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1. 发明公开

EP3118211A8 AMIDE COMPOUNDS AND METHODS FOR THE PRODUCTION AND USE THEREOF 有权转让
标题翻译：酰胺化合物及其生产和使用方法
公开(公告)号：EP3118211A8
公开(公告)日：2017-09-06
申请号：EP15761359.7
申请日：2015-02-27
申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
发明人： NEBOLSIN, Vladimir Evgenievich , KROMOVA, Tatyana Alexandrovna
IPC分类号： C07K5/06 , C07K5/037 , A61K38/05 , A61P31/12 , A61P31/14 , A61P31/20 , A61P31/04 , A61P27/02 , A61P11/00 , A61P11/06 , A61P1/04 , A61P1/16
CPC分类号： C07D265/30 , A61K38/00 , C07D207/09 , C07D211/26 , C07D233/24 , C07D237/08 , C07D239/26 , C07D241/04 , C07D487/04 , C07K5/06104 , C07K5/06147
摘要： The present invention relates to medicine and includes a method for preventing and treating diseases caused by RNA- and DNA-containing viruses, and concomitant diseases, wherein the method comprises the use of an effective amount of compounds of general formula I or pharmaceutically acceptable salts thereof. The invention also relates to methods for preparing said compounds, pharmaceutical compositions for the prevention or treatment of diseases caused by RNA- and DNA-containing viruses, said compositions comprising an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof. The invention addresses the object of providing a novel agent effective in the treatment of diseases caused by an RNA-containing virus belonging to the Enterovirus, Metapneumovirus, Pneumovirus, Respirovirus, or Alfa-coronavirus genus, and/or by a DNA-containing virus belonging to the Adenoviridae and/or Herpesviridae family, and in the prevention and treatment of asthma exacerbation, chronic obstructive pulmonary disease, mucoviscidosis, conjunctivitis, gastroenteritis, hepatitis, myocarditis; in the prevention and treatment of rhinorrhea, acute and infectious rhinitis, pharyngitis, nasopharyngitis, tonsillitis, laryngitis, laryngotracheitis, laryngotracheobronchitis, bronchitis, bronchiolitis, pneumonia, or airway obstructive syndrome.
摘要翻译：本发明涉及药物，并且包括预防和治疗由含有RNA和DNA的病毒引起的疾病以及伴随疾病的方法，其中所述方法包括使用有效量的通式I的化合物或其药学上可接受的盐。本发明还涉及制备所述化合物的方法，用于预防或治疗由含RNA和DNA的病毒引起的疾病的药物组合物，所述组合物包含有效量的式I化合物或其药学上可接受的盐。本发明的目的在于提供一种有效治疗由属于肠道病毒，偏肺病毒，肺病毒，呼吸道病毒或阿尔法 - 冠状病毒属的含RNA病毒引起的疾病和/或所属的含有DNA的病毒腺病毒科和/或疱疹病毒科，以及用于预防和治疗哮喘恶化，慢性阻塞性肺病，粘膜粘连病，结膜炎，胃肠炎，肝炎，心肌炎; 在鼻炎，急性和感染性鼻炎，咽炎，鼻咽炎，扁桃体炎，喉炎，喉气管炎，喉气管支气管炎，支气管炎，毛细支气管炎，肺炎或气道阻塞综合征的预防和治疗中。

2. 发明授权

EP2476701B1 ANTIMICROBIAL AGENTS BASED ON HEMIN DERIVATIVES 有权
标题翻译：基于对衍生品和民抗微生物剂
公开(公告)号：EP2476701B1
公开(公告)日：2014-08-13
申请号：EP10815682.9
申请日：2010-09-08
申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
发明人： NEBOLSIN, Vladimir Evgenievich , ZHELTUKHINA, Galina Alexandrovna
IPC分类号： C07K14/805 , C07D487/22 , C07F15/02 , A61K38/42 , A61P31/04 , A61P31/10
CPC分类号： C07D487/22 , A61K31/555 , A61K38/00 , C07F15/025 , C07K14/795 , C07K14/805

