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1. 发明授权

EP2510357B1 MUTEINS OF HUMAN LIPOCALIN 2 (LCN2, HNGAL) WITH AFFINITY FOR A GIVEN TARGET 有权
标题翻译：具有亲和力的人脂蛋白2（LCN2，HNGAL）针对特定目标的突变
公开(公告)号：EP2510357B1
公开(公告)日：2016-03-30
申请号：EP10784824.4
申请日：2010-12-07
申请人： Pieris AG
发明人： SKERRA, Arne , GEBAUER, Michaela , HINZ, Dominik , RAUTH, Sabine , MATSCHINER, Gabriele , HUELSMEYER, Martin
IPC分类号： G01N33/566 , C07K1/00 , C07K14/775
CPC分类号： C07K14/47 , A61K38/00 , A61K38/1709 , A61K47/60 , C07K14/775 , C07K2319/30 , G01N33/566

2. 发明公开

EP2606061A1 BINDING PROTEINS FOR HEPCIDIN 有权
标题翻译： BINDUNGSPROTEINEFÜRHEPCIDIN
公开(公告)号：EP2606061A1
公开(公告)日：2013-06-26
申请号：EP11744024.8
申请日：2011-08-16
申请人： Pieris AG
发明人： TRENTMANN, Stefan , MATSCHINER, Gabriele , SKERRA, Arne , HUELSMEYER, Martin , GILLE, Hendrik , JENSEN, Kristian , BEL AIBA, Rachida Siham , CHRISTIAN, Hans-Juergen , HOHLBAUM, Andreas
IPC分类号： C07K14/435
CPC分类号： C07K14/47 , A61K38/00 , C07K14/435 , C07K16/26 , C07K2317/76 , C07K2317/92 , C07K2318/20
摘要： The present invention relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Hepcidin, which proteins preferably are muteins of a lipocalin protein. The invention also relates to nucleic acid molecules encoding such proteins and to methods for generation and use of such proteins and nucleic acid molecules. Accordingly, the invention also is directed to pharmaceutical and/or diagnostic compositions comprising such a lipocalin proteins, including uses of these proteins.
摘要翻译：本发明涉及针对Hepcidin的新型特异性结合的治疗和/或诊断蛋白质，该蛋白质优选为脂质运载蛋白的突变蛋白。本发明还涉及编码这种蛋白质的核酸分子以及用于产生和使用这些蛋白质和核酸分子的方法。因此，本发明还涉及包含这种脂质运载蛋白的药物和/或诊断组合物，包括这些蛋白质的用途。

3. 发明公开

EP2510357A2 MUTEINS OF HUMAN LIPOCALIN 2 (LCN2, HNGAL) WITH AFFINITY FOR A GIVEN TARGET 有权
标题翻译：具有亲和力FOR特定靶分子HUMAN脂质运载蛋白2的突变蛋白（LCN2，hNGAL）
公开(公告)号：EP2510357A2
公开(公告)日：2012-10-17
申请号：EP10784824.4
申请日：2010-12-07
申请人： Pieris AG
发明人： SKERRA, Arne , GEBAUER, Michaela , HINZ, Dominik , RAUTH, Sabine , MATSCHINER, Gabriele , HUELSMEYER, Martin
IPC分类号： G01N33/566 , C07K1/00 , C07K14/775
CPC分类号： C07K14/47 , A61K38/00 , A61K38/1709 , A61K47/60 , C07K14/775 , C07K2319/30 , G01N33/566
摘要： The present invention relates to a novel library for the generation of muteins and to novel muteins derived from human lipocalin 2 (Lcn2, hNGAL) and related proteins that bind a given target with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. For example, such muteins may serve to bind and deplete pathological forms of natural biomolecules such as the amyloid beta peptide in Alzheimer's disease or may target the fibronectin extra-domain B, which is associated with tumor neovasculature.

