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2. 发明公开

EP3443984A1 PHARMACEUTICAL COMPOSITION FOR REDUCING THE SYMPTOMS AND DISEASE OF THE RESPIRATORY INFECTION CAUSED BY HUMAN METAPNEUMOVIRUS (HMPV), WHICH COMPRISES AT LEAST ONE AGENT THAT NEUTRALISES THE FUNCTION OF THE TSLP AND/OR TSLPR AND/OR OX40L AND/OR CD177 MOLECULES, AND A PHARMACEUTICALLY ACCEPTABLE EXCIPIENT, AND THE USE THEREOF 审中-公开
公开(公告)号：EP3443984A1
公开(公告)日：2019-02-20
申请号：EP16898537.2
申请日：2016-04-15
申请人： Pontificia Universidad Católica De Chile
发明人： KALERGIS PARRA, Alexis Mikes , LAY REMOLCOI, Margarita Kam-Lem , BUENO RAMIREZ, Susan Marcela
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28
摘要： The present invention relates to a pharmaceutical composition for ameliorating the symptoms and disease of the respiratory infection caused by human Metapneumovirus (hMPV), which comprises at least one agent that neutralizes the function of TSLP and/or TSLPR and/or OX40L and/or CD177 molecules, and a pharmaceutically acceptable excipient, wherein the agent is selected from monoclonal antibodies, biological or synthetic molecules. More specifically, the neutralizing agents are humanized anti-TSLP, anti-TSLPR, anti-OX40L and anti-CD 177 monoclonal antibodies. The use of said composition for preparing a medicament for treating or ameliorating the symptoms and disease of patients infected with human Metapneumovirus (hMPV) is also described.

3. 发明公开

EP3495386A1 SPECIFIC MONOCLONAL ANTIBODIES OF THE ANTIGEN M OF THE HUMAN METAPNEUMOVIRUS (HMPV) AND USE THEREOF IN A DIAGNOSTIC METHOD 审中-公开
公开(公告)号：EP3495386A1
公开(公告)日：2019-06-12
申请号：EP18188183.0
申请日：2015-02-02
申请人： Pontificia Universidad Católica De Chile
发明人： BUENO RAMÍREZ, Susan Marcela , KALERGIS PARRA, Alexis Mikes , MORA ALARCÓN, Jorge Eugenio
IPC分类号： C07K16/10 , G01N33/569
摘要： The invention relates to murine monoclonal antibodies corresponding to monoclonal antibodies secreted by cell lines of hybridomas denominated 3G8/C11 and 7G4/A12, and which react against the antigen M of hMPV. Said antibodies do not compete with each other for the binding site for binding to the antigen, nor do they impede the simultaneous binding thereof to the antigen. Said monoclonal antibodies can be used for tests for the detection, diagnosis and/or determination of infection by hMPV.

4. 发明公开

EP3328884A2 MONOCLONAL ANTIBODIES SPECIFICALLY FOR THE PHOSPHOPROTEIN OF THE HUMAN RESPIRATORY SYNCYTIAL VIRUS AND THE METHODS OF USE 有权
公开(公告)号：EP3328884A2
公开(公告)日：2018-06-06
申请号：EP16832387.1
申请日：2016-07-25
申请人： Pontificia Universidad Católica De Chile
发明人： BUENO RAMÍREZ, Susan Marcela , KALERGIS PARRA, Alexis Mikes , MORA ALARCÓN, Jorge Eugenio
IPC分类号： C07K16/10
摘要： The present invention refers to monoclonal antibodies or fragments thereof which are binding to the protein P of the human Respiratory Syncytial Virus (RSV) which comprise a variable region of the heavy chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or SEQ ID 5 or a variable region of the light chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No:2 or SEQ ID No: 6. The invention provides also diagnostic methods ex vivo or in vitro for detection of the viral antigen P of RSV, in which are used the monoclonal antibodies produced and secreted by the hybridomas 2E6/D2 and 6H5/H1. The invention can be used in detection for RSV kits, comprising the antibodies produced by the mentioned hybridomas.

