniature structure and performs inspection rapidly; multi-item joint inspection based on a biochemical reaction principle and a chemiluminescence inspection principle can be realized; the test advantages of a biochemical reaction and an immune reaction are exploited, and the two test modes do not interfere with each other; the requirements of various medical and inspection institutions or departments for high-throughput and high-sensitivity multiple joint inspection can be met; and multiple options are also provided for a patient.

5. 发明公开

EP3968030A1 METHOD AND APPARATUS FOR AUTOMATIC ENGAGEMENT WITH ANALYZER, COMPUTER DEVICE AND STORAGE MEDIUM 审中-实审
公开(公告)号：EP3968030A1
公开(公告)日：2022-03-16
申请号：EP19931656.3
申请日：2019-12-24
申请人： Shenzhen Yhlo Biotech Co., Ltd.
发明人： XIAO, Yujin , MIN, Liangliang , HU, Kunhui
IPC分类号： G01N35/10 , G01N35/02
摘要： A method and apparatus for automatic engagement with an analyzer, a computer device and a storage medium The method comprises: acquiring test information of a sample under test and state information of an analyzer, the state information indicating whether the analyzer is in an idle state or an operating state (102); if the analyzer is in an idle state, conveying the sample under test to the analyzer (104); and performing a test on the sample under test according to the test information (106). The method can acquire state information of an analyzer to enable a sample under test to be conveyed to the analyzer timely for performing a test thereon without requiring maintenance personnel to adjust the analyzer according to the state information of the analyzer, thereby reducing manual costs and increasing operation efficiency of the analyzer.

6. 发明公开

EP4364850A1 MICROFLUIDIC CHIP 审中-实审
公开(公告)号：EP4364850A1
公开(公告)日：2024-05-08
申请号：EP22860620.8
申请日：2022-08-26
申请人： Shenzhen Yhlo Biotech Co., Ltd
发明人： WEI, Daoshun , CHENG, Xiaoyu , LIU, Bifeng , QIAN, Chungen , XIAO, Yujin , CHEN, Peng
IPC分类号： B01L3/00
摘要： The present invention relates to a microfluidic chip. The microfluidic chip comprises a chip main body and a liquid sac storage piece; a liquid inlet is provided on the chip main body; the liquid sac storage piece is disposed on the chip main body, and a liquid sac cavity used for placing a liquid sac is disposed on the liquid sac storage piece; the liquid sac cavity is provided with a liquid outlet, the liquid outlet communicating with the liquid inlet; and a piercing piece is disposed in the liquid sac cavity; when the liquid sac is placed in the liquid sac cavity, there is a space between the liquid sac and the piercing piece; when the pressing force exerted on the liquid sac exceeds a preset value, the piecing piece can pierce the liquid sac. The described microfluidic chip can reduce the rejection rate of the chip, and improve the test repeatability and stability of the chip.

7. 发明公开

EP4332583A1 REAGENT MIXING AND LOADING DEVICE AND IMMUNOLOGICAL DETECTION APPARATUS 审中-实审
公开(公告)号：EP4332583A1
公开(公告)日：2024-03-06
申请号：EP22794206.7
申请日：2022-01-19
申请人： Shenzhen Yhlo Biotech Co., Ltd
发明人： LAI, Yunfei , HUANG, Xiutao , ZHANG, Fuxing , XIAO, Yujin
IPC分类号： G01N35/04 , G01N1/38 , G01N33/53
摘要： A reagent mixing and loading device (10) and an immunological detection apparatus. The reagent mixing and loading device (10) comprises a transmission mechanism (100), mixing mechanisms (200), a loading mechanism (300) and a driving mechanism (400), wherein the transmission mechanism (100) comprises a first rotating member (110) and a second rotating member (120), the first rotating member (110) being rotatably connected to a plurality of mixing mechanisms (200) arranged at intervals, and the first rotating member (110) being capable of synchronously rotating with the second rotating member (120); the driving mechanism (400) is used to drive the second rotating member (120) to rotate; each mixing mechanism (200) comprises a mixing column (210), a mixing transmission member (220) and a mixing limiting member (230), the mixing transmission member (220) being connected to the mixing column (210) in a sleeved manner and fitting with the second rotating member (120) in an abutting manner; and the loading mechanism (300) comprises a loading box (310) and a loading fitting member (320), the loading box (310) being provided with a reagent hole for the loading box (310) to be placed therein, and the loading fitting member (320) being rotatably arranged in the reagent hole and used for carrying the loading box (310). The reagent mixing and loading device (10) can implement the normal mixing of reagents without the occurrence of problems such as jamming and collision.