4. 发明公开

EP2046820A2 MUTEINS OF TEAR LIPOCALIN AND METHODS FOR OBTAINING THE SAME 有权
标题翻译： TEARLIPOCALIN和提取过程的突变蛋白FOR
公开(公告)号：EP2046820A2
公开(公告)日：2009-04-15
申请号：EP07788139.9
申请日：2007-08-01
申请人： Pieris AG
发明人： JENSEN, Kristian , HUELSMEYER, Martin , SCHLEHUBER, Steffen , HOHLBAUM, Andreas , SKERRA, Arne , BOUDREAU, Eric , JONES, Richard C. , KIMBER, Ian , DEARMAN, Rebecca
IPC分类号： C07K14/435
CPC分类号： A61K38/1709 , A61K38/38 , A61K47/60 , C07K14/435 , C07K14/47 , C07K14/705 , C12N5/10 , G01N33/57407 , G01N33/57492 , G01N2333/70521
摘要： The present invention relates to novel muteins derived from human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention further refers to a method for producing such a mutein. Finally, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.

5. 发明公开

EP2990798A1 MUTEINS OF HUMAN LIPOCALIN 2 (LCN2, HNGAL) WITH AFFINITY FOR A GIVEN TARGET 有权转让
标题翻译： MUTEINE VON HUMANEM LIPOCALIN 2（LCN2，HNGAL）MITAFFINITÄTFÜREIN BESTIMMTESZIELMOLEKÜL
公开(公告)号：EP2990798A1
公开(公告)日：2016-03-02
申请号：EP15186647.2
申请日：2010-12-07
申请人： Pieris AG
发明人： SKERRA, Arne , GEBAUER, Michaela , HINZ, Dominik , RAUTH, Sabine , MATSCHINER, Gabriele , HUELSMEYER, Martin
IPC分类号： G01N33/566 , C07K1/00 , C07K14/775
CPC分类号： C07K14/47 , A61K38/00 , A61K38/1709 , A61K47/60 , C07K14/775 , C07K2319/30 , G01N33/566
摘要： The present invention relates to a novel library for the generation of muteins and to novel muteins derived from human lipocalin 2 (Lcn2, hNGAL) and related proteins that bind a given target with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. For example, such muteins may serve to bind and deplete pathological forms of natural biomolecules such as the amyloid beta peptide in Alzheimer's disease or may target the fibronectin extra-domain B, which is associated with tumor neovasculature.
摘要翻译：本发明涉及用于产生突变蛋白的新文库和衍生自人脂质运载蛋白2（Lcn2，hNGAL）的新型突变蛋白以及以可检测的亲和力结合给定靶的相关蛋白。本发明还涉及编码这种突变蛋白的相应核酸分子及其产生方法。本发明还涉及一种制备这种突变蛋白的方法。例如，这种突变蛋白可用于结合和消耗天然生物分子的病理形式，例如阿尔茨海默病中的淀粉样蛋白β肽，或者靶向与肿瘤新血管生成相关的纤连蛋白结构域外结构域B.

6. 发明公开

EP2646552A1 MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR CTLA-4 有权转让
标题翻译： HUMAN脂质运载蛋白2与亲和力CTLA-4突变蛋白
公开(公告)号：EP2646552A1
公开(公告)日：2013-10-09
申请号：EP11802007.2
申请日：2011-12-02
申请人： Pieris AG
发明人： MATSCHINER, Gabriele , SKERRA, Arne , HOHLBAUM, Andreas
IPC分类号： C12N15/10 , C12N15/62 , A61K38/17 , C07K14/47
CPC分类号： C07K14/435 , C07K14/47 , C07K14/705 , C12N5/10 , G01N33/57407 , G01N33/57492 , G01N2333/70521
摘要： The present invention relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Cytotoxic T-Lymphocyte Antigen 4(CTLA-4) also known as CD152, which proteins preferably are muteins of a lipocalin protein, more preferably of lipocalin 2 (Lcn2 or NGAL). The invention also relates to nucleic acid molecules encoding such proteins and to methods for generation and use of such proteins and nucleic acid molecules. Accordingly, the invention also is directed to pharmaceutical and/or diagnostic compositions comprising such lipocalin proteins, including uses of these proteins.