3. 发明公开

EP3069720A8 PHARMACEUTICAL COMPOSITION CONTAINING GLUTARIMIDE DERIVATIVES, AND APPLICATION THEREOF FOR TREATING EOSINOPHILIC DISEASES 有权转让
标题翻译：含谷氨酰胺衍生物的药物组合物及其在治疗嗜酸性疾病中的应用
公开(公告)号：EP3069720A8
公开(公告)日：2017-10-04
申请号：EP14861410.0
申请日：2014-11-12
申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
发明人： NEBOLSIN, Vladimir Evgenievich , KROMOVA, Tatyana Alexandrovna , RYDLOVSKAYA, Anastasia Vladimirovna , CHUCHALIN, Alexander Grigorievich
IPC分类号： A61K31/45 , A61K31/454 , C07D211/88 , A61K47/00 , A61P37/08 , A61P11/00 , A61P1/00
摘要： The present invention relates to novel biologically active glutarimide derivatives of general formula (I) or a pharmaceutically acceptable salt thereof, their use as a therapeutic agent for the treatment of eosinophilic diseases, preferably of allergic nature, in particular bronchial asthma, allergic rhinitis, polypous rhinosinusopathies, eosinophilic colitis, eosinophilic syndrome, allergic conjunctivitis, atopic dermatitis, Churg-Strauss syndrome, anaphylactic shock, Quincke's edema, eosinophilic vasculitis, eosinophylic esophagitis, eosinophilic gastroenteritis, or fibroses. The invention also relates to pharmaceutical compositions comprising glutarimide derivatives of general formula (I):
摘要翻译：本发明涉及通式（I）的新型生物活性戊二酰亚胺衍生物或其药学上可接受的盐，它们作为治疗嗜酸性粒细胞性疾病，优选变应性性质，特别是支气管哮喘，变应性鼻炎，多发性嗜酸细胞性结肠炎，嗜酸性粒细胞综合征，变应性结膜炎，特应性皮炎，Churg-Strauss综合征，过敏性休克，Quincke水肿，嗜酸性粒细胞性血管炎，嗜酸性食管炎，嗜酸性胃肠炎或纤维化。本发明还涉及包含通式（I）的戊二酰亚胺衍生物的药物组合物：

4. 发明公开

EP2476701A1 ANTIMICROBIAL AGENTS BASED ON HEMIN DERIVATIVES 有权
标题翻译： ANTIMIKROBIELLE MITTEL AUF基于VON HEMIN-DERIVATEN
公开(公告)号：EP2476701A1
公开(公告)日：2012-07-18
申请号：EP10815682.9
申请日：2010-09-08
申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
发明人： NEBOLSIN, Vladimir Evgenievich , ZHELTUKHINA, Galina Alexandrovna
IPC分类号： C07K14/805 , C07D487/22 , C07F15/02 , A61K38/42 , A61P31/04 , A61P31/10
CPC分类号： C07D487/22 , A61K31/555 , A61K38/00 , C07F15/025 , C07K14/795 , C07K14/805
摘要： The invention relates to novel antimicrobial, including antibacterial and antifungal, agents and compositions based on hemin derivatives of general formula (I), and also to the production of novel hemin derivatives. The advantages of antibacterial agents based on hemin derivatives are their biocompatibility, biodegradability, high effectiveness against resistant bacteria and widespread microfungi that are harmful to humans, and freedom from toxicity and side effects.
摘要翻译：本发明涉及新型抗菌剂，包括抗菌和抗真菌剂，基于通式（I）的血红素衍生物的试剂和组合物，以及新型海明明衍生物的生产。基于血红素衍生物的抗菌剂的优点是其对人体有害的抗菌细菌和广泛的微生物的生物相容性，生物降解性，高效性，无毒副作用。

5. 发明公开

EP3632433A1 NOVEL GLUTAMINYL CYCLASE INHIBITORS AND THE USE THEREOF IN TREATMENT OF VARIOUS DISEASES 审中-实审转让
公开(公告)号：EP3632433A1
公开(公告)日：2020-04-08
申请号：EP18806314.3
申请日：2018-05-24
申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
发明人： NEBOLSIN, Vladimir Evgenievich , RYDLOVSKAYA, Anastasia Vladimirovna , KROMOVA, Tatyana Alexandrovna
IPC分类号： A61K31/4178 , A61K47/00
摘要： The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness and pain syndrome, and also other diseases by using compounds of formula (A)

wherein
R 1 is -C(O)-R 2 -C(O)- or -R 2 -C(O)- group, where R 2 is -(CH 2 ) n -group optionally substituted with one or two C 1 -C 6 alkyls, or phenyl,
n is an integer from 0 to 4;
wherein compounds are selected from the group consisting of the group of compounds as set out in the description. These compounds, as well as pharmaceutically acceptable salts thereof, are highly effective in inhibiting glutaminyl cyclase, which is involved, in particular, in processes of post-translational modification of chemokines and chemotaxis of monocytes, macrophages and other cells of the immune system. This invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of the compounds of formula (A) as defined above.

