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1. 发明公开

EP0300062A1 NOVEL ANDROST-4-ENE-3,17-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效
标题翻译： NEER ANDROST-4-EN-3,17-DION-DERIVATE UND VERFAHREN ZUR HERSTELLUNG。
公开(公告)号：EP0300062A1
公开(公告)日：1989-01-25
申请号：EP88901462.7
申请日：1988-02-05
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： YOSHIHAMA, Makoto , TAMURA, Koji 2-D, Matsubara Manshon , MIYATA, Nobuo , NAKAYAMA, Shoji , NAKAKOSHI, Masamichi
IPC分类号： C07J1/00 , C12P33/06
CPC分类号： C07J1/0011 , C12P33/06
摘要： Compounds of formula (1),
H(α)OR(β), Y represents H 2 or OH(∇)H(β), Z represents H or OH(α), and R represents H, COCH 3 , COCH 2 CH 3 , COCH(CH 3 ) 2 or COC(CH 3 ) 3 . which are prepared by bringing androst-4-ene-3,17-dione into contact with microorganisms belonging to the genus Acremonium. These compounds are effective in inhibiting estrogen synthetase of human placenta origin.
摘要翻译：式（I）的雄甾-4-烯-3,17-二酮是新的; 其中X为= O或β-OR; Y是H或OH; Z是H或OH; R为H，乙酰基，丙酰基，异丁酰基或新戊酰基。县。 14α-羟基雄甾-4-烯-3,6,17-三酮; 6β，11α-二羟基雄甾-4-端-3,17-二酮; 6βeta，14α-二羟基雄甾-4-烯-3,17-二酮; 6β-乙酰氧基-14α-羟基雄甾-4-烯-3,17-二酮; 14α-羟基-6β-丙酰氧基雄甾-4-烯-3,17-二酮; 14α-羟基-6β-异丁酰氧基雄甾-4-端-3,17-二酮和14α-羟基-6β新戊酰氧基雄甾-4-烯-3,17-二酮。制备方法。包括在雄甾-4-烯-3,17-二酮存在下培养顶孢菌种（特别是A.strictum NN-106; FERM P-9143），得到（I，X =β-OH），其可被氧化成（ I，X = = O）或酰化（例如用酸酐）。

2. 发明公开

EP0902022A1 NOVEL BENZOFURANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译： BENZOFURANON-DERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP0902022A1
公开(公告)日：1999-03-17
申请号：EP98900226.6
申请日：1998-01-13
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： YOSHIHAMA, Makoto , NAKAKOSHI, Masamichi , NAKAMURA, Junji , NAKAYAMA, Shoji
IPC分类号： C07D307/83 , C07D407/06 , C07D405/06 , A61K31/34 , A61K31/40
CPC分类号： C07D405/06 , C07D307/83 , C07D407/06
摘要： The present invention provides new benzofuranone derivatives and a method for producing the derivatives useful for a therapeutic agent for preventing and/or treating hormone dependent diseases.
The present invention is a new benzofuranone derivative represented by a particular general formula (I).

In the production, a particular benzofuranone compound and a particular benzaldehyde are reacted.
摘要翻译：本发明提供新的苯并呋喃酮衍生物和用于制备用于预防和/或治疗激素依赖性疾病的治疗剂的衍生物的方法。本发明是由特定的通式（I）表示的新的苯并呋喃酮衍生物。在生产中，特定的苯并呋喃酮化合物和特定的苯甲醛反应。

