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1. 发明公开

EP4184173A1 AUTOMATED ANALYTICAL SYSTEM FOR PROCESSING BIOLOGICAL SAMPLES 审中-实审
公开(公告)号：EP4184173A1
公开(公告)日：2023-05-24
申请号：EP21208792.8
申请日：2021-11-17
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： BAGGIO, Fabian , EGLI, Roman , ETTEL, Christian , GUT, Raphael , HERMANN, Pius , KORJAGIN, Nikifor , MEIER, Alexander , SCHLAUBITZ, Thomas , SCHNEEBELI, Rolf , SIEGENTHALER, Simon , VICENTE LEITAO, Ivo Daniel , VOLLENWEIDER, Stefan
IPC分类号： G01N35/02 , G01N35/00 , G01N35/04
摘要： The present disclosure relates to aspects of an automated analytical system. In particular, it relates to a method for introducing a sample rack holding a plurality of sample receptacles into a receiving bay in a housing of an automated analytical system. The method is carried out by manually moving the sample rack from a loading position towards a processing position along a lane in the receiving bay. The movement is paused when the rack reaches a focusing position between the two above-mentioned terminal positions, where a proximal stopping element provides sufficient resistance for the movement of the rack to be hindered. In this position, a reader in essentially the same horizontal plane is moved so as to focus on the lane in the receiving bay and thus the sample rack being inserted into the lane. With the reader so focused, the movement of the sample rack towards the processing position is resumed past the proximal stopping element and all the way to the processing position, while the reader detects features of the sample rack and/or the plurality of sample receptacles. The processing position is defined by a distal stopping element, marking the endpoint of the insertional movement of the sample rack. In this terminal position, the rack is positioned, detected in this position, and then locked for alignment with regard to the following processing of the content of the sample receptacles.

2. 发明公开

EP3524353A1 DEVICE FOR THERMOCYCLING BIOLOGICAL SAMPLES, MONITORING INSTRUMENT COMPRISING THE SAME, AND METHOD FOR THERMOCYCLING BIOLOGICAL SAMPLES USING SUCH DEVICE 审中-公开
公开(公告)号：EP3524353A1
公开(公告)日：2019-08-14
申请号：EP18156326.3
申请日：2018-02-12
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： FEDERER, Paul , EBERT, Sven , HERMANN, Pius , VOLLENWEIDER, Stefan
IPC分类号： B01L7/00
摘要： The present invention provides a device for thermocycling biological samples, the device comprising a mount for receiving the biological samples, a heat pump for heating and cooling the mount, wherein the heat pump is thermally coupled to the mount, a heat sink comprising a primary heat exchanger with an inner space perfused by a heat exchanging fluid, and a secondary heat exchanger, wherein the primary heat exchanger is thermally coupled to the heat pump, and wherein the secondary heat exchanger is thermally coupled to the heat pump through the primary heat exchanger, and a control unit for controlling the thermocycling of the biological samples. The present invention further provides an instrument for simultaneously monitoring multiple nucleic acid amplification reactions during thermocycling biological samples by means of such device, and also to a method for thermocycling biological samples using such device for thermocycling biological samples.

3. 发明公开

EP3465225A1 LABORATORY SAMPLE DISTRIBUTION SYSTEM AND LABORATORY AUTOMATION SYSTEM 有权
公开(公告)号：EP3465225A1
公开(公告)日：2019-04-10
申请号：EP17726001.5
申请日：2017-05-31
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： HERMANN, Pius , BAER, Jonathan
IPC分类号： G01N35/04 , B65G54/02

4. 发明公开

EP3420366A1 TRANSPORT DEVICE HAVING A TILED DRIVING SURFACE 审中-公开
公开(公告)号：EP3420366A1
公开(公告)日：2019-01-02
申请号：EP17701159.0
申请日：2017-01-25
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： KÄPPELI, Marcel , HUBER, Tobias , HERMANN, Pius , EDELMANN, Matthias
IPC分类号： G01N35/04 , B65G54/02 , G01N35/00