5. 发明公开

EP3054013A1 IMMUNOGENIC FORMULATION CONTAINING RECOMBINANT LIVE BCG THAT EXPRESS ANTIGENS OF METAPNEUMOVIRUS (HMPV), IN A SUSPENSION PREPARED FROM A LYOPHILISATE, WITHOUT REQUIRING AN ADJUVANT, SUITABLE FOR PHARMACEUTICAL USE 有权
标题翻译：重组BCG活表达偏肺病毒抗原（hMPV的）的免疫原性制剂由粉末的悬浮液MANUFACTURED而不需要辅助物质用于药物用途
公开(公告)号：EP3054013A1
公开(公告)日：2016-08-10
申请号：EP14850538.1
申请日：2014-09-30
申请人： Pontificia Universidad Católica De Chile
发明人： BUENO RAMIREZ, Susan Marcela , KALERGIS PARRA, Alexis Mikes , PALAVECINO BEAUMONT, Christian
IPC分类号： C12N15/45
摘要： The present invention relates to an immunogenic formulation to be used in mammals against human Metapneumovirus (hMPV), consisting of a lyophilisate of 1x10 9 ufc/ml of recombinant BCG that expresses the viral protein P of hMPV (of genogroups A1, A2, B1 and B2). The vaccine is derived from the full or partial product of the P gene of hMPV, capable of being used, stabilised and administered in solution without requiring adjuvants. The preparation can also contain combinations of the aforementioned formulations. The formulation is stabilised by means of lyophilisation (conservation range of between 4°C and 8°C) in order to be subsequently reconstituted in an adjuvant-free saline solution prior to use.
摘要翻译：本发明涉及在以针对人偏肺病毒由...组成1×10 9 UFC / ml的重组BCG没有快车的hMPV的病毒蛋白P（基因型组的冻干物的哺乳动物（hMPV的）中使用的免疫原性制剂A1，A2，B1和 B2）。该疫苗是从肺病毒的P基因的全部或部分产物衍生，能够被使用，稳定，并在溶液中给药，而不需要佐剂。因此，该制剂可以含有上述式蒸发散的组合。制剂通过冷冻干燥的装置，以便随后被重构于上自由佐剂盐溶液在使用前（4℃和8℃之间保存范围）稳定。

6. 发明公开

EP2784088A2 MONOCLONAL ANTIBODIES SPECIFIC FOR THE M2-1 ANTIGEN OF RESPIRATORY SYNCYTIAL VIRUS (RSV) 有权
标题翻译： FÜRDAS M2-1抗生素抗生素SYNZYTIALVIRUS（RSV）SPEZIFISCHE MONOKLONALEANTIKÖRPER
公开(公告)号：EP2784088A2
公开(公告)日：2014-10-01
申请号：EP12851478.3
申请日：2012-11-23
申请人： Pontificia Universidad Católica de Chile
发明人： KALERGIS PARRA, Alexis Mikes , BUENO RAMIREZ, Susan Marcela , MORA ALARCON, Jorge Eugenio , GÓMEZ JOHNSON, Roberto Sebastián
IPC分类号： C07K16/08 , A61K39/395 , G01N33/53
CPC分类号： C07K16/1027 , C07K2317/20 , C07K2317/56 , G01N33/56983 , G01N2333/135
摘要： The present invention relates to the use of monoclonal antibodies specific for respiratory syncytial virus (RSV). Specifically, the invention relates to a monoclonal antibody IgG2A secreted by the cell line of 8A4/G9 hybridoma specifically directed to the M2-1 viral antigen, which is associated with the nucleocapside of the virus. The antibodies can be used for assays for the detection and/or determination of RSV infection. Said antibodies are in the pure state and do not contain any other contaminating biological material.
In another aspect of the invention a method for preventing and treating the infection caused by respiratory syncytial virus (RSV) in a given host is provided, comprising the administration of a composition containing the monoclonal antibodies secreted by the 8A4/G9 hybridoma in sufficient doses to prevent the disease. The antibody can be humanized in order to minimize the possibility of an immune response against the same in the patient.
In addition, the invention can be used to obtain any pharmaceutical form of the formulation of the monoclonal antibodies secreted by the 8A4/G9 hybridoma, which are suitable for the treatment or prevention of the disease caused by RSV.
The invention also provides methods for detection and diagnosis of RSV viral antigens in biological samples using the monoclonal antibodies produced and secreted by cells of the 8A4/G9 hybridoma.
摘要翻译：本发明涉及对呼吸道合胞病毒（RSV）特异性的单克隆抗体的应用。具体地，本发明涉及由特异性针对M2-1病毒抗原的与病毒核衣壳相关的8A4 / G9杂交瘤细胞系分泌的单克隆抗体IgG2A。抗体可用于检测和/或确定RSV感染的测定。所述抗体处于纯状态并且不含任何其它污染的生物材料。在本发明的另一方面，提供了用于预防和治疗在给定宿主中由呼吸道合胞病毒（RSV）引起的感染的方法，包括以足够的剂量施用含有由8A4 / G9杂交瘤分泌的单克隆抗体的组合物，预防疾病。抗体可以被人源化以便最小化对患者的免疫应答的可能性。此外，本发明可用于获得由8A4 / G9杂交瘤分泌的单克隆抗体制剂的任何药物形式，其适用于治疗或预防由RSV引起的疾病。本发明还提供了使用由8A4 / G9杂交瘤的细胞产生和分泌的单克隆抗体来检测和诊断生物样品中RSV病毒抗原的方法。