3. 发明公开

EP0553357A1 NOVEL PROLYL ENDOPEPTIDASE INHIBITORS SNA-115 AND SNA-115T, PRODUCTION THEREOF, AND STRAIN WHICH PRODUCES SAID INHIBITORS 失效
标题翻译：新型prolylendopeptidase抑制剂SNA 115和SNA 115T，生产，和做二手部落。
公开(公告)号：EP0553357A1
公开(公告)日：1993-08-04
申请号：EP92912434.5
申请日：1992-06-19
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： KIMURA, Kenichi , KANOU, Fumiko , TAKAHASHI, Hidetoshi, Nishiura Haitsu 2-1 , KUROSAWA, Kazuhiko, Nishiura Haitsu 1-3 , YOSHIHAMA, Makoto
IPC分类号： C07K7/54 , C07K7/02 , C12P21/04 , C12P21/06 , C12N1/20
CPC分类号： C07K7/56 , A61K38/00
摘要： A prolyl endopeptidase inhibitor SNA-115, which is a peptide represented by C₁₁₃H₁₄₂N₂₆O₂₇. An SNA-115 producing bacterium belonging to Microbispora sp. A process for producing SNA-115 by culturing the SNA-115 producing bacterium. A prolyl endopeptidase inhibitor SNA-115T, which is a peptide represented by C₁₁₃H₁₄₄N₂₆O₂₈ and produced by hydrolyzing SNA-115 with trypsin. SNA-115 and SNA-115T have a prolyl endopeptidase inhibiting activity and are useful as an active ingredient for preventing and treating amnesia, acquired immunodeficiency syndrome (AIDS) and HIV diseases.
摘要翻译：脯氨酰内肽酶抑制剂SNA-115，所有这些是C113H142N26O27代表的肽。一个SNA 115产生细菌属于菌属SP。一种用于通过培养SNA-115生产菌生产SNA 115的过程。脯氨酰内肽酶抑制剂SNA-115T，所有这一切是通过C113H144N26O28表示并且通过用胰蛋白酶水解SNA-115产生的肽。 SNA-115和SNA-115T具有脯氨酰内肽酶抑制活性，并且作为用于预防和治疗健忘症，获得性免疫缺陷综合征（AIDS）和HIV疾病的活性成分是有用的。

4. 发明公开

EP0902003A1 NOVEL TETRALONE OR BENZOPYRANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译： NEE TERRALON-ODER BENZOPYRANON-DERIVATE UND EIN VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP0902003A1
公开(公告)日：1999-03-17
申请号：EP98901023.6
申请日：1998-01-28
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： YOSHIHAMA, Makoto , NAKAKOSHI, Masamichi , NAKAMURA, Junji , NAKAYAMA, Shoji
IPC分类号： C07C49/643 , C07C49/697 , C07C49/747 , C07C49/755 , C07C45/74 , C07C225/22 , C07D311/22 , A61K31/12 , A61K31/135 , A61K31/35
CPC分类号： C07D407/06 , C07C45/74 , C07C49/747 , C07C49/755 , C07C65/40 , C07C225/22 , C07C2602/10 , C07D311/22 , C07D317/54 , C07D319/18
摘要： The present invention provides new tetralone or benzopyranone derivatives and a method for producing the derivatives useful for a therapeutic agent for preventing and/or treating hormone dependent diseases.
The present invention is a new tetralone or benzopyranone derivative represented by a particular general formula (I).
wherein R 1 and R 2 represent hydrogen, a hydroxy group, an alkyloxy group or an aralkyloxy group, respectively, R 3 - R 7 represent hydrogen, a hydroxy group or a straight or branched alkyl, alkyloxy or aralkyloxy group having 1-6 carbon atoms, a halogen, an amino group or an alkylene dioxy group joined at R 3 and R 4 , R 4 and R 5 , R 5 and R 6 , or R 6 and R 7 , respectively, and A represents a methylene or oxygen.
In the production, a particular tetralone or benzopyranone compound and a particular benzaldehyde compound are reacted.
摘要翻译：本发明提供了新的四氢萘酮或苯并吡喃酮衍生物和用于制备用于预防和/或治疗激素依赖性疾病的治疗剂的衍生物的方法。本发明是由特定通式（I）表示的新的四氢萘酮或苯并吡喃酮衍生物。其中R 1和R 2分别表示氢，羟基，烷氧基或芳烷氧基，R 3 -R 7表示氢，羟基或具有1-6个碳原子的直链或支链烷基，烷氧基或芳烷氧基，分别在R3和R4，R4和R5，R5和R6或R6和R7连接的卤素，氨基或亚烷基二氧基，A表示亚甲基或氧。在生产中，特定的四氢萘酮或苯并吡喃酮化合物和特定的苯甲醛化合物反应。