8. 发明公开

EP3950107A1 LIQUID DISPENSING PUMP, AND LIQUID DISPENSING DEVICE 有权
公开(公告)号：EP3950107A1
公开(公告)日：2022-02-09
申请号：EP19932461.7
申请日：2019-12-24
申请人： Shenzhen Yhlo Biotech Co., Ltd.
发明人： ZHANG, Fuxing , XIAO, Yujin , HU, Kunhui , QIU, Huanjie
IPC分类号： B01F3/08 , F04B13/02 , B01F15/04 , F04B1/22 , F04B9/109 , F04B9/111
摘要： A liquid dispensing pump (10) comprises: a first liquid storage cylinder (11), a second liquid storage cylinder (12), a first plunger (13) movably connected to the first liquid storage cylinder (11), a second plunger (14) movably connected to the second liquid storage cylinder (12), and a drive assembly (15) connected to the first plunger (13) and the second plunger (14). The first liquid storage cylinder (11) is provided with a first liquid entry and exit port (111). The second liquid storage cylinder (12) is provided with a second liquid entry and exit port (121). One end of the first plunger (13) is inserted into an internal cavity of the first liquid storage cylinder (11). One end of the second plunger (14) is inserted into an internal cavity of the second liquid storage cylinder (12). Further provided is a liquid dispensing device (100). The advantageous effect of the invention is: during each linear reciprocating movement cycle of the first plunger (13) and the second plunger (14), the first liquid storage cylinder (11) and the second liquid storage cylinder (12) discharge corresponding ingredients according to a pre-determined mixing ratio, and a mixed solution according to the pre-determined mixing ratio is obtained, thereby achieving precise mixing of different ingredients. In addition, the dispensing pump (10) discharges ingredients at a consistent ratio, thereby achieving uniform mixing without a dedicated mixer.

9. 发明公开

EP4332581A1 REACTION CUP CONVEYING DEVICE AND IMMUNOLOGICAL DETECTION APPARATUS 审中-实审
公开(公告)号：EP4332581A1
公开(公告)日：2024-03-06
申请号：EP22794204.2
申请日：2022-01-19
申请人： Shenzhen Yhlo Biotech Co., Ltd
发明人： HUANG, Xiutao , CHEN, Shuxiang , ZHANG, Fuxing , XIAO, Yujin
IPC分类号： G01N35/04 , G01N33/53
摘要： A reaction cup conveying device (10). The reaction cup conveying device (10) comprises an inner circular conveying plate body (100), an outer circular conveying plate body (200), reaction cup loading assemblies (300) and a driving mechanism (400), wherein the outer circular conveying plate body (200) is sleeved over the inner circular conveying plate body (100) and can rotate relative to the inner circular conveying plate body (100); the plurality of reaction cup loading assemblies (300) are arranged on a plate surface of the outer circular conveying plate body (200) at intervals; each reaction cup loading assembly (300) is provided with an embedding recess (310) for a reaction cup to be placed therein an embedded manner; and the driving mechanism (400) is connected to the outer circular conveying disc body (200) and is used to drive the outer circular conveying disc body (200) to rotate. The reaction cup conveying device (10) can implement the accurate conveying of a certain number of reaction cups, and solves the problems of the poor positioning accuracy and complex structure of the conveying of reaction cups by means of an outer annular plate body in an existing mechanism.

10. 发明公开

EP4325225A1 REAGENT KIT LOADING AND UNLOADING DEVICE, REAGENT SAMPLING APPARATUS, AND REAGENT KIT LOADING AND UNLOADING METHOD 审中-实审
公开(公告)号：EP4325225A1
公开(公告)日：2024-02-21
申请号：EP22787215.7
申请日：2022-01-04
申请人： Shenzhen Yhlo Biotech Co., Ltd
发明人： HUANG, Xiutao , ZHANG, Fuxing , XIAO, Yujin
IPC分类号： G01N35/00 , G01N35/10
摘要： A reagent kit loading and unloading device (100), a reagent sampling apparatus, and a reagent kit loading and unloading method. The reagent kit loading and unloading device (100) comprises a grabbing mechanism (110) and a conveying mechanism (120), wherein the grabbing mechanism (110) and the conveying mechanism (120) are configured to be close to a reagent disk device (210); the conveying mechanism (120) comprises a conveying driving component (121) and a storage component (122) connected to the conveying driving component (121); the conveying driving component (121) is used for driving the storage component (122) to move so as to convey a reagent kit; the grabbing mechanism (110) comprises a lifting component (111) and a grabbing claw (112) connected to the lifting component (111); and the lifting component (111) is used for driving the grabbing claw (112) to ascend or descend, such that the grabbing claw (112) grabs the reagent kit and transfers same between the reagent disk device (210) and the storage component (122). The reagent kit loading and unloading device (100) can automatically load and unload the reagent kit in an accommodating cavity of the reagent disk device (210), an operator only needs to place the reagent kit on or remove same from the storage component (122), and the operation is simple and convenient.

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