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1. 发明公开

EP4397978A1 METHOD FOR DETECTING ANOMALY IN BLOOD COAGULATION REACTION 审中-公开
公开(公告)号：EP4397978A1
公开(公告)日：2024-07-10
申请号：EP22864560.2
申请日：2022-08-30
申请人： Sekisui Medical Co., Ltd.
发明人： KAWABE, Toshiki , ONISHI, Kengo
IPC分类号： G01N33/86
CPC分类号： G01N33/86
摘要： A method for detecting an anomaly in a blood coagulation reaction, including: 1) detecting a coagulation reaction end point Pe in a coagulation reaction curve of a subject blood specimen; 2) calculating T(X), where T(X) represents a measurement point or time at which the coagulation reaction curve reaches X% of Pe and X denotes a variable larger than 0 and equal to or smaller than 100; and 3) detecting the anomaly in the blood coagulation reaction of the subject blood specimen based on T(X).

2. 发明公开

EP4040161A1 PIERCING CONDITION SELECTION METHOD 审中-实审
公开(公告)号：EP4040161A1
公开(公告)日：2022-08-10
申请号：EP20872753.7
申请日：2020-09-24
申请人： Sekisui Medical Co., Ltd. , Canon Medical Systems Corporation
发明人： KAWABE, Toshiki , OGASAWARA, Kosuke , IIJIMA, Yumi , IWASAKI, Masaaki
IPC分类号： G01N35/02
摘要： Provided are an automatic analysis apparatus capable of realizing a specimen dispensation (CTS) operation of a specimen vessel having a stopper under an appropriate piercing condition according to a type of the specimen vessel having the stopper, and a piercing condition selection method therefor.
An automatic analysis apparatus 1 of the invention includes a rack identification information reading unit 82 for reading rack identification information C assigned to a specimen rack 70, a CTS drive unit 80 for executing a piercing operation of piercing the stopper of the specimen vessel having the stopper at a specimen suction position by a piercer and sucking a specimen in the specimen vessel having the stopper by a specimen suction nozzle passing through a hole of the stopper formed by the piercer, a piercing condition setting unit 82 for setting a piercing operation condition by the piercer for the specimen vessel having the stopper loaded in the specimen rack 70 based on the rack identification information C read by the rack identification information reading unit 84, and a control unit 10 for controlling an operation of the CTS drive unit 80 based on a set piercing operation condition.

3. 发明公开

EP4040159A1 REAGENT MANAGEMENT METHOD 审中-实审
公开(公告)号：EP4040159A1
公开(公告)日：2022-08-10
申请号：EP20872485.6
申请日：2020-09-24
申请人： Sekisui Medical Co., Ltd.
发明人： KAWABE, Toshiki , OGASAWARA, Kosuke , IIJIMA, Yumi
IPC分类号： G01N35/00 , G01N35/02
摘要： Provided are an automatic analysis apparatus capable of sharing a reagent between a plurality of independent apparatuses and a method for sharing a reagent between apparatuses.
Independent automatic analysis apparatuses 1A and 1B of the invention include controllers 82A and 82B for controlling an operation of each unit of the apparatus, reagent-related information input/output units 81A and 81B for inputting and outputting reagent-related information I related to a reagent installed in a reagent supply portion including a reagent in use, reagent vessel detection units 83A and 83B for detecting that a reagent vessel is taken in and/or taken out of the automatic analysis apparatus, and reagent-related information reading units 84A and 84B for reading reagent-related information C from the reagent and/or reagent vessel in use detected to be taken in by the reagent vessel detection unit. The controllers 82A and 82B compare the reagent-related information C read by the reagent-related information reading unit 84A and 84B with the reagent-related information I input to the reagent-related information input/output units 81A and 81B, and control an operation of the reagent supply portion based on a comparison result thereof.

