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1. 发明公开

EP3335047A1 ALKALINE PRETREATMENT OF PARVOVIRUSES FOR IMMUNOASSAYS 有权
公开(公告)号：EP3335047A1
公开(公告)日：2018-06-20
申请号：EP16757178.5
申请日：2016-08-11
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： FAATZ, Elke , MUENCH, Peter , RITTER, Mirko , TABARES, Gloria
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N33/54393 , G01N2333/015
摘要： The present invention relates to a method for detecting a capsid polypeptide of a non-enveloped virus in a sample from a subject comprising (a) contacting said sample with a base, and (b) detecting a capsid polypeptide of said virus in said sample. Moreover, the present invention relates to a method for pre-processing a sample from a subject for detection of a virus, comprising contacting said sample with a base. Moreover, the present invention relates to kits, uses and devices related to said methods.

2. 发明公开

EP1402015A2 A SOLUBLE COMPLEX COMPRISING A RETROVIRAL SURFACE GLYCOPROTEIN 有权
标题翻译：逆转录病毒表面的糖蛋白和OR FkpA的SlyD含有可溶性络合物
公开(公告)号：EP1402015A2
公开(公告)日：2004-03-31
申请号：EP02758265.9
申请日：2002-06-24
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： SCHOLZ, Christian , ANDRES, Herbert , FAATZ, Elke , ENGEL, Alfred , SIZMANN, Dorothea
IPC分类号： C12N9/90
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)- chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively are also described.

3. 发明公开

EP3615553A1 SOLUBLE AND IMMUNOREACTIVE FLAVIVIRAL NS1 POLYPEPTIDES 审中-实审
公开(公告)号：EP3615553A1
公开(公告)日：2020-03-04
申请号：EP18721311.1
申请日：2018-04-23
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： FAATZ, Elke , RIEDEL, Alexander , SCHOLZ, Christian , MUENCH, Peter , TABARES, Gloria , GLOECK, Mario , LUEBCKE, Silke , BENZ, Juliane
IPC分类号： C07K14/18 , G01N33/569

4. 发明公开

EP3130922A1 ALKALINE PRETREATMENT OF PARVOVIRUSES FOR IMMUNOASSAYS 审中-公开
标题翻译： ALKALISCHE VORBEHANDLUNG VON PARVOVIRENFÜRIMMUNOASSAYS
公开(公告)号：EP3130922A1
公开(公告)日：2017-02-15
申请号：EP15180536.3
申请日：2015-08-11
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： FAATZ, Elke , MÜNCH, Peter , RITTER, Mirko , TABARES, Gloria
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N33/54393 , G01N2333/015
摘要： The present invention relates to a method for detecting a capsid polypeptide of a non-enveloped virus in a sample from a subject comprising (a) contacting said sample with a base, and (b) detecting a capsid polypeptide of said virus in said sample. Moreover, the present invention relates to a method for pre-processing a sample from a subject for detection of a virus, comprising contacting said sample with a base. Moreover, the present invention relates to kits, uses and devices related to said methods.
摘要翻译：本发明涉及一种检测来自受试者的样品中非包膜病毒的衣壳多肽的方法，包括（a）使所述样品与碱接触，和（b）在所述样品中检测所述病毒的衣壳多肽。此外，本发明涉及一种用于预处理来自受试者的用于检测病毒的样品的方法，包括使所述样品与碱接触。此外，本发明涉及与所述方法相关的试剂盒，用途和装置。

5. 发明授权

EP3230739B1 METHOD FOR MEASUREMENT OF VITAMIN D 有权
公开(公告)号：EP3230739B1
公开(公告)日：2019-01-23
申请号：EP15804807.4
申请日：2015-12-04
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： FAATZ, Elke , GERG, Michael , JOSEL, Hans-Peter , VOGL, Christian
IPC分类号： G01N33/537 , G01N33/541

6. 发明授权

EP3335047B1 ALKALINE PRETREATMENT OF PARVOVIRUSES FOR IMMUNOASSAYS 有权
公开(公告)号：EP3335047B1
公开(公告)日：2019-06-19
申请号：EP16757178.5
申请日：2016-08-11
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： FAATZ, Elke , MUENCH, Peter , RITTER, Mirko , TABARES, Gloria
IPC分类号： G01N33/569

7. 发明公开

EP3230739A1 METHOD FOR MEASUREMENT OF VITAMIN D 有权
标题翻译：测量维生素D的方法
公开(公告)号：EP3230739A1
公开(公告)日：2017-10-18
申请号：EP15804807.4
申请日：2015-12-04
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： FAATZ, Elke , GERG, Michael , JOSEL, Hans-Peter , VOGL, Christian
IPC分类号： G01N33/537 , G01N33/541
CPC分类号： G01N33/537 , C07K16/26 , G01N33/541 , G01N33/82
摘要： The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin D, wherein the potentially interfering compound 24,25-dihydroxyvitamin D3 is blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin D3 and not binding to 25-hydroxyvitamin D.
摘要翻译：本发明涉及用于测量25-羟基维生素D的体外方法，其中潜在干扰化合物24,25-二羟基维生素D 3被特异性结合24,25-二羟基维生素D 3且不与25-二羟基维生素D 3结合的结合剂封闭。羟维生素D

