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1. 发明授权

EP1713779B1 INDAZOLDERIVATE ALS INHIBITOREN DER HORMON-SENSITIVEN LIPASE 有权
标题翻译：吲唑，激素敏感脂肪酶的抑制剂
公开(公告)号：EP1713779B1
公开(公告)日：2011-04-13
申请号：EP05700954.0
申请日：2005-01-15
申请人： Sanofi-Aventis Deutschland GmbH
发明人： ZOLLER, Gerhard , PETRY, Stefan , MÜLLER, Günter , HEUER, Hubert , BARINGHAUS, Karl-Heinz
IPC分类号： C07D231/56 , A61K31/416 , A61P3/10
CPC分类号： C07D413/12 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The invention relates to indazole derivatives of general formula (I) or (II), with the meanings as given in the description, the pharmaceutically-acceptable salts and use thereof as medicaments.

2. 发明授权

EP1828107B1 HYDROXYBIPHENYL-CARBONSÄUREN UND DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权
标题翻译：羟基联苯碳酸及其衍生物，用于生产及其用途
公开(公告)号：EP1828107B1
公开(公告)日：2011-09-28
申请号：EP05817600.9
申请日：2005-12-02
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MÜLLER, Günter
IPC分类号： C07C233/87 , C07C233/63 , C07C233/47 , C07C233/51 , C07C235/52 , C07D317/68 , C07D307/68 , A61K31/195 , A61K31/36 , A61K31/341 , A61P3/10
CPC分类号： C07C233/51 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C2601/02 , C07C2601/14 , C07D307/68 , C07D317/68
摘要： The invention relates to substituted hydroxybiphenyls, the derivatives and the physiologically acceptable salts thereof. The invention relates to the compounds of formula (I), wherein the substituents R1, R2 and A are defined as indicated, and to the physiologically acceptable salts thereof. The inventive compounds are suitable e.g. as hypoglycemic drugs and as drugs for use in the prevention and treatment of diabetes.

3. 发明授权

EP1587806B1 PYRIMIDO 5,4-e 1,2,4 TRIAZIN-5,7-DIONE, VERF AHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权
标题翻译：嘧啶5,4-E 1,2,4-三嗪-5,7-二酮，VERF年，他们的生产和及其用途
公开(公告)号：EP1587806B1
公开(公告)日：2008-11-12
申请号：EP04700447.8
申请日：2004-01-07
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MUELLER, Guenter
IPC分类号： C07D487/04 , A61K31/53
CPC分类号： C07D487/04
摘要： The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diones and their physiologically acceptable salts and physiologically functional derivatives. The invention relates therefore to the compounds of formula (I) wherein the residues are defined as indicated, to the physiologically salts thereof and to methods for producing the same. The inventive compounds are suited for use, for example, as antidiabetic agents.

4. 发明公开

EP1651644A1 SUBSTITUIERTE THIAZOL-BENZOISOTHIAZOLDIOXIDDERIVATIVE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权
标题翻译： SUBSTITUIERTE THIAZOL-BENZOISOTHIAZOLDIOXIDorderIVATIVE，VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG
公开(公告)号：EP1651644A1
公开(公告)日：2006-05-03
申请号：EP04741034.5
申请日：2004-07-15
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MUELLER, Guenter
IPC分类号： C07D417/12 , C07D417/14 , A61K31/426 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14
摘要： The invention relates to compounds of formula (I) wherein the radicals have the cited designations, and to the physiologically compatible salts thereof. Said compounds are suitable, for example, as medicaments for reducing blood sugar levels and for the prevention and treatment of diabetes.
摘要翻译：本发明涉及式（I）的化合物及其生理上相容的盐，其中基团具有所引用的名称。所述化合物适合于例如作为降低血糖水平和预防和治疗糖尿病的药物。