4. 发明公开

EP3988933A1 APTT PROLONGATION FACTOR ESTIMATION SYSTEM 审中-实审
公开(公告)号：EP3988933A1
公开(公告)日：2022-04-27
申请号：EP20827280.7
申请日：2020-06-19
申请人： Sekisui Medical Co., Ltd. , Public University Corporation Nara Medical University
发明人： KAWABE, Toshiki , ODA, Yukio , SHIMA, Midori , NOGAMI, Keiji , OGIWARA, Kenichi , SHIMONISHI, Naruto
IPC分类号： G01N33/48 , G01N33/86 , G06N20/00
摘要： Provided is an APTT prolongation factor estimation system. The APTT prolongation factor estimation system includes: one or more facilities each including an analyzer which measures a blood coagulation reaction of a subject blood specimen; a database which stores data on a blood coagulation reaction and APTT prolongation factor of blood specimens; and a computer which estimates an APTT prolongation factor of the subject blood specimen based on data on the blood coagulation reaction from the analyzer and the data stored in the database. The facilities each further includes: a data transmission unit which transmits, to the computer, the data on the blood coagulation reaction of the subject blood specimen obtained by the analyzer; and a data reception unit which receives a result of the estimation of the APTT prolongation factor, which is obtained by the computer, regarding the subject blood specimen measured by each of the analyzers.

5. 发明公开

EP4394386A1 AUTOMATIC ANALYSIS DEVICE AND REAGENT AMOUNT DISPLAY METHOD 审中-公开
公开(公告)号：EP4394386A1
公开(公告)日：2024-07-03
申请号：EP22904163.7
申请日：2022-12-02
申请人： Sekisui Medical Co., Ltd.
发明人： KAWABE, Toshiki , IIJIMA, Yumi , OGASAWARA, Kosuke
IPC分类号： G01N35/00
CPC分类号： G01N35/00
摘要： Provided are an automatic analysis device and a reagent amount display method capable of setting an appropriate amount of reagent at all times regardless of a skill level of an operator.
The automatic analysis device of the invention includes a history information storage unit 80 configured to store history information related to a previously conducted analysis, a number-of-analyses calculation unit 81 configured to calculate a number of analyses per unit, which is a number of analyses per day on each analysis day, for each analysis item from the history information, a classification/storage unit 82 configured to classify and store the number of analyses per unit by day of the week, a reagent remaining amount detection unit 83 configured to detect a reagent remaining amount, a conversion unit 84 configured to read each number of analyses per unit over a predetermined period corresponding to a day of a week of an analysis implementation date from the classification/storage unit 82 and convert the read each number of analyses per unit into a reagent usage amount with regard to each reagent used for the analysis for each analysis item, and a display device 192 configured to arrange and display information associated with the reagent usage amount and the reagent remaining amount for each reagent.

6. 发明公开

EP3919913A1 METHOD FOR ANALYZING BLOOD COAGULATION CHARACTERISTICS OF BLOOD SPECIMEN 审中-实审
公开(公告)号：EP3919913A1
公开(公告)日：2021-12-08
申请号：EP20749235.6
申请日：2020-01-31
申请人： Sekisui Medical Co., Ltd. , Public University Corporation Nara Medical University
发明人： KAWABE, Toshiki , ODA, Yukio , SHIMA, Midori , NOGAMI, Keiji , OGIWARA, Kenichi
IPC分类号： G01N33/86
摘要： To provide a method for analyzing coagulation characteristics of a blood specimen. To provide a method for analyzing a blood specimen, including: acquiring a waveform related to a coagulation rate or coagulation acceleration of a sample obtained by mixing a subject blood specimen with a reagent for measuring coagulation time; extracting multiple parameters characterizing the waveform related to a coagulation rate or a coagulation acceleration; and determining an activity level or activity abnormality of a coagulation factor in the subject blood specimen on the basis of the multiple parameters.

