专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1578993A2 METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE IL-4 RECEPTOR-MEDIATED IgE SYNTHESIS UTILIZING A B-CELL ASSOCIATED PROTEIN 审中-公开
标题翻译：一种用于识别THROUGH IGE调节性化合物的IL-4受体介导的合成使用带有B-ASSOCIATED蛋白质的细胞
公开(公告)号：EP1578993A2
公开(公告)日：2005-09-28
申请号：EP03764492.9
申请日：2003-07-10
申请人： Rigel Pharmaceuticals, Inc.
发明人： MASUDA, Esteban , KINSELLA, Todd, M. , WARNER, Justin, E. , KINOSHITA, Taisei , BENNETT, Mark, K. , ANDERSON, David, C.
IPC分类号： C12Q1/00
CPC分类号： G01N33/6869 , C07K7/08 , G01N33/5052 , G01N2500/20
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a BAP-37 as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

2. 发明授权

EP2443123B1 SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) 有权
标题翻译： KLEINMOLEKÜL-HEMMER DER SPLEEN-TYROSINKINASE
公开(公告)号：EP2443123B1
公开(公告)日：2017-04-05
申请号：EP10790003.7
申请日：2010-06-14
申请人： Rigel Pharmaceuticals, Inc.
发明人： ZHANG, Jing , SINGH, Rajinder , GOFF, Dane , KINOSHITA, Taisei
IPC分类号： C07D487/04 , C07D405/04 , A61K31/4162 , A61P37/02
CPC分类号： C07D487/04 , C07D405/04

3. 发明授权

EP2387565B1 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY DISORDERS 失效
标题翻译： 2.4 PYRIMIDINDIAMINVERBINDUNGEN炎症性疾病的治疗
公开(公告)号：EP2387565B1
公开(公告)日：2016-12-14
申请号：EP10732053.3
申请日：2010-01-13
申请人： Rigel Pharmaceuticals, Inc.
发明人： GURURAJA, Tarikere , PAYAN, Donald , TSO, Kin , KINOSHITA, Taisei , DING, Rongxian , SINGH, Rajinder , YUNG, Stephanie , LI, Hui , MASUDA, Esteban
IPC分类号： C07D239/32 , C07D239/30 , C07D403/12 , A61K31/495 , A61P29/00 , C07D451/04
CPC分类号： C07D451/04

4. 发明公开

EP2387402A2 METHODS FOR TREATING INFLAMMATORY DISORDERS USING 2,4-PYRIMIDINEDIAMINE COMPOUNDS 审中-公开
标题翻译：方法炎性疾病的与2,4- PYRIMIDINDIAMINVERBINDUNGEN于治疗
公开(公告)号：EP2387402A2
公开(公告)日：2011-11-23
申请号：EP10732052.5
申请日：2010-01-13
申请人： Rigel Pharmaceuticals, Inc.
发明人： LI, Hui , MASUDA, Esteban , YUNG, Stephanie , KINOSHITA, Taisei , DING, Rongxian , SINGH, Rajinder , GURURAJA, Tarikere , PAYAN, Donald , TSO, Kin
IPC分类号： A61K31/506 , A61K31/505 , A61P29/00
CPC分类号： A61K31/506

5. 发明公开

EP2443123A2 SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) 有权
标题翻译：脾酪氨酸激酶的小分子抑制剂
公开(公告)号：EP2443123A2
公开(公告)日：2012-04-25
申请号：EP10790003.7
申请日：2010-06-14
申请人： Rigel Pharmaceuticals, Inc.
发明人： ZHANG, Jing , SINGH, Rajinder , GOFF, Dane , KINOSHITA, Taisei
IPC分类号： C07D487/04 , C07D405/04 , A61K31/4162 , A61P37/02
CPC分类号： C07D487/04 , C07D405/04
摘要： This disclosure concerns compounds which are useful as inhibitors of spleen tyrosine kinase (Syk) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of Syk. This disclosure also relates to pharmaceutical compositions containing these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

