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1. 发明授权

EP0389699B1 Thiazolidinedione derivatives as hypoglycemic agents 失效
标题翻译：噻唑烷衍生物作为降血糖药。
公开(公告)号：EP0389699B1
公开(公告)日：1994-05-11
申请号：EP89303086.6
申请日：1989-03-29
申请人： PFIZER INC.
发明人： Clark, David Alan , Goldstein, Steven Wayne , Hulin, Bernard
IPC分类号： C07D417/12 , A61K31/425 , C07D417/14 , A61K31/44 , C07D277/20 , C07D277/34
CPC分类号： C07D263/44 , C07D417/12

2. 发明授权

EP0332331B1 Thiazolidinedione hypoglycemic agents 失效
标题翻译：低分子量噻唑烷二酮衍生物。
公开(公告)号：EP0332331B1
公开(公告)日：1994-02-09
申请号：EP89302012.3
申请日：1989-02-28
申请人： PFIZER INC.
发明人： Clark, David Alan , Goldstein, Steven Wayne , Holland, Gerald Fagan , Hulin, Bernard , Rizzi, James Patrick
IPC分类号： C07D277/34 , A61K31/425 , C07D417/06 , A61K31/44
CPC分类号： C07D417/06 , C07C311/21 , C07C323/22 , C07D213/50 , C07D277/34 , C07D417/10

3. 发明公开

EP0332331A3 Thiazolidinedione hypoglycemic agents 失效
标题翻译：噻唑烷二酮高分子化合物
公开(公告)号：EP0332331A3
公开(公告)日：1989-11-29
申请号：EP89302012.3
申请日：1989-02-28
申请人： PFIZER INC.
发明人： Clark, David Alan , Goldstein, Steven Wayne , Holland, Gerald Fagan , Hulin, Bernard , Rizzi, James Patrick
IPC分类号： C07D277/34 , A61K31/425 , C07D417/06 , A61K31/44
CPC分类号： C07D417/06 , C07C311/21 , C07C323/22 , C07D213/50 , C07D277/34 , C07D417/10
摘要： 57 Hypoglycemic thiazolidine-2,4-dione derivatives of the formula
wherein the dotted line represents a bond or no bond; A and B are each independently CH or N, with the proviso that when A or B is N, the other is CH; X is S, SO, S0 2 , CH 2 , CHOH or CO; n is 0 or 1; Y is CHR 1 or NR 2 , with the proviso that when n is 1 and Y is NR 2 , X is SO 2 or CO; Z is CHR 3 , CH 2 CH 2 , CH = CH, OCH 2 , SCH 2 , SOCH 2 or S0 2 CH 2 ; R, R 1 , R 2 and R 3 are each independently hydrogen or methyl; and X' and X 2 are each independently hydrogen, methyl, trifluoromethyl, phenyl, benzyl, hydroxy, methoxy, phenoxy, benzyloxy, bromo, chloro or fluoro; a pharmaceutically-acceptable cationic salt thereof; or a pharmaceutically-acceptable acid addition salt thereof when A or B is N.

4. 发明公开

EP0857725A1 (N-(pyridinylmethyl)-heterocyclic)-ylideneamine compounds as nicotinic acetylcholine receptor binding agents 失效
标题翻译：（N-（吡啶基甲基） - 杂合基） - 亚基]氨基 - 衍生物，尼古丁 - 乙酰胆碱 - 受精 - 内酰胺
公开(公告)号：EP0857725A1
公开(公告)日：1998-08-12
申请号：EP97309220.8
申请日：1997-11-17
申请人： PFIZER INC.
发明人： Dorff, Peter Hans , Goldstein, Steven Wayne , Jung, Stanley , Nagel, Arthur Adam
IPC分类号： C07D417/06 , C07D401/06 , C07D471/04 , A61K31/44
CPC分类号： C07D401/06 , C07D417/06 , C07D471/04
摘要： An (N-(pyridinylmethyl)-heterocyclic)ylideneamine compound of the formula
wherein R 3 , A, and B are as described below, and its pharmaceutically acceptable salts and prodrugs. Compounds of the formula I and their pharmaceutically acceptable salts and prodrugs are useful in the treatment of addictive disorders, such as the use of tobacco or other nicotine containing products, neurological and mental disorders such as senile dementia of the Alzheimer's type, Parkinson's disease, attentional hyperactivity disorder, anxiety, obesity, Tourette s Syndrome and ulcerative colitis.
摘要翻译：其中R 3，A和B如下所述的（N-（吡啶基甲基） - 杂环）亚基胺化合物及其药学上可接受的盐和前药。式I化合物及其药学上可接受的盐和前药可用于治疗成瘾性疾病，例如使用烟草或其他含有尼古丁的产品，神经和精神障碍，例如老年痴呆型老年痴呆，帕金森病，注意多动障碍，焦虑，肥胖，Tourette @ s综合征和溃疡性结肠炎。