5. 发明公开

EP0683237A1 METHOD OF EXAMINING HORMONE-DEPENDENT TUMOR 失效
标题翻译： VERFAHREN ZUR UNTERSUCHUNG VONHORMONABHÄNGIGENTUMOREN。
公开(公告)号：EP0683237A1
公开(公告)日：1995-11-22
申请号：EP94914618.7
申请日：1994-05-13
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： NAKAMURA, Junji, Nishiura Haitsu 2-4 , YOSHIHAMA, Makoto
IPC分类号： C12Q1/25
CPC分类号： G01N33/57407 , C12Q1/25 , G01N33/743
摘要： A method of examining hormone-dependent tumors which comprises culturing tumor tissues in each of (a) a medium, (b) a medium containing a hormone synthetase substrate, and (c) a medium containing both a hormone synthetase substrate and a hormone synthetase inhibitor, measuring the growth rate of tumor cells in each medium, determining (i) the ratio of the growth rate of tumor cells in the presence of a hormone synthetase substrate to that in a medium alone and (ii) the ratio of the growth rate of tumor cells in the presence of both a hormone synthetase substrate and a hormone synthetase inhibitor to that in a medium alone. This method enables judging whether there are any hormone synthetase and hormone-dependent growth of hormone-dependent tumors readily at the same time. Further it can be employed for developing a new method of classifying tumors and selecting a guide line for tumor therapy.
摘要翻译：一种检查激素依赖性肿瘤的方法，其包括在（a）培养基，（b）含有激素合成酶底物的培养基中培养肿瘤组织，和（c）含有激素合成酶底物和激素合成酶抑制剂的培养基测量每个培养基中肿瘤细胞的生长速率，确定（i）在激素合成酶底物存在下肿瘤细胞生长速率与单独培养基中肿瘤细胞的生长速率的比率，以及（ii）在激素合成酶底物和激素合成酶抑制剂存在的情况下，肿瘤细胞与单独的培养基相同。该方法能够同时判断激素依赖性肿瘤是否具有激素合成酶和激素依赖性生长。此外，它可以用于开发一种新的肿瘤分类方法和选择肿瘤治疗的指导线。

6. 发明授权

EP0301102B1 NOVEL 7$g(b)-HYDROXY-4-PREGNENE-3,20-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效
标题翻译：新型7-G（B） - 羟基-4-丙氨酸-3,20-二酮衍生物及其制备方法
公开(公告)号：EP0301102B1
公开(公告)日：1991-11-06
申请号：EP88901463.5
申请日：1988-02-05
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： YOSHIHAMA, Makoto , TAMURA, Koji 2-D, Matsubara Manshon , MIYATA, Nobuo , NAKAKOSHI, Masamichi
IPC分类号： C07J7/00 , C12P33/12
CPC分类号： C12P33/06 , C07J7/002 , C07J7/0045
摘要： Compounds of formula (I), wherein X represents =O or H(alpha)OH(beta), and Y represents H(alpha) or OH(alpha), which are prepared by bringing 4-pregnene-3,20-dione into contact with microorganisms belonging to the genus Acremonium. These compounds possess an activity of inducing cell differentiation.

7. 发明公开

EP0301102A1 NOVEL 7$g(b)-HYDROXY-4-PREGNENE-3,20-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效
标题翻译： NEER 7-g（b）-HYDROXY-4-PREGNEN-3,20-DION-DERIVATE UND VERFAHREN ZUR HERSTELLUNG。
公开(公告)号：EP0301102A1
公开(公告)日：1989-02-01
申请号：EP88901463.5
申请日：1988-02-05
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： YOSHIHAMA, Makoto , TAMURA, Koji 2-D, Matsubara Manshon , MIYATA, Nobuo , NAKAKOSHI, Masamichi
IPC分类号： C07J7/00 , C12P33/12
CPC分类号： C12P33/06 , C07J7/002 , C07J7/0045
摘要： Compounds of formula (1), wherein X represents = O or H(α)OH((β), and Y represents H(a) or OH(α), which are prepared by bringing 4-pregnene-3,20-dione into contact with microorganisms belonging to the genus Acremonium These compounds posses an activity of inducing cell differentiation.
摘要翻译： 7-β-羟基孕-4-烯-3,20-二酮（I）是新的; 其中X为= O或β-OH; Y是H或OH。制备方法。包括在怀孕-4-烯-3,20-二酮存在下的顶孢菌种（esp.Astrictum，FERM P-9143）的培养物。县。 7beta，15beta，17α-三羟基孕-4-烯-3,20-二酮; 7β-羟基孕-4-烯-3,15,20-三酮。

