专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明公开

EP2968546A2 METHODS OF GENERATING BIOACTIVE PEPTIDE-BEARING ANTIBODIES AND COMPOSITIONS COMPRISING THE SAME 有权
标题翻译：生成含有活性肽的抗体的方法和包含该抗体的组合物
公开(公告)号：EP2968546A2
公开(公告)日：2016-01-20
申请号：EP14764165.8
申请日：2014-03-14
申请人： Omeros Corporation
发明人： CUMMINGS, W., Jason , GRAY, Patrick , TJOELKER, Larry, W. , YABUKI, Munehisa
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/811 , C07K16/00 , C07K2317/21 , C07K2317/23 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2318/10 , C07K2319/00 , C07K2319/30
摘要： In one aspect, the invention provides an isolated antibody, or antigen-binding fragment thereof, comprising a bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence is an inhibitor of the complement system and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region; or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation.
摘要翻译：一方面，本发明提供了包含生物活性肽氨基酸序列的分离的抗体或其抗原结合片段，其中所述生物活性肽氨基酸序列是补体系统的抑制剂并且融合至以下至少一种： i）至少以下之一的氨基末端区：轻链可变区和/或重链可变区; 或（ii）轻链恒定区和/或重链恒定区中的至少一个的羧基末端区，其中所述抗体抑制补体激活。

3. 发明公开

EP2742067A2 ANTI-FZD10 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE 审中-公开
标题翻译：单克隆抗体FZD10及使用方法
公开(公告)号：EP2742067A2
公开(公告)日：2014-06-18
申请号：EP12824632.9
申请日：2012-08-09
申请人： Omeros Corporation
发明人： CUMMINGS, W., Jason , YABUKI, Munehisa , LEPPARD, John, Benjamin , WOOD, Christi, L. , MAIZELS, Nancy , ALLISON, Daniel, S. , TJOELKER, Larry, W.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2896 , A61K39/39558 , A61K45/06 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/30 , C07K2317/23 , C07K2317/24 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates generally to anti-FZD10 antibodies and to methods of using anti-FZD10 antibodies. In particular, the anti-FZD10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of FZD10, including as stand-alone therapies and in combination therapies with other agents.

4. 发明授权

EP2825652B1 COMPOSITION AND METHOD FOR DIVERSIFICATION OF TARGET SEQUENCES 有权
公开(公告)号：EP2825652B1
公开(公告)日：2018-09-05
申请号：EP13761578.7
申请日：2013-03-13
申请人： Omeros Corporation , University of Washington through its Center for Commercialization
发明人： CUMMINGS, W., Jason , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa , ALLISON, Daniel, S. , LEPPARD, John, B. , MAIZELS, Nancy
IPC分类号： C12N15/63 , C12N15/13 , C12N15/70 , C12N15/79
CPC分类号： C12N15/1082 , C07K16/00 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/92
摘要： The disclosure relates generally to the targeting of genes to, and their integration into, an immunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged VH-D-JH genes of chicken, in a system for generating immunoglobulin diversity. Also contemplated is replacement of the chicken VH-D-JH with rearranged VH-D-JH genes of other vertebrates including human in a system for generating immunoglobulin diversity, with the exception of any substitution disclosed and claimed in PCT application WO 2009/029315 A2. Also described is construction of a diverse chicken immunoglobulin heavy chain VDJ library in DT40 by homologous gene replacement of the single endogenous rearranged VDJ gene with a chicken VDJ repertoire using the described targeting vectors.

5. 发明公开

EP2683740A2 GENERATION OF ANTI-FN14 MONOCLONAL ANTIBODIES BY EX-VIVO ACCELERATED ANTIBODY EVOLUTION 有权
标题翻译：生产单克隆抗FN14抗体通过离体加速抗体发生
公开(公告)号：EP2683740A2
公开(公告)日：2014-01-15
申请号：EP12754203.3
申请日：2012-03-09
申请人： Omeros Corporation
发明人： LEPPARD, John, Benjamin , WOOD, Christi, L. , CUMMINGS, W., Jason , YABUKI, Munehisa , MAIZELS, Nancy , ALLISON, Daniel, S. , TJOELKER, Larry, W.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/30 , C07K16/2878 , C07K2317/14 , C07K2317/23 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/77 , C07K2317/92 , C07K2319/55
摘要： The present invention relates generally to anti-FN14 antibodies. In particular, the anti-FN14 antibodies described herein are useful for the treatment of diseases, such as a variety of cancers, associated with expression of FN14.