5. 发明授权

EP0332332B1 Hypoglycemic thiazolidinedione derivatives 失效
标题翻译：高分子量的噻唑烷二酮衍生物
公开(公告)号：EP0332332B1
公开(公告)日：1993-03-31
申请号：EP89302017.2
申请日：1989-03-01
申请人： PFIZER INC.
发明人： Clark, David Alan , Hulin, Bernard , Goldstein, Steven Wayne
IPC分类号： C07D417/10 , A61K31/425 , C07D417/14 , C07D277/34 , C07D417/06 , A61K31/44
CPC分类号： C07D417/10 , C07D277/34 , C07D417/14 , C07F7/1856

6. 发明公开

EP0389699A1 Thiazolidinedione derivatives as hypoglycemic agents 失效
标题翻译：噻唑烷衍生物低分子量Mittel。
公开(公告)号：EP0389699A1
公开(公告)日：1990-10-03
申请号：EP89303086.6
申请日：1989-03-29
申请人： PFIZER INC.
发明人： Clark, David Alan , Goldstein, Steven Wayne , Hulin, Bernard
IPC分类号： C07D417/12 , A61K31/425 , C07D417/14 , A61K31/44 , C07D277/20 , C07D277/34
CPC分类号： C07D263/44 , C07D417/12
摘要： Hypoglycemic thiazolidine-2,4-dione derivatives of the formula
wherein the dotted line represents a bond or no bond;
V is -CH=CH-, -N=CH-, -CH=N-, S, O or NR;
W is S, SO, SO₂, SO₂NR¹, NR¹SO₂, CONR¹ or NR¹CO;
X is S, O, NR², -CH=N- or -N=CH;
Y is CH or N;
Z is hydrogen, (C₁-C₇)alkyl, (C₃-C₇)cycloalkyl, phenyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C₁-C₃)alkyl, trifluoromethyl, (C₁-C₃)alkoxy, fluoro, chloro or bromo;
Z¹ is hydrogen or (C₁-C₃)alkyl;
R, R¹ and R² are each independently hydrogen or (C₁-C₄); and
n is 1, 2 or 3;
a pharmaceutically acceptable cationic salt thereof; or
a pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen.
摘要翻译：式CHEM的低血糖噻唑烷-2,4-二酮衍生物，其中虚线表示键或无键; V是-CH = CH-，-N = CH-，-CH = N-，S，O或NR; W是S，SO，SO 2，SO 2 NR 1，NR 1 SO 2，CONR 1或NR 1 CO; X是S，O，NR 2，-CH = N-或-N = CH; Y是CH或N; Z是氢，（C 1 -C 7）烷基，（C 3 -C 7）环烷基，苯基，吡啶基，呋喃基，噻吩基或被相同或不同的基团（C 1 -C 3）烷基，三氟甲基，（C 1 -C 3） -C 3）烷氧基，氟，氯或溴; Z 1是氢或（C 1 -C 3）烷基; R 1，R 2和R 2各自独立地为氢或（C 1 -C 4）; n为1,2或3; 其药学上可接受的阳离子盐; 或其药学上可接受的酸加成盐时，化合物含有碱性氮。

7. 发明公开

EP0306251A3 Azolidinedione derivatives 失效
标题翻译：氮杂吲哚衍生物
公开(公告)号：EP0306251A3
公开(公告)日：1990-08-01
申请号：EP88307985.7
申请日：1988-08-30
申请人： PFIZER INC.
发明人： Goldstein, Steven Wayne , Sarges, Reinhard
IPC分类号： C07D491/20 , C07D495/20 , C07D498/20 , C07D513/20 , A61K31/435 , C07D491/04 , C07D495/04
CPC分类号： C07D491/04
摘要： A series of novel spiro-heteroazolones derived from a 2,3-dihydropyrano[2,3-b]pyridine ring system have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Typical member compounds include spiro-imides, spiro-oxazolidinediones, spiro-thiazolidinediones and spiroimidazolidinediones derived from the aforesaid ring system. (4'S)(2'R)-6'-Chloro-2',3'-dihydro-2'-methyl-spiro-[imidazolidine-4,4'-4'H-py- rano[2,3-b]pyridine]-2,5-dione represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided.

