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1. 发明公开

EP3008454A1 METHOD AND SYSTEM FOR DETECTING AN ANALYTE IN A BODY FLUID 有权
标题翻译： VERFAHREN UND系统FÜRDEN NACHWEIS EINESTEN IN EINERKÖRPERFLÜSSIGKEIT
公开(公告)号：EP3008454A1
公开(公告)日：2016-04-20
申请号：EP14708819.9
申请日：2014-02-24
申请人： Roche Diagnostics GmbH , F.Hoffmann-La Roche AG
发明人： BAUER-ESPINDOLA, Klaus Andreas , HORN, Carina , MARQUANT, Michael , NORTMEYER, Christine , UNKRIG, Volker
IPC分类号： G01N21/84 , G01N21/64 , G01N27/327 , G01N27/02
CPC分类号： G01N33/492 , G01N21/6428 , G01N21/78 , G01N21/8483 , G01N27/02 , G01N27/12 , G01N27/3274 , G01N2021/7786
摘要： A method for detecting at least one analyte in a body fluid (112) is disclosed. The method comprises the following steps: a) performing an optical measurement, wherein at least one test chemical (120) is contacted with the body fluid (112), wherein the test chemical (120) is an optical test chemical (120) and is adapted to perform at least one detection reaction in the presence of the analyte, wherein at least one optically detectable property of at least one of the body fluid (112) and the test chemical (120) is changed due to the detection reaction, wherein at least one optical measurement value is generated; b) performing at least one impedance measurement, wherein at least two impedance measurement electrodes (130) are used, wherein at least one alternating electrical signal is applied to the body fluid (112) via the impedance measurement electrodes (130) and wherein at least one answer signal is recorded, wherein at least one impedance measurement value is generated; c) performing at least one evaluation step, wherein, in the evaluation step, at least one evaluation algorithm is used, wherein the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid (112).
摘要翻译：公开了一种用于检测体液中的至少一种分析物的方法，包括执行光学测量，其中至少一种测试化学品接触体液。测试化学品是适于进行至少一种检测反应的光学测试化学品，其中由于检测反应而改变至少一种可光学检测的性质以提供至少一种光学测量值。产生至少一个阻抗测量，其中经由阻抗测量电极将至少一个交流电信号施加到体液，并记录至少一个应答信号，并且产生至少一个阻抗测量值。执行至少一个评估步骤，其中使用至少一个评估算法，并且使用光学测量值和阻抗测量值来确定体液中分析物的浓度。

2. 发明授权

EP3408401B1 ELECTROCHEMILUMINESCENCE METHOD AND APPARATUS FOR DETECTING AN ANALYTE IN A LIQUID SAMPLE 有权
公开(公告)号：EP3408401B1
公开(公告)日：2019-11-20
申请号：EP17702082.3
申请日：2017-01-27
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： QUINT, Stefan , BAUER-ESPINDOLA, Klaus Andreas
IPC分类号： C12Q1/00 , G01N33/543 , G01N33/58

3. 发明公开

EP3234565A1 TEST ELEMENT FOR ELECTROCHEMICALLY DETECTING AT LEAST ONE ANALYTE 无效
标题翻译：用于至少一个分析物的电化学检测的测试元件
公开(公告)号：EP3234565A1
公开(公告)日：2017-10-25
申请号：EP15813379.3
申请日：2015-12-17
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： BAUER-ESPINDOLA, Klaus Andreas , MARQUANT, Michael , NORTMEYER, Christine , STEIN, Reiner
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/006 , G01N27/3274
摘要： A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.
摘要翻译：公开了用于电化学检测体液中的至少一种分析物的测试元件（110）。测试元件（110）包括至少一个第一电极（116）和至少一个第二电极（118）。第一电极（116）被设计为工作电极并且第二电极被设计为反电极。测试元件（110）包括至少一个能够接收体液样本的毛细管（160）。第一电极（116）和第二电极（118）布置在毛细管（160）的相对侧上。第一电极（116）和第二电极（118）被布置成使得在毛细填充期间，第一电极（116）和第二电极（118）同时并且以相等的速率润湿。

4. 发明公开

EP3131882A1 PHENAZINIUM MEDIATORS 有权
标题翻译：噻吩类媒介物
公开(公告)号：EP3131882A1
公开(公告)日：2017-02-22
申请号：EP15718466.4
申请日：2015-04-13
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： HEINDL, Dieter , NORTMEYER, Christine , GEBAUER, Peter , HUNT DU VALL, Stacy , BAUER-ESPINDOLA, Klaus Andreas
IPC分类号： C07D241/46
摘要： The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the aforesaid chemical compound. Moreover, the present invention relates to a method for determining the amount of an analyte in a sample, comprising contacting said sample with a chemistry matrix according to the present invention, estimating the amount of electrons liberated or consumed by the chemistry matrix in the presence of said liquid sample, and thereby determining the amount of an analyte in a liquid sample.
摘要翻译：本发明涉及作为1-氨基 - 吩嗪衍生物的化合物或其盐或溶剂化物，并涉及其用途。本发明还涉及化学基质和包含上述化学化合物的测试元件。此外，本发明涉及用于确定样品中分析物的量的方法，该方法包括使所述样品与根据本发明的化学基质接触，估计在化学基质存在下释放或消耗的电子的量所述液体样品，从而确定液体样品中分析物的量。

5. 发明授权

EP3131882B1 PHENAZINIUM MEDIATORS 有权
公开(公告)号：EP3131882B1
公开(公告)日：2020-07-15
申请号：EP15718466.4
申请日：2015-04-13
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： HEINDL, Dieter , NORTMEYER, Christine , GEBAUER, Peter , HUNT DU VALL, Stacy , BAUER-ESPINDOLA, Klaus Andreas
IPC分类号： C07D241/46

6. 发明公开

EP3408401A1 ELECTROCHEMILUMINESCENCE METHOD AND APPARATUS FOR DETECTING AN ANALYTE IN A LIQUID SAMPLE 有权
公开(公告)号：EP3408401A1
公开(公告)日：2018-12-05
申请号：EP17702082.3
申请日：2017-01-27
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： QUINT, Stefan , BAUER-ESPINDOLA, Klaus Andreas
IPC分类号： C12Q1/00 , G01N33/543 , G01N33/58
摘要： The application relates to an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell (108), the measuring cell (108) comprising a working electrode (120) for detecting the analyte using an electrochemiluminescence measurement cycle, the method comprising a. carrying out the measurement cycle in a calibration process using a liquid sample void of the analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode (120), b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second E!S being performed using the working electrode (120), c. comparing the result of the first EIS and the second EIS, providing an indication of a measurement state indicating if the comparison results that a deviation between the first EIS and the second EIS is exceeding a predefined threshold.

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