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1. 发明公开

EP2415756A4 ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY 审中-公开
标题翻译：异硫脲或与异脲衍生物BACE1锁效果
公开(公告)号：EP2415756A4
公开(公告)日：2012-08-29
申请号：EP10758619
申请日：2010-03-29
申请人： SHIONOGI & CO
发明人： TAMURA YUUSUKE , SUZUKI SHINJI , MATSUMOTO SAE , HORI AKIHIRO , KOORIYAMA YUUJI
IPC分类号： C07C275/28 , A61K31/44 , A61K31/4965 , A61K31/505 , A61P25/28 , A61P43/00 , C07C335/12 , C07C335/16 , C07C335/18 , C07D213/81 , C07D213/85 , C07D239/42 , C07D241/24 , C07D401/12 , C07D405/12
CPC分类号： C07D213/81 , C07C275/70 , C07C335/32 , C07D213/85 , C07D239/42 , C07D241/24 , C07D241/28 , C07D401/12 , C07D405/12 , C07D413/12

2. 发明公开

EP3187498A4 AZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING EFFECT 审中-公开
公开(公告)号：EP3187498A4
公开(公告)日：2018-01-17
申请号：EP15836882
申请日：2015-08-26
申请人： SHIONOGI & CO
发明人： TAMURA YUUSUKE , HINATA YU , KOJIMA EIICHI , OZASA HIROKI
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , C07D519/00
CPC分类号： A61K31/437 , A61K31/03 , A61K31/10 , A61K31/343 , A61K31/444 , A61K31/5377 , C07D471/04 , C07D519/00
摘要： Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or its pharmaceutically acceptable salt, wherein X is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; R 1 is hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkylsulfonyl, or substituted or unsubstituted alkyloxycarbonyl; R 2 is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like; R 3 is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like; and R 4 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the like.

3. 发明公开

EP2360155A4 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY 审中-公开
标题翻译： WITH BACE1锁定效果2-氨基吡啶-4-与2-氨基吡啶衍生物
公开(公告)号：EP2360155A4
公开(公告)日：2012-06-20
申请号：EP09822069
申请日：2009-10-22
申请人： SHIONOGI & CO
发明人： YONEZAWA SHUJI , TAMURA YUUSUKE , KOORIYAMA YUUJI , SAKAGUCHI GAKU
IPC分类号： C07D401/12 , A61K31/497 , A61K31/506 , A61P25/28 , A61P43/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04

4. 发明公开

EP2147914A4 AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUPS 有权
标题翻译：与环基团取代AMINODIHYDROTHIAZIN衍生物
公开(公告)号：EP2147914A4
公开(公告)日：2011-08-17
申请号：EP08751985
申请日：2008-04-23
申请人： SHIONOGI & CO
发明人： TAMURA YUUSUKE , SUZUKI SHINJI , TADA YUKIO , YONEZAWA SHUJI , FUJIKOSHI CHIAKI , MATSUMOTO SAE , KOORIYAMA YUUJI , UENO TATSUHIKO
IPC分类号： C07D279/06 , A61K31/497 , A61K31/54 , A61K31/541 , A61P25/28 , A61P43/00 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC分类号： C07C215/20 , A61K9/0019 , A61K9/1623 , A61K9/2018 , C07D279/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D513/04

5. 发明公开

EP2963013A4 INDOLE AND AZAINDOLE DERIVATIVES EACH HAVING AMPK-ACTIVATING ACTIVITY 审中-公开
标题翻译：吲哚和与每个AMPK活化作用氮杂吲哚衍生物
公开(公告)号：EP2963013A4
公开(公告)日：2016-09-14
申请号：EP14756889
申请日：2014-02-26
申请人： SHIONOGI & CO
发明人： TAMURA YUUSUKE , KOJIMA EIICHI , IKEMOTO HIDAKA , HINATA YU
IPC分类号： C07D209/42 , A61K31/4045 , A61K31/5377 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/50 , A61P7/00 , A61P9/12 , A61P43/00 , C07D405/12 , C07D471/04 , C07D493/04 , C07D519/00
CPC分类号： C07D209/34 , A61K31/4045 , A61K31/5377 , C07D209/42 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D493/04 , C07D519/00 , C07H17/02
摘要： Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or its pharmaceutically acceptable salt, wherein Y is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; T is -CR 7 = or -N=; U is -CR 8 = or -N=; R 2 is hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkylsulfonyl, or substituted or unsubstituted alkyloxycarbonyl; R 3 is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like; and R 4 , R 7 and R 8 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like.

6. 发明公开

EP2703392A4 5-MEMBERED RING AROMATIC HETEROCYCLIC DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY 有权
标题翻译：芳香族杂环衍生物均与NPY Y5受体拮抗剂-EFFECT的5元环的形式
公开(公告)号：EP2703392A4
公开(公告)日：2014-10-15
申请号：EP12777012
申请日：2012-04-25
申请人： SHIONOGI & CO
发明人： HAYASHI KYOHEI , TAMURA YUUSUKE , OMORI NAOKI
IPC分类号： C07D271/06 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , A61K31/4439 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P15/00 , A61P25/08 , A61P25/20 , A61P25/24 , A61P43/00 , C07D263/48 , C07D271/08
CPC分类号： C07D271/113 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D263/48 , C07D271/06 , C07D271/07 , C07D271/08 , C07D271/10 , C07D277/20 , C07D277/42 , C07D285/08 , C07D413/04

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