5. 发明公开

EP3211427A1 SAMPLE CONTAINER CARRIER 审中-公开
标题翻译：样品容器载体
公开(公告)号：EP3211427A1
公开(公告)日：2017-08-30
申请号：EP16157465.2
申请日：2016-02-25
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： KÄPPELI, Marcel , HERMANN, Pius
IPC分类号： G01N35/04 , B01L9/06
CPC分类号： G01N35/04 , B01L3/5453 , B01L9/06 , B01L2200/025 , B01L2200/18 , G01N2035/0401 , G01N2035/0406
摘要： The invention relates to a sample container carrier for transporting sample containers, for example test tubes and/or vials, in a laboratory automation system, the sample container carrier comprising a basic body (2) having a hollow (20) with a central axis (A), wherein the hollow (20) is adapted for receiving a lower end of a sample container (10), and at least three resiliently deformable and/or displaceable upper retaining elements (3), wherein the upper retaining elements (3) are distributed about the central axis (A) and adapted to clamp a sample container (10) inserted in the hollow (20) of the basic body (2), and wherein the upper retaining elements (3) are made of a plastic material. The invention further relates to a method for manufacturing a sample container carrier, wherein that at least the upper retaining elements (30) are formed by injection molding. In addition, the invention relates to a laboratory sample distribution system having a number of sample container carriers, and a laboratory automation system comprising a laboratory sample distribution system.
摘要翻译：本发明涉及一种用于在实验室自动化系统中运输样品容器（例如试管和/或小瓶）的样品容器载体，该样品容器载体包括具有中空轴（20）的基体（2）其特征在于，所述空腔（20）适于接收样本容器（10）的下端，以及至少三个可弹性变形和/或可移位的上保持元件（3），其中所述上保持元件（3）围绕中心轴线（A）分布并适于夹持插入基体（2）的中空部分（20）中的样本容器（10），并且其中上部保持元件（3）由塑料材料制成。本发明还涉及一种用于制造样本容器载体的方法，其中至少上部保持元件（30）通过注射成型形成。此外，本发明涉及具有多个样品容器载体的实验室样品分配系统以及包括实验室样品分配系统的实验室自动化系统。

6. 发明公开

EP3420367A1 TRANSPORT DEVICE WITH BASE PLATE MODULES 有权
公开(公告)号：EP3420367A1
公开(公告)日：2019-01-02
申请号：EP17701160.8
申请日：2017-01-25
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： KÄPPELI, Marcel , HUBER, Tobias , HERMANN, Pius , EDELMANN, Matthias
IPC分类号： G01N35/04 , B65G54/02