6. 发明授权

EP2683740B1 GENERATION OF ANTI-FN14 MONOCLONAL ANTIBODIES BY EX-VIVO ACCELERATED ANTIBODY EVOLUTION 有权
公开(公告)号：EP2683740B1
公开(公告)日：2018-07-04
申请号：EP12754203.3
申请日：2012-03-09
申请人： Omeros Corporation
发明人： LEPPARD, John, Benjamin , WOOD, Christi, L. , CUMMINGS, W., Jason , YABUKI, Munehisa , MAIZELS, Nancy , ALLISON, Daniel, S. , TJOELKER, Larry, W.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C07K16/30
CPC分类号： C07K16/30 , C07K16/2878 , C07K2317/14 , C07K2317/23 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/77 , C07K2317/92 , C07K2319/55
摘要： The present invention relates generally to anti-FN14 antibodies. In particular, the anti-FN14 antibodies described herein are useful for the treatment of diseases, such as a variety of cancers, associated with expression of FN14.

7. 发明公开

EP2825652A1 COMPOSITION AND METHOD FOR DIVERSIFICATION OF TARGET SEQUENCES 有权
标题翻译：目标序列多样性的组成和方法
公开(公告)号：EP2825652A1
公开(公告)日：2015-01-21
申请号：EP13761578.7
申请日：2013-03-13
申请人： Omeros Corporation , University Of Washington Through Its Center For Commercialization
发明人： CUMMINGS, W., Jason , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa , ALLISON, Daniel, S. , LEPPARD, John, B. , MAIZELS, Nancy
IPC分类号： C12N15/63 , C12N15/13 , C12N15/70 , C12N15/79
CPC分类号： C12N15/1082 , C07K16/00 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/92
摘要： The disclosure relates generally to the targeting of genes to, and their integration into, an innnnunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged V
H -D-J
H genes of chicken, in a system for generating immunoglobulin diversity. Also contemplated is replacement of the chicken V
H -D-J
H with rearranged V
H -D-J
H genes of other vertebrates including human in a system for generating immunoglobulin diversity, with the exception of any substitution disclosed and claimed in PCT application WO 2009/029315 A2. Regions upstream of the rearranged V
H gene, and downstream of the rearranged J
H genes, are identified and incorporated into the immunoglobulin heavy chain gene-targeting vectors for efficient gene replacement. Also described is construction of a diverse chicken immunoglobulin heavy chain VDJ library in DT40 by homologous gene replacement of the single endogenous rearranged VDJ gene with a chicken VDJ repertoire using the described targeting vectors. The methods are useful for generating a diverse library of immunoglobulins that can be screened for binding to desired target antigens. Compositions include the unique targeting vectors, the diverse chicken heavy chain VDJ library in the targeting vectors, and the diverse chicken VDJ DT40 library that is created by homologous gene replacement of the single endogenous rearranged VDJ gene with a chicken VDJ repertoire, using the targeting vectors.
摘要翻译：本公开内容一般涉及基因靶向以及它们整合入免疫球蛋白（抗体）重链基因座。具体而言，本文所述的方法考虑在用于产生免疫球蛋白多样性的系统中用鸡的独立重排的V H-D-J H基因置换B细胞淋巴瘤例如DT40的单重排的重链V，D和J基因。除了在PCT申请WO 2009/029315 A2中公开并要求保护的任何替代之外，还考虑用在用于产生免疫球蛋白多样性的系统中的其他脊椎动物包括人的重排V H -D-J H基因置换鸡V H-D-J H。重排的V H基因的上游区域和重排的J H基因的下游区域被鉴定并掺入到免疫球蛋白重链基因靶向载体中用于有效的基因置换。还描述了在DT40中构建多样的鸡免疫球蛋白重链VDJ文库，其通过使用所述靶向载体用鸡VDJ库同源基因置换单一内源重排VDJ基因。该方法可用于产生可筛选与所需靶抗原结合的免疫球蛋白的多样文库。组合物包括独特的靶向载体，靶向载体中的不同鸡重链VDJ文库和通过用鸡VDJ库同源基因替换单一内源重排VDJ基因产生的不同鸡VDJ DT40文库，使用靶向载体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式