8. 发明授权

EP0857725B1 (N-(pyridinylmethyl)-heterocyclic)-ylideneamine compounds as nicotinic acetylcholine receptor binding agents 失效
标题翻译：（N-（吡啶基甲基） - 杂环）-ylidenamin衍生物作为烟碱乙酰胆碱受体的粘合剂
公开(公告)号：EP0857725B1
公开(公告)日：2001-07-25
申请号：EP97309220.8
申请日：1997-11-17
申请人： PFIZER INC.
发明人： Dorff, Peter Hans , Goldstein, Steven Wayne , Jung, Stanley , Nagel, Arthur Adam
IPC分类号： C07D417/06 , C07D401/06 , C07D471/04 , A61K31/44
CPC分类号： C07D401/06 , C07D417/06 , C07D471/04

9. 发明公开

EP0332332A1 Hypoglycemic thiazolidinedione derivatives 失效
标题翻译：低分子量噻唑烷二酮衍生物。
公开(公告)号：EP0332332A1
公开(公告)日：1989-09-13
申请号：EP89302017.2
申请日：1989-03-01
申请人： PFIZER INC.
发明人： Clark, David Alan , Hulin, Bernard , Goldstein, Steven Wayne
IPC分类号： C07D417/10 , A61K31/425 , C07D417/14 , C07D277/34 , C07D417/06 , A61K31/44
CPC分类号： C07D417/10 , C07D277/34 , C07D417/14 , C07F7/1856
摘要： Hypoglycemic thiazolidine-2,4-dione derivatives
wherein the dotted line represents a bond or no bond;
V is -CH=CH-, -N=CH-, -CH=N- or S;
W is CH₂, CHOH, CO, C=NOR or -CH=CH-;
X is S, O, NR¹, -CH=N- or -N=CH-;
Y is CH or N;
Z is hydrogen, (C₁-C₇)alkyl, (C₃-C₇)cycloalkyl, phenyl, naphthyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C₁-C₃)alkyl, trifluoromethyl, (C₁-C₃)alkoxy, fluoro, chloro or bromo;
Z¹ is hydrogen or (C₁-C₃)alkyl;
R is hydrogen or methyl; and
n is 1, 2 or 3;
a pharmaceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen.
摘要翻译：低血糖噻唑烷-2,4-二酮衍生物其中虚线表示键或无键; V是-CH = CH-，-N = CH-，-CH = N-或S; W是CH 2，CHOH，CO，C = NOR或-CH = CH-; X是S，O，NR 1，-CH = N-或-N = CH-; Y是CH或N; Z是氢，（C 1 -C 7）烷基，（C 3 -C 7）环烷基，苯基，萘基，吡啶基，呋喃基，噻吩基或被相同或不同的基团（C 1 -C 3）烷基，（C 1 -C 3）烷氧基，氟，氯或溴; Z 1是氢或（C 1 -C 3）烷基; R是氢或甲基; n为1,2或3; 其药学上可接受的阳离子盐; 或其药学上可接受的酸加成盐时，化合物含有碱性氮。

10. 发明公开

EP0332331A2 Thiazolidinedione hypoglycemic agents 失效
标题翻译：低分子量噻唑烷二酮衍生物。
公开(公告)号：EP0332331A2
公开(公告)日：1989-09-13
申请号：EP89302012.3
申请日：1989-02-28
申请人： PFIZER INC.
发明人： Clark, David Alan , Goldstein, Steven Wayne , Holland, Gerald Fagan , Hulin, Bernard , Rizzi, James Patrick
IPC分类号： C07D277/34 , A61K31/425 , C07D417/06 , A61K31/44
CPC分类号： C07D417/06 , C07C311/21 , C07C323/22 , C07D213/50 , C07D277/34 , C07D417/10
摘要： 57 Hypoglycemic thiazolidine-2,4-dione derivatives of the formula

wherein the dotted line represents a bond or no bond;
A and B are each independently CH or N, with the proviso that when A or B is N, the other is CH;
X is S, SO, S0 2 , CH 2 , CHOH or CO;
n is 0 or 1;
Y is CHR 1 or NR 2 , with the proviso that when n is 1 and Y is NR 2 , X is SO 2 or CO;
Z is CHR 3 , CH 2 CH 2 , CH = CH,

OCH 2 , SCH 2 , SOCH 2 or S0 2 CH 2 ;
R, R 1 , R 2 and R 3 are each independently hydrogen or methyl; and
X' and X 2 are each independently hydrogen, methyl, trifluoromethyl, phenyl, benzyl, hydroxy, methoxy, phenoxy, benzyloxy, bromo, chloro or fluoro; a pharmaceutically-acceptable cationic salt thereof; or a pharmaceutically-acceptable acid addition salt thereof when A or B is N.
摘要翻译：式CHEM的低血糖噻唑烷-2,4-二酮衍生物，其中虚线表示键或无键; A和B各自独立地为CH或N，条件是当A或B为N时，另一个为CH; X是S，SO，SO 2，CH 2，CHOH或CO; n为0或1; Y是CHR 1或NR 2，条件是当n是1且Y是NR 2时，X是SO 2或CO; Z是CHR 3，CH 2 CH 2，CH = CH，CH 2 OCH 2，SCH 2，SOCH 2或SO 2 CH 2; R 1，R 2，R 2和R 3各自独立地为氢或甲基; X 1和X 2各自独立地为氢，甲基，三氟甲基，苯基，苄基，羟基，甲氧基，苯氧基，苄氧基，溴，氯或氟; 其药学上可接受的阳离子盐; 或当A或B为N时，其药学上可接受的酸加成盐。

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