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1. 发明公开

EP2841590A4 NUCLEIC ACIDS, CELLS, AND METHODS FOR PRODUCING SECRETED PROTEINS 审中-公开
标题翻译： NUCLEIC，细胞及其制造方法的分泌蛋白
公开(公告)号：EP2841590A4
公开(公告)日：2016-03-23
申请号：EP13781040
申请日：2013-04-29
申请人： PRONUTRIA INC , GORA KATHERINE G , ROBICHON-IYER CARINE , SILVER NATHANIEL W , BERRY DAVID A
发明人： GORA KATHERINE G , ROBICHON-IYER CARINE , SILVER NATHANIEL W , BERRY DAVID A , GAOZHONG SHEN , YOUNG DAVID M , BASU SUBHAYU
IPC分类号： C12P21/06 , A23J1/00 , C07K14/195 , C07K14/405 , C12N1/20 , C12N15/74 , C12P21/00 , C12P21/02
CPC分类号： A23J1/009 , C07K14/195 , C07K14/405 , C07K2319/01 , C07K2319/036 , C12N9/2448 , C12N15/625 , C12P21/00 , C12P21/02

2. 发明公开

EP2831097A4 NUTRITIVE FRAGMENTS AND PROTEINS WITH LOW OR NO PHENYLALANINE AND METHODS 审中-公开
标题翻译： NÄHRSTOFFFRAGMENTEUND蛋白质麻醉剂NIEDRIGEM ODER KEINEM PHENYLALANINANTEIL UND VERFAHREN
公开(公告)号：EP2831097A4
公开(公告)日：2016-01-20
申请号：EP13767346
申请日：2013-03-15
申请人： PRONUTRIA INC
发明人： BERRY DAVID ARTHUR , BOGHIGIAN BRETT ADAM , SILVER NATHANIEL W , VON MALTZAHN GEOFFREY , CHILLAKURU RAJEEV , HAMILL MICHAEL J
IPC分类号： C07K14/435 , A23J3/04
CPC分类号： A23J1/008 , A23L33/17 , A23L33/195 , A23L33/30 , A23V2002/00 , C07K14/415 , C07K14/435 , C07K14/47 , A23V2200/316 , A23V2250/54

3. 发明公开

EP2922416A4 ENGINEERED SECRETED PROTEINS AND METHODS 审中-公开
标题翻译： VERFAHREN上的MANIPULIERTE SEKRETIERTE蛋白
公开(公告)号：EP2922416A4
公开(公告)日：2016-07-20
申请号：EP13856957
申请日：2013-11-20
申请人： PRONUTRIA INC
发明人： BASU SUBHAYU , GORA KATHERINE G , CHEN YING-JA , YOUNG DAVID M , SILVER NATHANIEL W , HAMILL MICHAEL , BERRY DAVID A
IPC分类号： C07K14/32 , A23L33/00 , A23L33/17 , A61K38/16 , C07K14/38
CPC分类号： C07K14/32 , A23L33/18 , A23L33/30 , A23V2002/00 , A61K38/16 , A61K38/1709 , C07K14/195 , C07K14/37 , C12N9/00 , C12N9/2428 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12P21/02
摘要： Nutritive proteins are provided herein. Also provided are various other embodiments including nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, vectors for expressing the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins. Nutritive proteins include engineered proteins, wherein the engineered proteins comprise a sequence of at least 20 amino acids that comprise an altered amino acid sequence compared to the amino acid sequence of a reference secreted protein and a ratio of essential amino acids to total amino acids present in the engineered protein higher than the ratio of essential amino acids to total amino acids present in the reference secreted protein. In some embodiments, the engineered protein comprises at least one essential amino acid residue substitution of a non-essential amino acid residue in the reference secreted protein.
摘要翻译：营养蛋白质在本文中提供。还提供了各种其它实施方案，包括编码蛋白质的核酸，制备蛋白质的重组微生物，用于表达蛋白质的载体，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物，以及使用蛋白质的方法。营养蛋白包括工程蛋白质，其中工程改造的蛋白质包含至少20个氨基酸的序列，其包含改变的氨基酸序列，与参考分泌蛋白质的氨基酸序列相比，必需氨基酸与总氨基酸的比例存在于工程蛋白高于参考分泌蛋白中存在的必需氨基酸与总氨基酸的比例。在一些实施方案中，工程改造的蛋白质包含参考分泌蛋白质中非必需氨基酸残基的至少一个必需氨基酸残基取代。