7. 发明公开

EP3904380A1 MONOCLONAL ANTIBODIES SPECIFIC FOR THE PB2 ANTIGEN OF THE HUMAN INFLUENZA VIRUS (FLU), NUCLEOTIDE SEQUENCES, METHOD AND DIAGNOSTIC KIT FOR FLU INFECTION 审中-公开
公开(公告)号：EP3904380A1
公开(公告)日：2021-11-03
申请号：EP19905189.7
申请日：2019-12-27
申请人： Pontificia Universidad Católica de Chile
发明人： KALERGIS PARRA, Alexis Mikes , BUENO RAMÍREZ, Susan Marcela
IPC分类号： C07K16/08 , C07K16/10 , G01N33/50 , G01N33/53
摘要： The invention discloses the generation of monoclonal antibodies, or fragments thereof, that recognize the PB2 protein of the human influenza virus (Flu), where said monoclonal antibodies or fragments thereof, comprise a heavy chain variable region and light chain variable region. Furthermore, a diagnostic method is provided to detect Flu infections in biological samples of nasopharyngeal secretions, using monoclonal antibodies in diagnostic kit format.

9. 发明公开

EP3406262A2 MONOCLONAL ANTIBODIES SPECIFIC FOR THE PIII ANTIGEN OF HUMAN ADENOVIRUS (ADV), PRODUCED AND SECRETED BY CELL HYBRIDOMAS, USEFUL FOR DETECTION AND DIAGNOSIS OF ADV INFECTION 有权
公开(公告)号：EP3406262A2
公开(公告)日：2018-11-28
申请号：EP17741167.5
申请日：2017-01-20
申请人： Pontificia Universidad Católica De Chile
发明人： BUENO RAMÍREZ, Susan Marcela , KALERGIS PARRA, Alexis Mikes , MORA ALARCÓN, Jorge Eugenio
IPC分类号： A61K39/395 , A61K39/235 , G01N33/569 , C07K16/08
CPC分类号： C07K16/081
摘要： The present invention refers to monoclonal antibodies, or fragments thereof, which recognize the pIII protein of the Adenovirus (ADV), useful for developing diagnostic methods of ADV infection in humans. Particularly, it refers to a monoclonal antibody or fragment thereof comprising a variable region of the heavy chain having a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or SEQ ID No: 5 and a variable region of the light chain having a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 2 or SEQ ID No: 6. It also is addressed to the nucleotide sequences which define said antibodies, in vitro and/or ex vivo diagnostic methods of ADV infection in a biological sample using said monoclonal antibodies, and diagnostic kits for detecting ADV comprising at least one monoclonal antibody against ADV according to the above description.

10. 发明公开

EP3904379A1 MONOCLONAL ANTIBODY OR ANTIGEN BINDING FRAGMENT THEREOF THAT BINDS TO THE L PROTEIN OF THE HUMAN PARAINFLUENZA VIRUS (PIV); METHOD AND KIT FOR DETECTING PIV 审中-实审
公开(公告)号：EP3904379A1
公开(公告)日：2021-11-03
申请号：EP19903462.0
申请日：2019-12-27
申请人： Pontificia Universidad Católica de Chile
发明人： KALERGIS PARRA, Alexis Mikes , BUENO RAMÍREZ, Susan Marcela
IPC分类号： C07K16/08 , C07K16/10 , G01N33/50 , G01N33/53
摘要： The invention disclose the generation of monoclonal antibodies, or fragments thereof, that recognize the human parainfluenza virus (PIV) chimeric protein L, where said monoclonal antibodies or fragments thereof comprise a heavy chain variable region and a light chain variable region. In addition, a method of diagnosing PIV infection in a biological sample of nasopharyngeal secretion is provided, using the monoclonal antibodies in diagnostic kit format.

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