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1. 发明公开

EP4271447A1 AUTO-INJECTOR AND RELATED METHODS OF USE 审中-实审
公开(公告)号：EP4271447A1
公开(公告)日：2023-11-08
申请号：EP21851923.9
申请日：2021-12-29
申请人： Regeneron Pharmaceuticals, Inc.
发明人： HALBIG, Daniel , GRYGUS, Bryan , LANGLEY, Trevor , DUMONT, Andrew , BURGESS, Bart, E. , PAUSLEY, Matthew , KENYON, Ross
IPC分类号： A61M5/142 , A61M5/145 , A61M5/20 , A61M5/24 , A61M5/31 , A61M5/315 , A61M5/32 , A61M39/24

2. 发明公开

EP3268078A1 ASEPTIC PIERCING SYSTEM AND METHOD 有权
标题翻译：无浆喷射系统和方法
公开(公告)号：EP3268078A1
公开(公告)日：2018-01-17
申请号：EP16713195.2
申请日：2016-03-10
申请人： Regeneron Pharmaceuticals, Inc.
发明人： ARNOTT, Rachel Paige , BURGESS, Bart E. , CUPICHA, Michael J. , GORALTCHOUK, Alexei , GRYGUS, Bryan , STELMAH, Mike
IPC分类号： A61M39/18 , A61M5/24
摘要： The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

4. 发明公开

EP3886946A1 DEVICES AND METHODS FOR PRECISION DOSE DELIVERY 审中-实审
公开(公告)号：EP3886946A1
公开(公告)日：2021-10-06
申请号：EP20747525.2
申请日：2020-06-04
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： ULLA, Sibgat , LANGLEY, Trevor , HALBIG, Daniel , GRYGUS, Bryan , SINGH, Prithvi , DUMONT, Andrew , BECHSTEIN, Justin , NETT, David , ODEGARD, Jeremy , GILLUM, Tasha , AINSWORTH, Ryan
IPC分类号： A61M5/31

5. 发明公开

EP3791919A1 ASEPTIC PIERCING SYSTEM 审中-实审
公开(公告)号：EP3791919A1
公开(公告)日：2021-03-17
申请号：EP20198799.7
申请日：2016-03-10
申请人： Regeneron Pharmaceuticals, Inc.
发明人： ARNOTT, Rachel Paige , BURGESS, Bart E. , CUPICHA, Michael J. , GORALTCHOUK, Alexei , GRYGUS, Bryan , STELMAH, Mike
IPC分类号： A61M39/18 , A61M5/24
摘要： The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

6. 发明公开

EP3626291A1 NEEDLE SHIELD GRIP DEVICE 审中-实审
公开(公告)号：EP3626291A1
公开(公告)日：2020-03-25
申请号：EP19194858.7
申请日：2019-09-02
申请人： Regeneron Pharmaceuticals, Inc.
发明人： GRYGUS, Bryan , GILDERSLEEVE, Richard Jeff , VARGHESE, Shaina
IPC分类号： A61M5/32
摘要： A needle guard grip device may include a body extending from a first end to a second end along a central longitudinal axis of the body. The body may include a plurality of ribs extending perpendicularly to the central longitudinal axis. The plurality of ribs may include a first set of longitudinally spaced ribs disposed on a first side of the central longitudinal axis, and a second set of longitudinally spaced ribs disposed on a second side of the central longitudinal axis that is opposite of the first side. Moving along the central longitudinal axis, ribs of the first set of longitudinally spaced ribs may alternate with ribs of the second set of longitudinally spaced ribs. The body may include an interior cavity extending from an opening in the first end of the body to a wall extending perpendicularly to the central longitudinal axis. One rib of the plurality of ribs may be positioned closer to the second end of the body than the wall. A first rib of the first set of longitudinally spaced ribs may include a convex external surface, and a second rib of the first set of longitudinal spaced ribs may include a concave external surface. Additionally, a retainer may be disposed within the interior cavity and may have a tab extending from a portion of the retainer closest to the first end of the body. The tab may extend toward the central longitudinal axis and at an angle to the central longitudinal axis.

7. 发明公开

EP4282451A2 DEVICES AND METHODS FOR PRECISION DOSE DELIVERY 审中-实审
公开(公告)号：EP4282451A2
公开(公告)日：2023-11-29
申请号：EP23196574.0
申请日：2018-12-12
申请人： Regeneron Pharmaceuticals, Inc.
发明人： ULLA, Sibgat , LAIACONA, Danielle , KENYON, Ross , LANGLEY, Trevor , GRYGUS, Bryan , HOUDE, Eric , MCNAMARA, Jeremy , VENUTO, Kathryn
IPC分类号： A61M5/31
摘要： Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening.
The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

8. 发明公开

EP4196060A1 SYSTEMS AND METHODS FOR DRUG DELIVERY TO OCULAR TISSUE 审中-实审
公开(公告)号：EP4196060A1
公开(公告)日：2023-06-21
申请号：EP21778690.4
申请日：2021-08-11
申请人： Regeneron Pharmaceuticals, Inc.
发明人： GRYGUS, Bryan , PAUSLEY, Matthew , DeRIDDER, Megan , WAECHTER, Paige , SINGH, Prithvi , KENYON, Ross , ULLA, Sibgat , LANGLEY, Trevor , IGLESIAS, Bibiana
IPC分类号： A61F9/00 , A61M5/46

9. 发明公开

EP3723828A1 DEVICES AND METHODS FOR PRECISION DOSE DELIVERY 有权
公开(公告)号：EP3723828A1
公开(公告)日：2020-10-21
申请号：EP18836978.9
申请日：2018-12-12
申请人： Regeneron Pharmaceuticals, Inc.
发明人： ULLA, Sibgat , LAIACONA, Danielle , KENYON, Ross , LANGLEY, Trevor , GRYGUS, Bryan , HOUDE, Eric , MCNAMARA, Jeremy , VENUTO, Kathryn
IPC分类号： A61M5/315 , A61M5/31

10. 发明公开

EP4282451A3 DEVICES AND METHODS FOR PRECISION DOSE DELIVERY 审中-实审
公开(公告)号：EP4282451A3
公开(公告)日：2024-02-21
申请号：EP23196574.0
申请日：2018-12-12
申请人： Regeneron Pharmaceuticals, Inc.
发明人： ULLA, Sibgat , LAIACONA, Danielle , KENYON, Ross , LANGLEY, Trevor , GRYGUS, Bryan , HOUDE, Eric , MCNAMARA, Jeremy , VENUTO, Kathryn
IPC分类号： A61M5/315 , A61M5/31
摘要： Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening.
The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

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