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1. 发明公开

EP0351354A3 Somatostatin derivatives for the treatment of arthritis 失效
标题翻译：用于治疗ARTHRITIS的SOMATOSTATIN衍生物
公开(公告)号：EP0351354A3
公开(公告)日：1991-11-06
申请号：EP89810418.7
申请日：1989-06-05
申请人： SANDOZ AG
发明人： Feyen, Jean Honoré M. , Pless, Janos
IPC分类号： A61K37/43 , A61K37/02
CPC分类号： C07K14/6555 , A61K38/31
摘要： Somatostatin analogues and derivatives in free form or in pharmaceutically acceptable salt or complex form are useful for treating degenerative and inflammatory processes in bone or cartilage, e.g. arthritic conditions or diseases.

2. 发明公开

EP0331640A3 Use of an interleukin-6 molecule in inhibiting bone resorption 失效
标题翻译：使用白细胞介素-6分子抑制骨骼再分配
公开(公告)号：EP0331640A3
公开(公告)日：1991-03-13
申请号：EP89810155.5
申请日：1989-02-28
申请人： SANDOZ AG
发明人： Feyen, Jean Honoré M. , Trechsel, Ulrich
IPC分类号： A61K37/02
CPC分类号： A61K38/204
摘要： We have found that IL-6 molecules are useful in inhibiting bone resorption and increasing bone formation. They are thus useful in treating osteoporosis, e.g. acute and/or chronic stages of postmenopausal osteoporosis, including primary and/or secondary osteoporosis and localized osteoporosis, posttraumatic osteoporosis, Paget's disease of bone (osteitis deformans), osteolysis due to bone malignancies, e.g. osteogenic sarcoma, osteodystrophy, e.g. renal osteodystrophy, osteomalacia, multiple myeloma of the bone, osteogenesis imperfecta, hypercalcemia, osteomyelitis, e.g. in conjunction with antibiotics and ectopic calcification.

3. 发明公开

EP0351354A2 Somatostatin derivatives for the treatment of arthritis 失效
标题翻译：生长抑素诱导zur Behandlung der关节炎。
公开(公告)号：EP0351354A2
公开(公告)日：1990-01-17
申请号：EP89810418.7
申请日：1989-06-05
申请人： SANDOZ AG
发明人： Feyen, Jean Honoré M. , Pless, Janos
IPC分类号： A61K37/43 , A61K37/02
CPC分类号： C07K14/6555 , A61K38/31
摘要： Somatostatin analogues and derivatives in free form or in pharmaceutically acceptable salt or complex form are useful for treating degenerative and inflammatory processes in bone or cartilage, e.g. arthritic conditions or diseases.
摘要翻译：游离形式或药学上可接受的盐或复合形式的生长抑素类似物和衍生物可用于治疗骨或软骨中的退行性和炎性过程，例如，关节炎病症或疾病。

4. 发明公开

EP0331640A2 Use of an interleukin-6 molecule in inhibiting bone resorption 失效
标题翻译： Verwendung eines Interleukin-6-Molekuls zur Verhinderung von Knochenresorption。
公开(公告)号：EP0331640A2
公开(公告)日：1989-09-06
申请号：EP89810155.5
申请日：1989-02-28
申请人： SANDOZ AG
发明人： Feyen, Jean Honoré M. , Trechsel, Ulrich
IPC分类号： A61K37/02
CPC分类号： A61K38/204
摘要： We have found that IL-6 molecules are useful in inhibiting bone resorption and increasing bone formation. They are thus useful in treating osteoporosis, e.g. acute and/or chronic stages of postmenopausal osteoporosis, including primary and/or secondary osteoporosis and localized osteoporosis, posttraumatic osteoporosis, Paget's disease of bone (osteitis deformans), osteolysis due to bone malignancies, e.g. osteogenic sarcoma, osteodystrophy, e.g. renal osteodystrophy, osteomalacia, multiple myeloma of the bone, osteogenesis imperfecta, hypercalcemia, osteomyelitis, e.g. in conjunction with antibiotics and ectopic calcification.
摘要翻译：我们发现IL-6分子可用于抑制骨吸收和增加骨形成。因此它们可用于治疗骨质疏松症，例如绝经后骨质疏松症的急性和/或慢性阶段，包括原发性和/或继发性骨质疏松症和局部骨质疏松症，创伤后骨质疏松症，骨盆畸形骨畸形（骨折性变性骨质疏松症），由于骨恶性肿瘤引起的骨质疏松症。成骨肉瘤，骨营养不良等。肾性骨营养不良，骨软化，骨髓多发性骨髓瘤，成骨不全，高钙血症，骨髓炎等。结合抗生素和异位钙化。

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