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    • 5. 发明公开
    • POUDRE DE CRISTAUX DE MANNITOL DEFINE, SON PROCEDE DE FABRICATION
    • POUDRE DE CRISTAUX DE MANNITOL DEFINE,SON PROCEDE DE FABRICATION
    • EP2473465A1
    • 2012-07-11
    • EP10763795.1
    • 2010-09-01
    • Roquette Freres
    • BOIT, BaptisteLEFEVRE, PhilippeLIS, José
    • C07C29/78C07C31/26
    • C07C29/78A61K9/2018C07C31/26C07H1/06Y10T428/2982
    • The invention relates to a powder composition of mannitol crystals, produced by: (i) the crystallization of mannitol in a solvent; followed by (ii) a step of separating the crystals from the resulting crystal suspension; (iii) a step of drying said crystals; and (iv) a selection step, said composition having a particle size distribution, as determined by laser particle sizing, of 72 to 99.9 vol % of particles having a particle size greater than 75 μm, of 0.1 to 60 vol % of particles larger than 250 μm, and a mean diameter of between 100 and 300 μm. The invention also relates to a method for producing such a composition by means of a step of crystallizing a mannitol syrup followed by drying the mannitol crystals, a step of selecting particles, and a step of collecting a fraction of the powder composition including 72 to 99.9 % of particles having a particle size greater than 75 μm.
    • 本发明涉及甘露糖醇结晶的粉末组合物,其通过以下制备:(i)甘露醇在溶剂中的结晶; 随后(ii)从所得晶体悬浮液中分离晶体的步骤; (iii)干燥所述晶体的步骤; 和(iv)选择步骤,所述组合物具有通过激光粒度测定确定的粒度分布,72至99.9体积%的粒度大于75μm的粒子,0.1至60体积%的粒子大于 250微米,平均直径在100和300微米之间。 本发明还涉及通过使甘露醇糖浆结晶然后干燥甘露糖醇晶体的步骤,选择颗粒的步骤以及收集包含72至99.9的粉末组合物的步骤的步骤 %粒径大于75μm的颗粒。