7. 发明授权

EP2893936B1 GLUTARYL HISTAMINE FOR THE TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY (+)RNA-CONTAINING VIRUSES 有权转让
标题翻译：用于治疗和预防由（+）含RNA病毒引起的疾病的谷氨酰胺组胺病
公开(公告)号：EP2893936B1
公开(公告)日：2018-04-04
申请号：EP13833080.8
申请日：2013-08-29
申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
发明人： NEBOLSIN, Vladimir Evgenievich , BORISEVICH, Sergei Vladimirovich , EGOROV, Andrei Yurievich
IPC分类号： A61K31/417 , A61K38/05 , A61P31/14 , A61P31/16
CPC分类号： A61K31/417 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/395
摘要： The invention relates to medicine and concerns a method for the prophylaxis or treatment of diseases caused by (+)RNA-containing viruses which involves the use of an effective amount of glutaryl histamine or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition for the prophylaxis or treatment of diseases caused by (+)RNA-containing viruses which contains an effective amount of glutaryl histamine or a pharmaceutically acceptable salt thereof. The present invention solves the problem of providing a novel agent which is effective in the treatment of diseases caused by (+)RNA-containing viruses of the enterovirus genus or of the flavivirus genus.

8. 发明公开

EP2826486A1 AGENT FOR THE TREATMENT OF HEPATITIS C VIRUS 审中-公开
标题翻译：治疗丙型肝炎病毒的代理商
公开(公告)号：EP2826486A1
公开(公告)日：2015-01-21
申请号：EP13760922.8
申请日：2013-03-13
申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
发明人： NEBOLSIN, Vladimir Evgenievich , KONSTANTINOV, Dmitry Yurievich , POPOVA, Larisa Leonidovna , STREBKOVA, Elena Alekseevna , DERYABIN, Petr Grigorievich
IPC分类号： A61K38/05 , A61K39/39 , A61P1/16 , A61P31/14
CPC分类号： A61K31/417 , A61K31/7056 , A61K38/05 , A61K38/21 , A61K38/212 , A61K2300/00
摘要： The invention relates to medicine and comprises an agent for the treatment of a viral hepatitis C, which is glutaryl histamine or a pharmaceutically acceptable salt thereof. This agent can also be administered in combination with a pegylated interferon and ribavirin. The invention further relates to a pharmaceutical composition for the treatment of a viral hepatitis C. This invention solves the problem of providing a novel agent, which is effective in the treatment of a viral hepatitis C and makes it possible to produce a sustained virologic response.
摘要翻译：本发明涉及药物并且包含用于治疗病毒性丙型肝炎的药剂，其是戊二酰组胺或其药学上可接受的盐。该药剂还可以与聚乙二醇化干扰素和利巴韦林联合给药。本发明进一步涉及用于治疗病毒性丙型肝炎的药物组合物。本发明解决了提供新型药物的问题，该药物可有效治疗病毒性丙型肝炎，并使其有可能产生持续的病毒学应答。

9. 发明授权

EP2476701B8 ANTIMICROBIAL AGENTS BASED ON HEMIN DERIVATIVES 有权
标题翻译：基于对衍生品和民抗微生物剂
公开(公告)号：EP2476701B8
公开(公告)日：2014-09-24
申请号：EP10815682.9
申请日：2010-09-08
申请人： Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises"
发明人： NEBOLSIN, Vladimir Evgenievich , ZHELTUKHINA, Galina Alexandrovna
IPC分类号： C07K14/805 , C07D487/22 , C07F15/02 , A61K38/42 , A61P31/04 , A61P31/10
CPC分类号： C07D487/22 , A61K31/555 , A61K38/00 , C07F15/025 , C07K14/795 , C07K14/805

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