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1. 发明公开

EP0390574A2 Compositions of phytic acid, and pharmaceutical uses thereof 失效
标题翻译： PhytinsäurehaltigeMittel sowie deren pharmazeutische Verwendungen。
公开(公告)号：EP0390574A2
公开(公告)日：1990-10-03
申请号：EP90303397.5
申请日：1990-03-29
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Sawai, Kiichi, c/o Sanwa Kagaku , Kurono, Masayasu, c/o Sanwa Kagaku , Asai, Hiromoto, c/o Sanwa Kagaku , Mitani, Takahiko, c/o Sanwa Kagaku , Ninomiya, Naohisa, c/o Sanwa Kagaku
IPC分类号： A61K31/66 , A61K47/12
CPC分类号： A61K47/183 , A61K31/66 , A61K33/26 , A61K47/12 , A61K2300/00
摘要： An aqueous solution contains (a) phytic acid in amount of 1.00 mmol to 1.00 mol litre and (b) ferric ions to increase the phytic acid solubility,e.g. derived from a monobasic or polybasic acid (e.g. ferric citrate) and (c) carboxylic acid ions to hasten the dissolution and optionally (d) other additives to enhance the bioabsorption of (a) and (b), e.g. as (d) a carboxylic acid or salt, a saccharide, an amino acid or salt or an organic phosphoric acid or salt.
A suitable molar proportion of (a): (b): (c): (d)is 10:1:1:0 to 1:12:36:200.
The solution can be dried to a powder, and the solution or powder incorporated in solid or liquid pharmaceutical compositions.
The solutions or compositions are useful for the removal of uraroma or body smell or as an antidote to the effect of alcohol or drugs on the central nervous system, for the treatment of diabetes, hyperlipemia, hypohepatia, dysmesia or degeneration of erythrocytes, or to inhibit the proliferation of fat cells or reduce lipometabolism.
摘要翻译：水溶液含有（a）植酸，其量为1.00mmol至1.00mol /升，和（b）三价铁离子以增加植酸溶解度，例如，衍生自一元酸或多元酸（例如柠檬酸铁）和（c）羧酸离子以加速溶解和任选地（d）其它添加剂以增强（a）和（b），例如（b）的生物吸收。作为（d）羧酸或盐，糖类，氨基酸或盐或有机磷酸或盐。（a）：（b）：（c）：（d）的合适的摩尔比例为10:1:1:0:1:12:36:200。溶液可以干燥成粉末，并将溶液或粉末掺入固体或液体药物组合物中。溶液或组合物可用于去除尿潴留或身体气味，或作为解决酒精或药物对中枢神经系统的作用的解毒剂，用于治疗糖尿病，高脂血症，低血脂症，红斑或红细胞变性或抑制脂肪细胞的增殖或减少脂肪代谢。

2. 发明公开

EP0390574A3 Compositions of phytic acid, and pharmaceutical uses thereof 失效
标题翻译：植物酸的组合物及其药物用途
公开(公告)号：EP0390574A3
公开(公告)日：1991-07-17
申请号：EP90303397.5
申请日：1990-03-29
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： Sawai, Kiichi, c/o Sanwa Kagaku , Kurono, Masayasu, c/o Sanwa Kagaku , Asai, Hiromoto, c/o Sanwa Kagaku , Mitani, Takahiko, c/o Sanwa Kagaku , Ninomiya, Naohisa, c/o Sanwa Kagaku
IPC分类号： A61K31/66 , A61K47/12
CPC分类号： A61K47/183 , A61K31/66 , A61K33/26 , A61K47/12 , A61K2300/00
摘要： An aqueous solution contains (a) phytic acid in amount of 1.00 mmol to 1.00 mol litre and (b) ferric ions to increase the phytic acid solubility,e.g. derived from a monobasic or polybasic acid (e.g. ferric citrate) and (c) carboxylic acid ions to hasten the dissolution and optionally (d) other additives to enhance the bioabsorption of (a) and (b), e.g. as (d) a carboxylic acid or salt, a saccharide, an amino acid or salt or an organic phosphoric acid or salt. A suitable molar proportion of (a): (b): (c): (d)is 10:1:1:0 to 1:12:36:200. The solution can be dried to a powder, and the solution or powder incorporated in solid or liquid pharmaceutical compositions. The solutions or compositions are useful for the removal of uraroma or body smell or as an antidote to the effect of alcohol or drugs on the central nervous system, for the treatment of diabetes, hyperlipemia, hypohepatia, dysmesia or degeneration of erythrocytes, or to inhibit the proliferation of fat cells or reduce lipometabolism.

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