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1. 发明公开

EP0554032A3 Bicyclic suflur-containing compounds for the treatment of diseases coursed by immune system disorders compounds 失效
标题翻译：用于治疗由免疫系统疾病化合物治疗的疾病的双体含唾液酸化合物
公开(公告)号：EP0554032A3
公开(公告)日：1993-08-18
申请号：EP93300520.9
申请日：1993-01-25
申请人： SANTEN PHARMACEUTICAL CO., LTD.
发明人： Mita, Shiro , Kawashima, Yoichi , Fujimura, Ken-ichi , Suhara, Hiroshi , Okamoto, Masahiro
IPC分类号： C07D495/08 , A61K31/385 , A61K31/40
CPC分类号： C07D495/08
摘要： A compound of the formula [I] or a pharmaceutically acceptable salt thereof,

wherein,
R¹ and R² are the same or different and each is hydrogen or lower alkyl;
R³ and R⁴ are the same or different and each is hydrogen, lower alkyl, carboxy or lower alkoxycarbonyl;
R⁵ is hydrogen or lower alkyl;
X is oxygen or NR⁶;
R⁶ is hydrogen, lower alkyl, lower alkoxy, phenyl lower alkyl or phenyl lower alkoxy, and the said lower alkyl can be substituted by carboxy, lower alkoxycarbonyl, amino, lower alkylamino, lower alkoxycarbonylamino or phenyl lower alkylamino, and the phenyl ring of the said phenyl lower alkyl, phenyl lower alkoxy or phenyl lower alkylamino can be substituted by lower alkyl, lower alkoxy, halogen, carboxy or lower alkoxycarbonyl;
A is straight or branched lower alkylene,
n is 0 or 1. Such compound is useful for the treatment of various diseases caused by immune disorders such as immunodeficiency and autoimmune diseases.

2. 发明授权

EP0554032B1 Bicyclic suflur-containing compounds for the treatment of diseases coursed by immune system disorders compounds 失效
标题翻译：含硫双环化合物造成的免疫系统紊乱的疾病的治疗
公开(公告)号：EP0554032B1
公开(公告)日：1999-09-01
申请号：EP93300520.9
申请日：1993-01-25
申请人： SANTEN PHARMACEUTICAL CO., LTD.
发明人： Mita, Shiro , Kawashima, Yoichi , Fujimura, Ken-ichi , Suhara, Hiroshi , Okamoto, Masahiro
IPC分类号： C07D495/08 , A61K31/385 , A61K31/40
CPC分类号： C07D495/08

3. 发明公开

EP0554032A2 Bicyclic suflur-containing compounds for the treatment of diseases coursed by immune system disorders compounds 失效
标题翻译：引起的疾病的免疫系统障碍的治疗双环含硫化合物。
公开(公告)号：EP0554032A2
公开(公告)日：1993-08-04
申请号：EP93300520.9
申请日：1993-01-25
申请人： SANTEN PHARMACEUTICAL CO., LTD.
发明人： Mita, Shiro , Kawashima, Yoichi , Fujimura, Ken-ichi , Suhara, Hiroshi , Okamoto, Masahiro
IPC分类号： C07D495/08 , A61K31/385 , A61K31/40
CPC分类号： C07D495/08
摘要： A compound of the formula [I] or a pharmaceutically acceptable salt thereof,

wherein,
R¹ and R² are the same or different and each is hydrogen or lower alkyl;
R³ and R⁴ are the same or different and each is hydrogen, lower alkyl, carboxy or lower alkoxycarbonyl;
R⁵ is hydrogen or lower alkyl;
X is oxygen or NR⁶;
R⁶ is hydrogen, lower alkyl, lower alkoxy, phenyl lower alkyl or phenyl lower alkoxy, and the said lower alkyl can be substituted by carboxy, lower alkoxycarbonyl, amino, lower alkylamino, lower alkoxycarbonylamino or phenyl lower alkylamino, and the phenyl ring of the said phenyl lower alkyl, phenyl lower alkoxy or phenyl lower alkylamino can be substituted by lower alkyl, lower alkoxy, halogen, carboxy or lower alkoxycarbonyl;
A is straight or branched lower alkylene,
n is 0 or 1. Such compound is useful for the treatment of various diseases caused by immune disorders such as immunodeficiency and autoimmune diseases.
摘要翻译：式[I]或其药学上可接受的盐的化合物， worin，R <1>和R <2>是相同的或不同的，各自为氢或低级烷基; [R <3>和R <4>相同或不同，各自为氢，低级烷基，羧基或低级烷氧基羰; [R <5>是氢或低级烷基; X是氧或NR <6>; [R <6>是氢，低级烷基，低级烷氧基，苯基低级烷基或苯基低级烷氧基，和所述低级烷基可以被羧基被substituiertem，低级烷氧基羰基，氨基，低级烷基氨基，低级烷氧基羰基或苯基低级烷基氨基，且所述苯基的所述苯基低级烷基的环，苯基低级烷氧基或苯基低级烷基氨基可被低级烷基，低级烷氧基，卤素，羧基或低级烷氧羰substituiertem; A是直链或支链低级亚烷基，n是0或1.搜索化合物是用于通过免疫失调引起的各种疾病的治疗中有用：如免疫缺陷和自身免疫疾病。

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