6. 发明公开

EP1833807A1 UBIQUITIN LIGASE INHIBITORS 审中-公开
标题翻译：泛素连接酶抑制剂
公开(公告)号：EP1833807A1
公开(公告)日：2007-09-19
申请号：EP06717448.2
申请日：2006-01-05
申请人： Rigel Pharmaceuticals, Inc.
发明人： SINGH, Rajinder , RAMESH, Usha , ISSAKANI, Sarkiz, D. , HUANG, Jianing , KINOSHITA, Taisei , GURURAJA, Tarikere
IPC分类号： C07D277/42 , A61K31/426 , A61P35/00
CPC分类号： C07D277/38 , C07D277/42
摘要： This invention describes compounds and pharmaceutical compositions useful as ubiquitin agent inhibitors, particularly ubiquitin ligase inhibitors. The compounds and pharmaceutical compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved, such as signal transduction pathways. The invention also comprises the use of the compounds and pharmaceutical compositions of the invention for the treatment of conditions that require inhibition of ubiquitination. Furthermore, the invention comprises methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound or pharmaceutical composition according to the invention. Particularly, the compounds and pharmaceutical compositions are useful to inhibit the ubiquitin ligase activity of MDM2.
摘要翻译：本发明描述了用作泛蛋白剂抑制剂，特别是泛素连接酶抑制剂的化合物和药物组合物。本发明的化合物和药物组合物可用作涉及泛素化的生物体的生物化学途径的抑制剂，例如信号转导途径。本发明还包括本发明的化合物和药物组合物用于治疗需要抑制泛素化的病症的用途。此外，本发明包括抑制细胞中泛素化的方法，包括使需要抑制泛素化的细胞与本发明的化合物或药物组合物接触。特别地，所述化合物和药物组合物可用于抑制MDM2的泛素连接酶活性。

7. 发明公开

EP1551866A1 METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE IL-4 RECEPTOR-MEDIATED IGE SYNTHESIS UTILIZING A THIOREDOXIN-LIKE 32 KDA PROTEIN 审中-公开
标题翻译：用于鉴定化合物BY THE IL-4受体介导的IgE合成MODULATE，USING ATHIOREDOXINÄHNLICHEN32-kDa蛋白
公开(公告)号：EP1551866A1
公开(公告)日：2005-07-13
申请号：EP03764668.4
申请日：2003-07-14
申请人： Rigel Pharmaceuticals, Inc.
发明人： MASUDA, Esteban , KINSELLA, Todd, M. , WARNER, Justin, E. , KINOSHITA, Taisei , BENNETT, Mark, K. , ANDERSON, David,C.
IPC分类号： C07K7/00 , C07K14/00 , G01N33/53
CPC分类号： G01N33/6854 , A61K38/00
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a thioredoxin-like 32 kDa protein (TXNL) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

8. 发明公开

EP2387565A2 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY DISORDERS 失效
标题翻译： 2.4 PYRIMIDINDIAMINVERBINDUNGEN炎症性疾病的治疗
公开(公告)号：EP2387565A2
公开(公告)日：2011-11-23
申请号：EP10732053.3
申请日：2010-01-13
申请人： Rigel Pharmaceuticals, Inc.
发明人： GURURAJA, Tarikere , PAYAN, Donald , TSO, Kin , KINOSHITA, Taisei , DING, Rongxian , SINGH, Rajinder , YUNG, Stephanie , LI, Hui , MASUDA, Esteban
IPC分类号： C07D239/32 , C07D239/30 , C07D403/12 , A61K31/495 , A61P29/00
CPC分类号： C07D451/04
摘要： 2,4-Pyrimidinediamine compounds represented by formula (I), methods for preparing the same and methods for treating an inflammatory disorder and for inhibiting the production of IL-23 and/or stimulating the production of IL-10 using the same are disclosed.

9. 发明公开

EP1578931A2 METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE IL-4 RECEPTOR-MEDIATED IGE SYNTHESIS UTILIZING AN ADENOSINE KINASE 审中-公开
标题翻译：一种用于识别THROUGH IGE调节性化合物的IL-4受体介导的合成USING A腺苷激酶
公开(公告)号：EP1578931A2
公开(公告)日：2005-09-28
申请号：EP03764608.0
申请日：2003-07-15
申请人： Rigel Pharmaceuticals, Inc.
发明人： MASUDA, Esteban , KINSELLA, Todd, M. , WARNER, Justin, E. , KINOSHITA, Taisei , BENNETT, Mark, K. , ANDERSON, David, C.
IPC分类号： C12N1/00
CPC分类号： C12N9/1205 , A61K31/00 , A61K31/7076
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

10. 发明公开

EP1552309A2 METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE IL-4 RECEPTOR-MEDIATED IgE SYNTHESIS UTILIZING A CLLD8 PROTEIN 审中-公开
标题翻译：一种用于识别THROUGH IGE调节性化合物的IL-4受体介导的合成用蛋白质CLLD8
公开(公告)号：EP1552309A2
公开(公告)日：2005-07-13
申请号：EP03764436.6
申请日：2003-07-10
申请人： Rigel Pharmaceuticals, Inc.
发明人： MASUDA, Esteban , KINSELLA, Todd, M. , WARNER, Justin, E. , KINOSHITA, Taisei , BENNETT, Mark, K. , ANDERSON, David, C.
IPC分类号： G01N33/567 , G01N33/53 , C12Q1/52 , A61K38/00
CPC分类号： C07K7/08 , A61K38/1709 , C07K14/5406 , G01N33/6869 , G01N2333/5406 , G01N2500/00 , Y10S435/975
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式