5. 发明公开

EP1771426A1 DIPHENYLAMINSUBSTITUIERTE SALICYLTHIAZOLDERIVATE UND VERWANDTE VERBINDUNGEN ALS PHOSPHOTYROSINPHOSPHATASE 1B (PTP1B) HEMMER ZUR VERWENDUNG ALS BLUTZUCKERSENKENDE WIRKSTOFFE ZUR BEHANDLUNG VON DIABETES 有权
标题翻译：二苯基卟啉盐酸盐水杨酸盐戊二酸盐VERBANDUNGEN ALS磷酸酪氨酸磷酸酶1B（PTP1B）HEMMER ZUR VERWENDUNG ALS BLUTZUCKERSENKENDE WIRKSTOFFE ZUR BEHANDLUNG VON DIABETES
公开(公告)号：EP1771426A1
公开(公告)日：2007-04-11
申请号：EP05756578.0
申请日：2005-07-02
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MUELLER, Guenter , KIRSCH, Reinhard
IPC分类号： C07D277/42 , C07D277/46 , A61K31/426 , A61P3/10
CPC分类号： C07D277/42 , C07D277/46
摘要： The aim of the invention is to provide compounds having a therapeutic blood-sugar decreasing effect. Said compounds are suitable especially for the prevention and treatment of pancreatic diabetes. To this end, the invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 independently represent H, F, Cl, Br, J, OH, CF3, NO2, CN, OCF3, O-(C1-C6)-alkyl, O-(C1-C4)-alkoxy-(C1-C4)-alkyl, S-(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O-(C3-C8)-cycloalkyl, (C3-C8)-cycloalkenyl, O-(C3-C8)-cycloalkenyl, (C2-C6)-alkinyl, aryl, O-aryl, (C1-C8)alkylene-aryl, O-(C1-C8)-alkylene-aryl, S-aryl, CO-NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH-SO2-CH3, SO2-CH3, COOH, COO-(C1-C6)-alkyl, or CO-N((C1-C6)-alkyl)2; R6 represents H, (C1-C6)-alkyl; A represents a bond, -CH2-, -NH-, -CH2-O-, -S-, -CH2-CH2-, or -CH(CH3)-; B represents NH, NH(C1-C4)-alkyl, or NH(CO); and D represents phenyl or a heterocycle. The invention also relates to the physiologically compatible salts of said compounds.
摘要翻译：本发明的目的是提供具有治疗性血糖降低作用的化合物。所述化合物特别适用于预防和治疗胰腺糖尿病。为此，本发明涉及式（I）的化合物，其中R 1，R 2，R 3，R 4，R 5独立地代表H，F，Cl，Br，J，OH，CF 3，NO 2，CN，OCF 3，O- （C 1 -C 4） - 烷基，O-（C 1 -C 4） - 烷氧基 - （C 1 -C 4） - 烷基，S-（C 1 -C 6） - 烷基，（C 3 -C 8）环烷基，O-（C 3 -C 8）环烷基，（C 3 -C 8）环烯基，O-（C 3 -C 8）环烯基，（C 1 -C 8）亚烷基 - 芳基，O-（C 1 -C 8） - 亚烷基 - 芳基，S-芳基，CO-NH（C 1 -C 6） - 烷基，N SO2-CH3，SO2-CH3，COOH，COO-（C1-C6）烷基或CO-N（（C1-C6）烷基）2; R6代表H，（C1-C6） - 烷基; A表示键，-CH 2 - ， - NH - ， - CH 2 -O - ， - S - ， - CH 2 -CH 2 - 或-CH（CH 3） - ; B代表NH，NH（C 1 -C 4） - 烷基或NH（CO）; D代表苯基或杂环。本发明还涉及所述化合物的生理相容性盐。

6. 发明授权

EP1771426B1 DIPHENYLAMINSUBSTITUIERTE SALICYLTHIAZOLDERIVATE UND VERWANDTE VERBINDUNGEN ALS PHOSPHOTYROSINPHOSPHATASE 1B (PTP1B) HEMMER ZUR VERWENDUNG ALS BLUTZUCKERSENKENDE WIRKSTOFFE ZUR BEHANDLUNG VON DIABETES 有权
标题翻译： DIPHENYLAMINSUBSTITUIERTE SALICYLTHIAZOLDERIVATE及相关化合物AS磷酸酪氨酸磷酸酶1B（PTP1B）抑制剂FOR USE AS血糖降低物质对于糖尿病的治疗
公开(公告)号：EP1771426B1
公开(公告)日：2007-12-19
申请号：EP05756578.0
申请日：2005-07-02
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MUELLER, Guenter , KIRSCH, Reinhard
IPC分类号： C07D277/42 , C07D277/46 , A61K31/426 , A61P3/10
CPC分类号： C07D277/42 , C07D277/46
摘要： The aim of the invention is to provide compounds having a therapeutic blood-sugar decreasing effect. Said compounds are suitable especially for the prevention and treatment of pancreatic diabetes. To this end, the invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 independently represent H, F, Cl, Br, J, OH, CF3, NO2, CN, OCF3, O-(C1-C6)-alkyl, O-(C1-C4)-alkoxy-(C1-C4)-alkyl, S-(C1-C6)-alkyl, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C3-C8)-cycloalkyl, O-(C3-C8)-cycloalkyl, (C3-C8)-cycloalkenyl, O-(C3-C8)-cycloalkenyl, (C2-C6)-alkinyl, aryl, O-aryl, (C1-C8)alkylene-aryl, O-(C1-C8)-alkylene-aryl, S-aryl, CO-NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH-SO2-CH3, SO2-CH3, COOH, COO-(C1-C6)-alkyl, or CO-N((C1-C6)-alkyl)2; R6 represents H, (C1-C6)-alkyl; A represents a bond, -CH2-, -NH-, -CH2-O-, -S-, -CH2-CH2-, or -CH(CH3)-; B represents NH, NH(C1-C4)-alkyl, or NH(CO); and D represents phenyl or a heterocycle. The invention also relates to the physiologically compatible salts of said compounds.