4. 发明公开

EP2831102A4 NUTRITIVE FRAGMENTS, PROTEINS AND METHODS 审中-公开
标题翻译： NÄHRMITTELFRAGMENTE，PROTEINE DAMIT UND VERFAHREN
公开(公告)号：EP2831102A4
公开(公告)日：2015-12-02
申请号：EP13770153
申请日：2013-03-15
申请人： PRONUTRIA INC
发明人： SILVER NATHANIEL W , BERRY DAVID ARTHUR , CHILLAKURU RAJEEV , VON MALTZAHN GEOFFREY , HAMILL MICHAEL J
IPC分类号： C07K14/435 , A23J3/04 , A23L1/305 , C12N1/21 , C12N15/63
CPC分类号： A23L33/18 , A23J3/04 , A23L1/293 , A23L33/17 , A23L33/30 , A23V2002/00 , A61K38/02 , A61K38/16 , C07K2/00 , C07K14/00 , C12N15/70 , C12P21/02
摘要： Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a protein digestibility corrected amino acid score (PDCAAS) that exceeds a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.
摘要翻译：提供营养蛋白质。在一些实施方案中，营养蛋白质包含超过基准蛋白质的蛋白质消化率校正的氨基酸分数（PDCAAS）。还提供了编码蛋白质的核酸，制备蛋白质的重组微生物，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物，以及使用蛋白质的方法等。

5. 发明公开

EP2831100A4 NUTRITIVE PROTEINS AND METHODS 审中-公开
标题翻译：营养蛋白和方法
公开(公告)号：EP2831100A4
公开(公告)日：2016-02-10
申请号：EP13768270
申请日：2013-03-15
申请人： PRONUTRIA INC
发明人： BERRY DAVID ARTHUR , BOGHIGIAN BRETT ADAM , SILVER NATHANIEL W , VON MALTZAHN GEOFFREY , CHILLAKURU RAJEEV , HAMILL MICHAEL J
IPC分类号： C07K14/435 , A23J3/04 , C12N15/12 , C12N15/63 , C12N15/74
CPC分类号： C07K14/415 , A23J3/04 , A23L33/175 , A23V2002/00 , A61K38/00 , C07K14/47
摘要： Nutritive proteins are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in whey protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in whey protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in whey protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.

6. 发明公开

EP2831099A4 NUTRITIVE FRAGMENTS, PROTEINS AND METHODS 无效转让
标题翻译： NÄHRMITTELFRAGMENTE，PROTEINE DAMIT UND VERFAHREN
公开(公告)号：EP2831099A4
公开(公告)日：2016-01-13
申请号：EP13768128
申请日：2013-03-15
申请人： PRONUTRIA INC
发明人： BERRY DAVID ARTHUR , BOGHIGIAN BRETT ADAM , SILVER NATHANIEL W , VON MALTZAHN GEOFFREY , CHILLAKURU RAJEEV , HAMILL MICHAEL J
IPC分类号： C07K14/435 , A23J3/04 , C12N1/21 , C12N15/63 , A23L1/305
CPC分类号： C07K14/435 , A23L33/17 , A23L33/18 , A23V2002/00 , A61K38/1709 , A23V2200/332 , A23V2250/54
摘要： Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. In some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein. In some embodiments, the fragment comprises at least one of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein, that is equal to or greater than the corresponding ratio present in a benchmark protein such as whey, egg or soy protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.
摘要翻译：提供营养蛋白质。在一些实施方案中，营养蛋白质包含包含天然存在的营养蛋白片段的第一多肽序列。在一些实施方案中，片段包含a）增强的分支链氨基酸残基与存在于营养蛋白中的总氨基酸残基的比例中的至少一个; b）营养蛋白中存在的亮氨酸残基与总氨基酸残基的比例增加; 和c）营养蛋白中存在的必需氨基酸残基与总氨基酸残基的比例增加。在一些实施方案中，片段包含以下至少一种：a）营养蛋白中存在的支链氨基酸残基与总氨基酸残基的比例; b）营养蛋白中存在的亮氨酸残基与总氨基酸残基的比例; 和c）营养蛋白中存在的必需氨基酸残基与总氨基酸残基的比例，等于或大于基准蛋白如乳清，蛋或大豆蛋白中存在的相应比例。还提供了编码蛋白质的核酸，制备蛋白质的重组微生物，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物，以及使用蛋白质的方法等。

7. 发明公开

EP2831101A4 CHARGED NUTRITIVE FRAGMENTS, PROTEINS AND METHODS 审中-公开
标题翻译：电荷碎片的营养，蛋白质和方法
公开(公告)号：EP2831101A4
公开(公告)日：2016-01-06
申请号：EP13770012
申请日：2013-03-15
申请人： PRONUTRIA INC
发明人： BERRY DAVID ARTHUR , BOGHIGIAN BRETT ADAM , SILVER NATHANIEL W , VON MALTZAHN GEOFFREY , CHILLAKURU RAJEEV , HAMILL MICHAEL J
IPC分类号： C07K14/435 , A23J3/04 , C12N1/21 , C12N15/63 , A23L1/305
CPC分类号： C07K14/47 , A23L33/17 , A23V2002/00 , A61K38/00 , C07K14/375 , C07K14/415 , C07K14/435 , A23V2200/332 , A23V2250/54
摘要： Charged nutritive proteins provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.

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