8. 发明公开

EP1001035A1 NOVEL ANTIBIOTICS RK-1061 AND PROCESS FOR PREPARING THE SAME 失效
标题翻译： ANTIBIOTIKA RK-1061 UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP1001035A1
公开(公告)日：2000-05-17
申请号：EP97919709.2
申请日：1997-04-25
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： KIMURA, Ken-ichi , IKEDA, Yoshikazu , KAGAMI, Shinobu, Matsubara mansion 2A , TAKAHASHI, Hidetoshi , TAKAHASHI, Kousaku , YOSHIHAMA, Makoto , UBUKATA, Makoto , ISONO, Kiyoshi
IPC分类号： C12P17/16 , C12N1/20 , C07H19/06 , A61K31/70
CPC分类号： C07H19/06 , C12P19/385
摘要： Antibiotics RK-1061s having a novel chemical structure and a method of production thereof.
They have a structural formula represented by general formula (I) wherein A represents R 1 or R 1 CH (OR 2 ) CH 2 . R 2 represents 3-methylglutaric acid residue and R 3 represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061s from the culture. Streptomyces sp. SN-1061Ms (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.
摘要翻译：具有新化学结构的抗生素RK-1061及其生产方法。它们具有由通式（I）表示的结构式，其中A表示R 1或R 1CH（OR 2）CH 2。 R2表示3-甲基戊二酸残基，R 3表示硫酸基或氢原子。该方法包括培养属于链霉菌属的射线真菌，并从培养物中分离RK-1061。链霉菌属 SN-1061Ms（FERM BP-5800）能够以高生产率稳定地生产RK-1061。

9. 发明授权

EP0553357B1 NOVEL PROLYL ENDOPEPTIDASE INHIBITORS SNA-115 AND SNA-115T, PRODUCTION THEREOF, AND STRAIN WHICH PRODUCES SAID INHIBITORS 失效
标题翻译：新型prolylendopeptidase抑制剂SNA 115和SNA 115T，生产，做使用的菌株
公开(公告)号：EP0553357B1
公开(公告)日：1997-09-10
申请号：EP92912434.5
申请日：1992-06-19
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： KIMURA, Kenichi , KANOU, Fumiko , TAKAHASHI, Hidetoshi, Nishiura Haitsu 2-1 , KUROSAWA, Kazuhiko, Nishiura Haitsu 1-3 , YOSHIHAMA, Makoto
IPC分类号： C07K7/54 , C07K7/02 , C12P21/04 , C12P21/06 , C12N1/20
CPC分类号： C07K7/56 , A61K38/00
摘要： A prolyl endopeptidase inhibitor SNA-115, which is a peptide represented by C113H142N26O27. An SNA-115 producing bacterium belonging to Microbispora sp. A process for producing SNA-115 by culturing the SNA-115 producing bacterium. A prolyl endopeptidase inhibitor SNA-115T, which is a peptide represented by C113H144N26O28 and produced by hydrolyzing SNA-115 with trypsin. SNA-115 and SNA-115T have a prolyl endopeptidase inhibiting activity and are useful as an active ingredient for preventing and treating amnesia, acquired immunodeficiency syndrome (AIDS) and HIV diseases.

10. 发明授权

EP0300062B1 NOVEL ANDROST-4-ENE-3,17-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效
标题翻译：新型安慰剂4-ENE-3,17二酮衍生物及其制备方法
公开(公告)号：EP0300062B1
公开(公告)日：1992-07-29
申请号：EP88901462.7
申请日：1988-02-05
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： YOSHIHAMA, Makoto , TAMURA, Koji 2-D, Matsubara Manshon , MIYATA, Nobuo , NAKAYAMA, Shoji , NAKAKOSHI, Masamichi
IPC分类号： C07J1/00 , C12P33/06
CPC分类号： C07J1/0011 , C12P33/06
摘要： Compounds of formula (I), wherein X represents =O or H(alpha)OR(beta), Y represents H2 or OH(alpha)H(beta), Z represents H or OH(alpha), and R represents H, COCH3, COCH2CH3, COCH(CH3)2 or COC(CH3)3, which are prepared by bringing androst-4-ene-3,17-dione into contact with microorganisms belonging to the genus Acremonium. These compounds are effective in inhibiting estrogen synthetase of human placenta origin.

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