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1. 发明公开

EP3201218A1 BETA-HAIRPIN PEPTIDOMIMETICS 有权
标题翻译： BETA-HAIRPIN多肽
公开(公告)号：EP3201218A1
公开(公告)日：2017-08-09
申请号：EP15778875.3
申请日：2015-09-29
申请人： Polyphor AG
发明人： OBRECHT, Daniel , LUTHER, Anatol , BERNARDINI, Francesca , DENIAU, Gildas , LEDERER, Alexander
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , Y02A50/473
摘要： Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
摘要翻译：通式（I）的β-发夹肽模拟物，环[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2]及其药学上可接受的盐与 P1至P12，T1和T2是说明书和权利要求书中定义的元素，对例如，具有Gramegative抗微生物活性抑制生长或杀死微生物如肺炎克雷伯氏菌和/或鲍曼不动杆菌和/或大肠杆菌。它们可以用作治疗或预防感染的药物，或用作食品，化妆品，药物或其他含营养物质的消毒剂。这些肽模拟物可以通过基于混合固相和液相合成策略的方法制造。

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