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1. 发明公开

EP2807487A1 METHOD OF DETECTING TUBERCULOSIS 有权
标题翻译：检测方法的结核
公开(公告)号：EP2807487A1
公开(公告)日：2014-12-03
申请号：EP13740630.2
申请日：2013-01-25
申请人： PEAS Institut AB
发明人： NAYERI, Fariba
IPC分类号： G01N33/569 , C12Q1/04 , C07K16/12
CPC分类号： C12Q1/04 , C07K16/1289 , G01N33/5695
摘要： The present invention relates to a method for determining whether an individual has an active tuberculosis infection, a latent tuberculosis infection or is vaccinated against a tuberculosis infection or being healthy. The method comprises contacting a body fluid sample from an individual with an antibody having specificity for a Mycobacterium tuberculosis (Mtb) protein mimicking a human protein and studying the interaction between the protein in the sample and the antibody. High levels of proteins interacting with the antibody are indicative of an active Mtb infection and low levels of proteins interacting with the antibody are indicative of a latent Mtb infection. No levels of proteins interacting with the antibody are indicative of a vaccinated or healthy individual. The present invention also relates to a method determining whether the individual has a tuberculosis infection and to a method for detecting the potency of a vaccination against tuberculosis by contacting a sample from the individual with an antibody having a specificity for the Mtb or the BCG vaccine respectively and studying the interaction between the sample and the specific antibody.

2. 发明公开

EP1810037A1 ASSESSMENT OF BIOLOGICAL ACTIVITY OF HEPATOCYTE GROWTH FACTOR (HGF) 有权
标题翻译：评价HGF的生物活性（肝细胞生长因子）
公开(公告)号：EP1810037A1
公开(公告)日：2007-07-25
申请号：EP05797120.2
申请日：2005-10-20
申请人： PEAS Institut AB
发明人： NAYERI, Fariba
IPC分类号： G01N33/74
CPC分类号： G01N33/74 , G01N2333/4753
摘要： In the present invention the methods for recognition of biologically active hepatocyte growth factor efficient for using in therapeutic components are presented. The biological activity can be determined using: i) an in vitro model of restitution of damaged cells, and/or ii) affinity measurements or epitope mapping using SPR, with the C-met receptor, ant i -HGF antibodies or polysaccharides such as dextran, and/or iii) .an animal model of hair growth rates. By these methods the activity of HGF in body secretions can be evaluated as well .

3. 发明授权

EP1810037B1 ASSESSMENT OF BIOLOGICAL ACTIVITY OF HEPATOCYTE GROWTH FACTOR (HGF) 有权
标题翻译：评价HGF的生物活性（肝细胞生长因子）
公开(公告)号：EP1810037B1
公开(公告)日：2010-07-21
申请号：EP05797120.2
申请日：2005-10-20
申请人： PEAS Institut AB
发明人： NAYERI, Fariba
IPC分类号： G01N33/74
CPC分类号： G01N33/74 , G01N2333/4753

4. 发明公开

EP3532849A1 DEVICE AND METHOD FOR DETECTING A BACTERIAL INFECTION 有权
公开(公告)号：EP3532849A1
公开(公告)日：2019-09-04
申请号：EP17801361.1
申请日：2017-10-31
申请人： PEAS Institut AB
发明人： NAYERI, Fariba
IPC分类号： G01N33/569 , G01N33/543 , G01N33/68

5. 发明授权

EP2807487B1 METHOD OF DETECTING TUBERCULOSIS 有权
标题翻译：检测结核的方法
公开(公告)号：EP2807487B1
公开(公告)日：2017-11-29
申请号：EP13740630.2
申请日：2013-01-25
申请人： PEAS Institut AB
发明人： NAYERI, Fariba
IPC分类号： G01N33/569 , C12Q1/04 , C07K16/12
CPC分类号： C12Q1/04 , C07K16/1289 , G01N33/5695
摘要： The present invention relates to a method for determining whether an individual has an active tuberculosis infection, a latent tuberculosis infection or is vaccinated against a tuberculosis infection or being healthy. The method comprises contacting a body fluid sample from an individual with an antibody having specificity for a Mycobacterium tuberculosis (Mtb) protein mimicking a human protein and studying the interaction between the protein in the sample and the antibody. High levels of proteins interacting with the antibody are indicative of an active Mtb infection and low levels of proteins interacting with the antibody are indicative of a latent Mtb infection. No levels of proteins interacting with the antibody are indicative of a vaccinated or healthy individual. The present invention also relates to a method determining whether the individual has a tuberculosis infection and to a method for detecting the potency of a vaccination against tuberculosis by contacting a sample from the individual with an antibody having a specificity for the Mtb or the BCG vaccine respectively and studying the interaction between the sample and the specific antibody.

6. 发明公开

EP2817636A1 NEW METHOD FOR RAPID DETECTION OF HEPATOCYTE GROWTH FACTOR IN BIOLOGICAL FLUIDS 审中-公开
标题翻译：新方法肝细胞生物体液中快速检测
公开(公告)号：EP2817636A1
公开(公告)日：2014-12-31
申请号：EP13751847.8
申请日：2013-02-22
申请人： PEAS Institut AB
发明人： NAYERI, Fariba , BAHAR, Kamal
IPC分类号： G01N33/74
CPC分类号： G01N33/74 , G01N33/52 , G01N2333/4753
摘要： The present invention relates to a method for determining the presence, absence or amount of biologically active HGF in a sample, comprising the steps (i) bringing the sample in contact with a first porous solid phase comprising a HGF binding component of the extracellular matrix or cell membrane, and an indicator composition comprising bromothymol blue and a quaternary ammonium compound; and (ii) correlating the colour of the porous solid phase with the presence, absence or amount of biologically active HGF in the sample. It further relates to a device comprising a first porous solid phase comprising at least one HGF-binding component of the extracellular matrix or cell membrane, and an indicator composition comprising bromothymol blue and a quaternary ammonium compound.

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