7. 发明公开

EP3882628A1 ANALYSIS METHOD, ANALYSIS DEVICE, AND ANALYSIS PROGRAM 审中-公开
公开(公告)号：EP3882628A1
公开(公告)日：2021-09-22
申请号：EP19883974.8
申请日：2019-11-15
申请人： Sekisui Medical Co., Ltd.
发明人： KAWABE, Toshiki , ODA, Yukio
IPC分类号： G01N33/49 , G01N33/86
摘要： Excellent analysis of a coagulation characteristic of a blood sample is implemented. A method for analyzing a coagulation characteristic of a blood specimen according to the present invention includes: acquiring data for a coagulation reaction curve indicating a coagulation reaction amount of a mixed solution containing a blood sample and a reagent with respect to reaction time; calculating data for a differential curve obtained by differentiating the coagulation reaction curve; calculating information related to a center-of-gravity point of the differential curve; and evaluating the coagulation characteristic of the blood sample using the information related to the center-of-gravity point.

8. 发明公开

EP3872497A1 AUTOSAMPLER, AUTOMATIC ANALYSIS DEVICE, SAMPLING METHOD, AND AUTOMATIC INSPECTION METHOD 审中-实审
公开(公告)号：EP3872497A1
公开(公告)日：2021-09-01
申请号：EP19874978.0
申请日：2019-10-21
申请人： Sekisui Medical Co., Ltd.
发明人： KAWABE, Toshiki
IPC分类号： G01N35/04
摘要： Provided is a small and high-performance autosampler.
Included are an installation part allowing a plurality of racks to be installed therein, an installation part movement mechanism which can move the installation part back and forth in a predetermined installation part transport direction and successively transfers the plurality of racks to a transport position 12, and a rack movement mechanism which can move the racks at the transport position back and forth in a predetermined rack transport direction, moves the racks forward in the rack transport direction to send out the racks, and moves the racks backward to send the racks back to the installation part after specimens are sampled from the specimen containers held in the racks, in which the racks are transferred to the transport position 12 by moving the installation part forward or backward as necessary, information about inspection item content is accumulated using the installation part as a unit, and an accumulation result is compared with the amount of measurement resources, so that sampling is started after it is determined that the measurement resources are not insufficient.

9. 发明公开

EP4303586A1 METHOD FOR ESTIMATING FACTOR OF PROLONGED COAGULATION TIME 审中-实审
公开(公告)号：EP4303586A1
公开(公告)日：2024-01-10
申请号：EP22763431.8
申请日：2022-03-04
申请人： Sekisui Medical Co., Ltd.
发明人： KAWABE, Toshiki , ODA, Yukio
IPC分类号： G01N33/86
摘要： A method for estimating a cause of coagulation time prolongation includes 1) detecting a coagulation reaction end point Pe in a coagulation reaction curve of a subject blood specimen having a prolonged coagulation time; 2) calculating T(X), wherein T(X) represents a measurement point or time at which the coagulation reaction curve reaches X% of Pe, and X is a variable of greater than 0 and equal to or less than 100; and 3) estimating a cause of coagulation time prolongation of the subject blood specimen based on a form of T(X).

10. 发明公开

EP3961211A1 METHOD FOR MEASURING TITER OF COAGULATION FACTOR INHIBITOR 审中-实审
公开(公告)号：EP3961211A1
公开(公告)日：2022-03-02
申请号：EP20795805.9
申请日：2020-04-23
申请人： Sekisui Medical Co., Ltd. , Public University Corporation Nara Medical University
发明人： KAWABE, Toshiki , ODA, Yukio , EMMI, Mari , SHIMA, Midori , NOGAMI, Keiji , OGIWARA, Kenichi , SHIMONISHI, Naruto
IPC分类号： G01N33/48 , G01N33/86
摘要： Provided is a method by which a titer of a coagulation factor inhibitor can be measured simply and in a short time. The present invention relates to a method for measuring a titer of a coagulation factor inhibitor. The method includes: preparing a mixed specimen containing a subject blood specimen and a normal blood specimen; heating the mixed specimen and acquiring a coagulation reaction curve for the heated mixed specimen; acquiring a coagulation reaction curve for the mixed specimen that has not been heated; calculating a parameter related to the coagulation reaction curve of the mixed specimen that has not been heated as a first parameter; calculating a parameter related to the coagulation reaction curve of the heated mixed specimen as a second parameter; and calculating a titer of a coagulation factor inhibitor in the subject blood specimen on the basis of the ratio or the difference between the first parameter and the second parameter.

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