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1. 发明授权

EP3177926B1 LATERAL-FLOW ASSAY DEVICE HAVING FLOW CONSTRICTIONS 有权
公开(公告)号：EP3177926B1
公开(公告)日：2018-06-06
申请号：EP15750889.6
申请日：2015-08-05
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： DING, Zhong , SCALICE, Edward R. , SALOTTO, Daniel P.
IPC分类号： G01N33/543
CPC分类号： B01L3/5023 , B01L2300/041 , B01L2300/0867 , B01L2300/161 , B01L2400/0406 , G01N33/54386
摘要： A lateral-flow assay device includes a substrate having a sample addition zone and a wash addition zone downstream thereof along a fluid flow path through which a sample flows. The fluid flow path is configured to receive a wash fluid in the wash addition zone. A hydrophilic surface is arranged in the wash addition zone. Flow constriction(s) are spaced apart from the fluid flow path and arranged to define, with the hydrophilic surface, a reservoir configured to retain the wash fluid by formation of a meniscus between the hydrophilic surface and the flow constriction(s). The fluid flow path draws the wash fluid from the reservoir by capillary pressure. Apparatus for analyzing a fluidic sample and methods of displacing a fluidic sample in a fluid flow path of an assay device are also described.

2. 发明公开

EP3177926A1 LATERAL-FLOW ASSAY DEVICE HAVING FLOW CONSTRICTIONS 有权
标题翻译：侧向流量测定 - 麻醉麻醉剂DURCHFLUSSBESCHRÄNKUNGEN
公开(公告)号：EP3177926A1
公开(公告)日：2017-06-14
申请号：EP15750889.6
申请日：2015-08-05
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： DING, Zhong , SCALICE, Edward R. , SALOTTO, Daniel P.
IPC分类号： G01N33/543
CPC分类号： B01L3/5023 , B01L2300/041 , B01L2300/0867 , B01L2300/161 , B01L2400/0406 , G01N33/54386
摘要： A lateral-flow assay device includes a substrate having a sample addition zone and a wash addition zone downstream thereof along a fluid flow path through which a sample flows. The fluid flow path is configured to receive a wash fluid in the wash addition zone. A hydrophilic surface is arranged in the wash addition zone. Flow constriction(s) are spaced apart from the fluid flow path and arranged to define, with the hydrophilic surface, a reservoir configured to retain the wash fluid by formation of a meniscus between the hydrophilic surface and the flow constriction(s). The fluid flow path draws the wash fluid from the reservoir by capillary pressure. Apparatus for analyzing a fluidic sample and methods of displacing a fluidic sample in a fluid flow path of an assay device are also described.
摘要翻译：侧流测定装置包括沿样品流过的流体流动路径在其下游具有样品添加区和洗涤添加区的基底。流体流动路径构造成在洗涤添加区域中接收洗涤流体。亲水表面布置在洗涤添加区中。流动收缩部与流体流动路径间隔开并且布置成与亲水表面一起限定构造成通过在亲水表面和流动收缩部之间形成弯液面来保持洗涤流体的储存器。流体流动路径通过毛细管压力从储存器吸取洗涤流体。还描述了用于分析流体样品的装置和在测定装置的流体流动路径中移动流体样品的方法。

3. 发明授权

EP3194965B1 LATERAL FLOW ASSAY DEVICE 有权
公开(公告)号：EP3194965B1
公开(公告)日：2018-09-26
申请号：EP15753804.2
申请日：2015-08-07
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： DING, Zhong , HOSIMER, Philip C. , SCALICE, Edward R. , SALOTTO, Daniel P. , HEAVNER, David A.
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , B01L3/50 , G01N21/77 , G01N33/5306 , G01N33/536 , G01N33/54366 , G01N2021/7763
摘要： A lateral flow assay device includes a substrate having a top surface, as well as a sample receiving area disposed upon the top surface. At least one fluid flow path extends along the substrate from the sample receiving area, wherein the sample receiving area can be placed in contact with a peripheral reservoir formed at a sample addition area to draw sample therefrom in a controlled manner. The device can further include a reagent area that is designed to promote uniform dissolution of a deposited detection material by a sample moved through the device along the fluid flow path as well, as a flow channel configure to promote mixing of sample and reagent and an absorbing or wicking zone configured to affect various flow characteristics.

4. 发明公开

EP3194965A1 LATERAL FLOW ASSAY DEVICE 有权
标题翻译：横向流动测定装置
公开(公告)号：EP3194965A1
公开(公告)日：2017-07-26
申请号：EP15753804.2
申请日：2015-08-07
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： DING, Zhong , HOSIMER, Philip C. , SCALICE, Edward R. , SALOTTO, Daniel P. , HEAVNER, David A.
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N21/77 , G01N33/5306 , G01N33/536 , G01N33/54366 , G01N2021/7763
摘要： A lateral flow assay device includes a substrate having a top surface, as well as a sample receiving area disposed upon the top surface. At least one fluid flow path extends along the substrate from the sample receiving area, wherein the sample receiving area can be placed in contact with a peripheral reservoir formed at a sample addition area to draw sample therefrom in a controlled manner. The device can further include a reagent area that is designed to promote uniform dissolution of a deposited detection material by a sample moved through the device along the fluid flow path as well, as a flow channel configure to promote mixing of sample and reagent and an absorbing or wicking zone configured to affect various flow characteristics.
摘要翻译：侧流测定装置包括具有顶表面的基底以及设置在顶表面上的样品接收区域。至少一个流体流动路径沿着基板从样品接收区域延伸，其中样品接收区域可以被放置成与在样品添加区域处形成的外围储存器接触，以受控方式从中抽取样品。该装置可以进一步包括试剂区域，该试剂区域被设计为通过沿着流体流动路径移动通过该装置的样本促进沉积的检测材料的均匀溶解，作为构造成促进样本和试剂混合的流动通道和吸收剂或芯吸区配置为影响各种流动特性。

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