8. 发明授权

EP1578793B1 SOLUBLE COMPLEXES OF TARGET PROTEINS AND PEPTIDYL PROLYL ISOMERASE CHAPERONES AND METHODS OF MAKING AND USING THEM 有权
标题翻译：靶蛋白和肽基脯氨酰异构酶分子伴侣及其生产和使用可溶性络合物
公开(公告)号：EP1578793B1
公开(公告)日：2007-10-03
申请号：EP02798355.0
申请日：2002-12-20
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： FAATZ, Elke , SCHOLZ, Christian , SCHAARSCHMIDT, Peter
IPC分类号： C07K14/47 , C12N15/62 , C12N9/90 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6896 , C07K14/4711 , C12N9/90 , C12Y502/01008 , G01N2333/4709 , G01N2800/2821
摘要： The present invention relates to the diagnosis of Alzheimer's Disease. It especially teaches the production of a soluble Abeta-chaperone complex and wherein the chaperone is a member of the Ppplase family and the advantageous use of such chaperone-Abeta complex, especially in the detection of Abeta in an immunoassay, as well as its use as an immunogen.

9. 发明公开

EP3615554A1 SOLUBLE AND IMMUNOREACTIVE ZIKA VIRUS NS1 POLYPEPTIDES 审中-公开
公开(公告)号：EP3615554A1
公开(公告)日：2020-03-04
申请号：EP18721312.9
申请日：2018-04-23
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： FAATZ, Elke , GLOECK, Mario , MUENCH, Peter , RIEDEL, Alexander , SCHOLZ, Christian , TABARES, Gloria
IPC分类号： C07K14/18 , G01N33/569

10. 发明公开

EP3110831A2 SOLUBLE AND IMMUNOREACTIVE VARIANTS OF HTLV CAPSID ANTIGEN P24 有权
标题翻译： LÖSLICHE免疫缺陷型变态反应型HTLV-KAPSID-ANTIGENS P24
公开(公告)号：EP3110831A2
公开(公告)日：2017-01-04
申请号：EP15706804.0
申请日：2015-02-26
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： FAATZ, Elke , MUENCH, Peter , SCHOLZ, Christian
IPC分类号： C07K14/005 , G01N33/569
CPC分类号： G01N33/56988 , C07K14/005 , C07K2319/35 , C12N2740/14022 , C12N2740/14031 , C12N2740/14051 , G01N33/56983 , G01N2333/15 , G01N2469/20
摘要： The invention concerns soluble and antigenic HTLV p24 variants that are fused to chaperones and their use in diagnostic applications such as immunoassays for detecting antibodies against HTLV-I or HTLV-II in an isolated biological sample. In particular, the invention relates to a soluble HTLV-I or HTLV-II p24 antigen comprising a fragment of at least 25 amino acids of SEQ ID NOs. 1 or 4 (HTLV-1) or SEQ ID NOs. 5 or 8 (HTLV-II), wherein the HTLV p24 antigen is fused to a chaperone. Moreover, the invention covers recombinant DNA molecules encoding these HTLV-I and -II fusion antigens as well as their recombinant production using expression vectors and host cells transformed with such expression vectors. In addition, the invention focusses on compositions of these HTLV p24 antigens with HTLV gp21 antigen and on an immunoassay method for detection of HTLV antibodies using the antigens of the invention. Also the use of HTLV p24 antigens in an in vitro diagnostic assay as well as a reagent kit for detection of anti-HTLV-antibodies comprising said HTLV antigens is encompassed.
摘要翻译：本发明涉及与分子伴侣融合的可溶性和抗原性HTLV p24变体及其在诊断应用中的用途，例如用于检测分离的生物样品中针对HTLV-1或HTLV-II的抗体的免疫测定。特别地，本发明涉及包含SEQ ID NOs至少25个氨基酸的片段的可溶性HTLV-1或HTLV-II p24抗原。 1或4（HTLV-1）或SEQ ID NO。 5或8（HTLV-II），其中HTLV p24抗原与伴侣融合。此外，本发明涵盖了编码这些HTLV-1和-II融合抗原的重组DNA分子以及使用表达载体和用这些表达载体转化的宿主细胞的重组生产。此外，本发明集中于这些HTLV p24抗原与HTLV gp21抗原的组合物和使用本发明的抗原检测HTLV抗体的免疫测定方法。还包括在体外诊断测定中使用HTLV p24抗原以及用于检测包含所述HTLV抗原的抗HTLV抗体的试剂盒。

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