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1. 发明授权

EP2297581B1 ASC AS A MARKER FOR LUNG CANCER 失效转让
标题翻译： ASC作为肺癌的标志物
公开(公告)号：EP2297581B1
公开(公告)日：2013-04-03
申请号：EP09772167.4
申请日：2009-07-01
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： ANDRES, Herbert , HAGMANN, Marie-Luise , KARL, Johann , ROESSLER, Markus , TACKE, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N2333/4742

2. 发明授权

EP2130048B1 APEX AS A MARKER FOR LUNG CANCER 失效
标题翻译： APEX作为标记物时为肺癌
公开(公告)号：EP2130048B1
公开(公告)日：2012-04-18
申请号：EP08716640.1
申请日：2008-03-19
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： HAGMANN, Marie-Luise , KARL, Johann , KLOECKNER, Julia , ROESSLER, Markus , TACKE, Michael , THIEROLF, Michael
IPC分类号： G01N33/574 , G01N33/573
CPC分类号： G01N33/57423 , G01N33/57488 , G01N2333/988
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein APEX in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring APEX in said sample. Measurement of APEX can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.

3. 发明公开

EP2404174A1 SERPIN B 13 AS A MARKER FOR SQUAMOUS CELL CARCINOMA OF THE LUNG 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂B-13作为标志物用于肺鳞状
公开(公告)号：EP2404174A1
公开(公告)日：2012-01-11
申请号：EP10707467.6
申请日：2010-03-02
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： ROESSLER, Markus , MANTOVANI-ENDL, Liliana , TACKE, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N2333/8121
摘要： The present invention relates to a method aiding in the assessment of squamous cell carcinoma (= SCC). It discloses the use of the protein serpin B13 as a marker of SCC. Furthermore, it relates to a method for assessing lung cancer in a tissue sample derived from a patient having non-small cell lung carcinoma (= NSCLC) and for differentiating SCC from adenocarcinoma or large cell carcinoma of the lung.

4. 发明公开

EP2380024A1 ARMET AS A MARKER FOR CANCER 失效
标题翻译： ARMET ALS KREBSMARKER
公开(公告)号：EP2380024A1
公开(公告)日：2011-10-26
申请号：EP09798890.1
申请日：2009-12-18
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： ROESSLER, Markus , KARL, Johann , RIEDLINGER, Julia , LINDNER, Ingo , TACKE, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , G01N33/57423 , G01N33/57484 , G01N2333/475 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the arginine-rich metastasized in early tumors protein (= ARMET) as a universal marker of different cancer types. ARMET aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g. of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are e.g. breast, ovary, cervix, head and neck, endometrium, melanoma, bladder, kidney, pancreas, prostate, esophagus, stomach or bile duct cancer. Furthermore, it especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring ARMET in said sample. Measurement of ARMET can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.
摘要翻译：披露了一种帮助评估癌症的方法。更具体地公开了在早期肿瘤蛋白（= ARMET）中转移的精氨酸富集作为不同癌症类型的通用标记物的用途。 ARMET有助于评估肺或肺癌（LC）或结肠癌，例如非小细胞肺癌（NSCLC）或结肠直肠癌（CRC），但也可能是其他特定类型的癌症。这些特定的癌症类型是例如乳腺，卵巢，子宫颈，头颈部，子宫内膜，黑素瘤，膀胱，肾，胰腺，前列腺，食道，胃或胆管癌。进一步公开了一种通过测量样品中的ARMET从个体获得的来自液体样品的癌症的方法。 ARMET的测量可以例如用于癌症的早期检测或用于进行手术的患者的监视。

5. 发明授权

EP1579220B1 USE OF NICOTINAMIDE N-METHYLTRANSFERASE AS A MARKER FOR COLORECTAL CANCER 有权
标题翻译：烟酰胺N-甲基对结肠直肠癌的诊断中的应用，
公开(公告)号：EP1579220B1
公开(公告)日：2007-08-15
申请号：EP03813582.8
申请日：2003-12-19
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： BERNDT, Peter , HAGMANN, Marie-Luise , LANGEN, Hanno , PALME, Stefan , ROESSLER, Markus , ROLLINGER, Wolfgang , TACKE, Michael , ZOLG, Werner , KARL, Johann , KOTT, Theresa
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , C12Q1/48
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.

6. 发明公开

EP1654541A1 USE OF PROTEIN PSA3 AS A MARKER FOR COLORECTAL CANCER 审中-公开
标题翻译：使用作为标记大肠肿瘤PSA3
公开(公告)号：EP1654541A1
公开(公告)日：2006-05-10
申请号：EP04763897.8
申请日：2004-08-06
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： TACKE, Michael , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , PALME, Stefan , ROESSLER, Markus , ROLLINGER, Wolfgang , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/95
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said sample. Measurement of PSA3 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

7. 发明授权

EP2356461B1 PACAP AS A MARKER FOR CANCER 失效
标题翻译： PACAP THAN癌症标志物
公开(公告)号：EP2356461B1
公开(公告)日：2013-10-09
申请号：EP09748720.1
申请日：2009-11-10
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： HAGMANN, Marie Luise , KARL, Johann , RIEDLINGER, Julia , ROESSLER, Markus , TACKE, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N33/57423

8. 发明公开

EP2223115A1 SEPRASE AS A MARKER FOR CANCER 有权
标题翻译： Seprase的THAN癌症标志物
公开(公告)号：EP2223115A1
公开(公告)日：2010-09-01
申请号：EP08859952.7
申请日：2008-12-08
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： ROLLINGER, Wolfgang , KARL, Johann , KOCHAN, Jarema, Peter , ROESSLER, Markus , TACKE, Michael
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N33/57407 , G01N33/57419 , G01N33/57473 , G01N2333/96411
摘要： The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the human fibroblast activation protein (FAP/seprase) as a universal marker of different cancer types. Seprase aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g. of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are e.g. esophagus, head and neck cancer, stomach cancer, bile duct cancer, pancreas cancer, kidney cancer, cervix cancer, ovary cancer, breast cancer, bladder cancer, endometrium cancer or prostate cancer. Furthermore, it especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring seprase in said sample. Measurement of seprase can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery.

9. 发明公开

EP2130048A1 APEX AS A MARKER FOR LUNG CANCER 失效
标题翻译： APEX作为标记物时为肺癌
公开(公告)号：EP2130048A1
公开(公告)日：2009-12-09
申请号：EP08716640.1
申请日：2008-03-19
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： HAGMANN, Marie-Luise , KARL, Johann , KLOECKNER, Julia , ROESSLER, Markus , TACKE, Michael , THIEROLF, Michael
IPC分类号： G01N33/574 , G01N33/573
CPC分类号： G01N33/57423 , G01N33/57488 , G01N2333/988
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein APEX in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring APEX in said sample. Measurement of APEX can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.

10. 发明公开

EP1654542A1 USE OF PROTEIN SPERMIDINE SYNTHASE (SPEE) AS A MARKER FOR COLORECTAL CANCER 有权
标题翻译：中蛋白质亚精胺合酶（SPEE）作为标志物用于结肠直肠癌USE
公开(公告)号：EP1654542A1
公开(公告)日：2006-05-10
申请号：EP04763899.4
申请日：2004-08-06
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： TACKE, Michael , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , PALME, Stefan , ROESSLER, Markus , ROLLINGER, Wolfgang , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/91171
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein SPEE (spermidine synthase) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring SPEE in said sample. Measurement of SPEE can, e.g., be used in the early detection or diagnosis of colorectal cancer.

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