7. 发明公开

EP3211426A1 SAMPLE CONTAINER CARRIER 无效
标题翻译：样品容器载体
公开(公告)号：EP3211426A1
公开(公告)日：2017-08-30
申请号：EP16157464.5
申请日：2016-02-25
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： KÄPPELI, Marcel , HERMANN, Pius
IPC分类号： G01N35/04 , B01L9/06
CPC分类号： G01N35/04 , B01L3/5453 , B01L9/06 , B01L2200/025 , B01L2200/18 , G01N2035/0401 , G01N2035/0406
摘要： The invention relates to a sample container carrier for transporting sample containers, for example test tubes and/or vials, in a laboratory automation system, the sample container carrier comprising a basic body (2) having a hollow (20) with a central axis (A), wherein the hollow (20) is adapted for accommodating a lower end of a sample container (5), at least three resiliently deformable and/or displaceable first retaining elements (30) mounted to the basic body (2), wherein the first retaining elements (3) are distributed about the central axis (A) and adapted to clamp a sample container (5) inserted in the hollow (20) of the basic body (2), and at least three resiliently deformable and/or displaceable second retaining elements (32) mounted to the basic body (2), wherein the second retaining elements (32) are distributed about the central axis (A) and adapted to clamp the sample container (5) inserted in the hollow (20) of the basic body (2) underneath the at least three first retaining elements (30), and wherein the second retaining elements (32) are arranged at least partly inside the hollow (20) of the basic body (2). The invention further relates to a laboratory sample distribution system having a number of sample containers, and a laboratory automation system comprising a laboratory sample distribution system.
摘要翻译：本发明涉及一种用于在实验室自动化系统中运输样品容器（例如试管和/或小瓶）的样品容器载体，该样品容器载体包括具有中空轴（20）的基体（2）（20）适于容纳样本容器（5）的下端，至少三个可弹性变形和/或可移位的第一保持元件（30）安装到基体（2）上，其中，第一保持元件（3）围绕中心轴线（A）分布并适于夹持插入基体（2）的空腔（20）中的样品容器（5），并且至少三个可弹性变形和/或可移位（2）上的第二保持元件（32），其中所述第二保持元件（32）围绕所述中心轴线（A）分布并且适于夹持插入所述中空轴（20）中的所述样本容器（5）在至少三个第一零售店下面的基体（2）（30），并且其中所述第二保持元件（32）至少部分地布置在所述基体（2）的所述中空部（20）内。本发明还涉及具有多个样品容器的实验室样品分配系统以及包括实验室样品分配系统的实验室自动化系统。

8. 发明公开

EP4371741A1 METHOD FOR MONITORING THE SEALING OF A CONTAINER AND DEVICE WITH IMPROVED SEALING MONITORING 审中-公开
公开(公告)号：EP4371741A1
公开(公告)日：2024-05-22
申请号：EP22207916.2
申请日：2022-11-16
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： VOLLENWEIDER, Stefan , FEDERER, Paul , HERMANN, Pius
IPC分类号： B29C65/18 , B29C65/30
CPC分类号： B29C66/53461 , B29C66/131 , B29C66/112 , B29C66/8322 , B29C65/18 , B29C66/91231 , B29C66/91421 , B29C66/91951 , B29C66/91212 , B29C66/961 , B29C66/962 , B29C66/9221 , B29C65/30 , B29C66/849 , B29C66/742 , B29C66/7465 , B29C66/73921 , B29C66/723 , B29C66/91443
摘要： A method for monitoring the sealing of a container in system or device comprising the following steps: controlling the heating element (5) to heat a heating stamp (3) to a predetermined sealing temperature, monitoring the temperature of the heating stamp (3), determining a temperature over time curve (TT) of the heating stamp (3) by means of at least one temperature sensor (9), determining at least one characteristic of the temperature over time curve (TT), comparing the determined at least one characteristic of the temperature over time curve (TT) with a reference value, and a sealing property of the sealing of the container based on said comparison of the determined at least one characteristic of the temperature over time curve (TT) with the reference value.

9. 发明公开

EP3520893A1 SYSTEM FOR THE THERMALLY CONTROLLED PROCESSING OF A BIOLOGICAL SAMPLE 有权
公开(公告)号：EP3520893A1
公开(公告)日：2019-08-07
申请号：EP18154962.7
申请日：2018-02-02
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： BERNET, Roland , CHERUBINI, Claudio , HERMANN, Pius , SAROFIM, Emad
IPC分类号： B01L3/00 , B01L9/00
摘要： The present disclosure relates to a system for the thermally controlled processing of biological material in a liquid sample in a multiwell plate using magnetic particles. Also disclosed is a corresponding method for the thermally controlled processing of biological material in a liquid sample.

10. 发明授权

EP3520893B1 SYSTEM FOR THE THERMALLY CONTROLLED PROCESSING OF A BIOLOGICAL SAMPLE 有权
公开(公告)号：EP3520893B1
公开(公告)日：2020-07-22
申请号：EP18154962.7
申请日：2018-02-02
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： BERNET, Roland , CHERUBINI, Claudio , HERMANN, Pius , SAROFIM, Emad
IPC分类号： B01L3/00 , B01L9/00

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