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1. 发明公开

EP3124622A1 FLUORESCENT LABELED SINGLE-STRANDED NUCLEIC ACID AND USE THEREOF 有权转让
标题翻译：维多利亚·马尔吉斯特EINZELSTRÄNGIGENUKLEINSÄUREUND VERWENDUNG DAVON
公开(公告)号：EP3124622A1
公开(公告)日：2017-02-01
申请号：EP15773110.0
申请日：2015-03-27
申请人： Riken , Kabushiki Kaisha DNAFORM
发明人： HANAMI Takeshi , HAYASHIZAKI Yoshihide , SOMA Takahiro , KIMURA Yasumasa
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/542
摘要： The present invention is intended to provide a novel fluorescent labeled single-stranded nucleic acid, by which the background of an exciton oligomer can be further reduced and the novel use thereof. The present invention relates to a labeled single-stranded nucleic acid having at least two fluorescent atomic group pairs that exhibit an exciton effect. The labeled single-stranded nucleic acid is characterized in that the emission peak wavelength of one of the fluorescent atomic group pairs (fluorescent atomic group pair A) is shorter than the excitation peak wavelength of the other fluorescent atomic group pair (fluorescent atomic group pair B), and the fluorescent atomic group pairs A and B have a Forster resonance energy transfer (FRET) effect. This fluorescent labeled single-stranded nucleic acid is usable as a primer for amplifying a target nucleic acid or a probe to be hybridized with a target nucleic acid.
摘要翻译：本发明旨在提供一种新的荧光标记单链核酸，通过其可以进一步降低激子低聚物的背景及其新用途。本发明涉及具有表现出激子效应的至少两个荧光原子团对的标记单链核酸。标记的单链核酸的特征在于荧光原子群对（荧光原子群对A）中的一个的发光峰值波长比另一个荧光原子群对（荧光原子群对B ），并且荧光原子群对A和B具有福斯特共振能量转移（FRET）效应。该荧光标记的单链核酸可用作扩增靶核酸或与靶核酸杂交的探针的引物。

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