7. 发明公开

EP1828107A1 HYDROXYBIPHENYL-CARBONSÄUREN UND DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权
标题翻译：羟基苯乙烯碳氢化合物，VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG
公开(公告)号：EP1828107A1
公开(公告)日：2007-09-05
申请号：EP05817600.9
申请日：2005-12-02
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MÜLLER, Günter
IPC分类号： C07C233/87 , C07C233/63 , C07C233/47 , C07C233/51 , C07C235/52 , C07D317/68 , C07D307/68 , A61K31/195 , A61K31/36 , A61K31/341 , A61P3/10
CPC分类号： C07C233/51 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C2601/02 , C07C2601/14 , C07D307/68 , C07D317/68
摘要： The invention relates to substituted hydroxybiphenyls, the derivatives and the physiologically acceptable salts thereof. The invention relates to the compounds of formula (I), wherein the substituents R1, R2 and A are defined as indicated, and to the physiologically acceptable salts thereof. The inventive compounds are suitable e.g. as hypoglycemic drugs and as drugs for use in the prevention and treatment of diabetes.
摘要翻译：公开了本文定义的式I的新化合物及其作为用于降低血糖的药物活性化合物和/或治疗II型糖尿病，脂质和碳水化合物代谢紊乱，动脉硬化表现和胰岛素抵抗的一种或多种的用途。

8. 发明授权

EP1311264B1 SUBSTITUIERTE UND UNSUBSTITUIERTE BENZOOXATHIAZOLE SOWIE DARAUS ABGELEITETE VERBINDUNGEN 有权
标题翻译：取代和未取代BENZOOXATHIAZOLE和物品来源的化合物
公开(公告)号：EP1311264B1
公开(公告)日：2007-06-27
申请号：EP01969532.9
申请日：2001-07-27
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , HÖLDER, Swen , MUELLER, Guenter
IPC分类号： A61K31/425 , A61P3/10 , C07D291/08
CPC分类号： C07D285/14 , C07D291/08
摘要： The invention relates to substituted and non-substituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxide, 1,3-dihydro-benzo[1,2,5]thiadiazole 2,2-dioxide and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxide, in addition to the production and use thereof in pharmaceuticals.

9. 发明授权

EP1554259B1 NEUE BICYCLISCHE INHIBITOREN DER HORMON SENSITIVEN LIPASE 有权
标题翻译：新的双环激素敏感脂肪酶的抑制剂
公开(公告)号：EP1554259B1
公开(公告)日：2006-12-27
申请号：EP03808700.3
申请日：2003-09-27
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MUELLER, Guenter , HEUER, Hubert
IPC分类号： C07D249/18 , C07D401/06 , C07D403/06 , A61K31/4192 , A61P3/10
CPC分类号： C07D401/06 , C07D249/18 , C07D403/06 , C07D471/10
摘要： The invention relates to benzotriazoles of general formula (I), wherein R1 - R8 have the above mentioned meanings. The invention also relates to a method for the production thereof. Said compounds have an inhibiting effect on the hormone sensitive lipase.

10. 发明授权

EP1651644B1 SUBSTITUIERTE THIAZOL-BENZOISOTHIAZOLDIOXIDDERIVATIVE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权
标题翻译：取代噻唑BENZOISOTHIAZOLDIOXIDDERIVATIVE，用于生产及其用途
公开(公告)号：EP1651644B1
公开(公告)日：2006-11-22
申请号：EP04741034.5
申请日：2004-07-15
申请人： Sanofi-Aventis Deutschland GmbH
发明人： PETRY, Stefan , BARINGHAUS, Karl-Heinz , TENNAGELS, Norbert , MUELLER, Guenter
IPC分类号： C07D417/12 , C07D417/14 , A61K31/426 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14
摘要： The invention relates to compounds of formula (I) wherein the radicals have the cited designations, and to the physiologically compatible salts thereof. Said compounds are suitable, for example, as medicaments for reducing blood sugar levels and for the prevention and treatment of diabetes.

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