7. 发明授权

EP2046820B1 MUTEINS OF TEAR LIPOCALIN AND METHODS FOR OBTAINING THE SAME 有权
标题翻译： TEARLIPOCALIN和提取过程的突变蛋白FOR
公开(公告)号：EP2046820B1
公开(公告)日：2010-10-20
申请号：EP07788139.9
申请日：2007-08-01
申请人： Pieris AG
发明人： JENSEN, Kristian , HUELSMEYER, Martin , SCHLEHUBER, Steffen , HOHLBAUM, Andreas , SKERRA, Arne , BOUDREAU, Eric , JONES, Richard C. , KIMBER, Ian , DEARMAN, Rebecca
IPC分类号： C07K14/435
CPC分类号： A61K38/1709 , A61K38/38 , A61K47/60 , C07K14/435 , C07K14/47 , C07K14/705 , C12N5/10 , G01N33/57407 , G01N33/57492 , G01N2333/70521

8. 发明授权

EP1660528B1 MUTEINS OF TEAR LIPOCALIN 有权转让
标题翻译：泪脂质运载蛋白的突变蛋白
公开(公告)号：EP1660528B1
公开(公告)日：2009-10-21
申请号：EP04764425.7
申请日：2004-08-24
申请人： Pieris AG
发明人： SKERRA, Arne , SCHLEHUBER, Steffen
IPC分类号： C07K14/47 , G01N33/573
CPC分类号： C07K14/47
摘要： The present invention relates to novel muteins derived from tear lipocalin or a homologue thereof. In particular, the invention relates to a mutein of human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention further refers to a method for producing such a mutein. Finally, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various use of the mutein.

9. 发明授权

EP2606061B1 BINDING PROTEINS FOR HEPCIDIN 有权
公开(公告)号：EP2606061B1
公开(公告)日：2017-08-09
申请号：EP11744024.8
申请日：2011-08-16
申请人： Pieris AG
发明人： TRENTMANN, Stefan , MATSCHINER, Gabriele , SKERRA, Arne , HUELSMEYER, Martin , GILLE, Hendrik , JENSEN, Kristian , BEL AIBA, Rachida Siham , CHRISTIAN, Hans-Juergen , HOHLBAUM, Andreas
IPC分类号： C07K14/435
CPC分类号： C07K14/47 , A61K38/00 , C07K14/435 , C07K16/26 , C07K2317/76 , C07K2317/92 , C07K2318/20
摘要： The present invention relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Hepcidin, which proteins preferably are muteins of a lipocalin protein. The invention also relates to nucleic acid molecules encoding such proteins and to methods for generation and use of such proteins and nucleic acid molecules. Accordingly, the invention also is directed to pharmaceutical and/or diagnostic compositions comprising such a lipocalin proteins, including uses of these proteins.

10. 发明公开

EP2614073A1 RECOMBINANT BACTERIAL LIPOCALIN BLC AND USES THEREOF 有权转让
标题翻译： REKOMBINANTES BAKTERIELLES LIPOCALIN BLC UND SEINE VERWENDUNG
公开(公告)号：EP2614073A1
公开(公告)日：2013-07-17
申请号：EP11754652.3
申请日：2011-09-07
申请人： Pieris AG
发明人： SKERRA, Arne , SCHIEFNER, André
IPC分类号： C07K14/245
CPC分类号： C07K14/245
摘要： The present inventors have solved the crystal structure of an Escherichia coli bacterial lipocalin polypeptide, which depicts a monomeric protein. Previous crystal structures have been reported, but these appear to be inaccurate, as they predicted, e.g., a dimeric protein. The crystal structure of a bacterial lipocalin provided by the present invention leads to numerous uses. For example, the present invention provides for the design, construction and use of recombinant libraries of diversified bacterial lipocalins resulting from a bacterial lipocalin polypeptide “backbone”.
摘要翻译：本发明人已经解决了描述单体蛋白质的大肠杆菌细菌脂质运载蛋白多肽的晶体结构。已经报道了以前的晶体结构，但是它们似乎是不精确的，如他们预测的那样，例如二聚体蛋白质。本发明提供的细菌脂质运载蛋白的晶体结构导致许多用途。例如，本发明提供了由细菌脂质运载蛋白多肽“骨架”产生的多种细菌脂质运载蛋白的重组文库的设计，构建和使用。

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