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1. 发明公开

EP1391462A1 CROHN'S DISEASE ANTIBODY-BINDING PEPTIDE AND METHOD OF EXAMINING CROHN'S DISEASE 审中-公开
标题翻译：肽抗体反对克罗恩病的关系，和方法的克隆氏病的考试
公开(公告)号：EP1391462A1
公开(公告)日：2004-02-25
申请号：EP02722733.9
申请日：2002-04-24
申请人： OTSUKA PHARMACEUTICAL CO., LTD.
发明人： SAITO, Hiroshi , KATSURAGI, Kiyonori , TACHIKAWA, Tetsuya , TANAKA, Michinori , OGINO, Koichi , TAKI, Takao
IPC分类号： C07K7/06 , C07K7/08 , C07K14/415 , C07K14/47 , G01N33/53
CPC分类号： G01N33/564 , C07K14/415 , C07K14/4713
摘要： The invention provides that examination reagents useful in diagnosing Crohn's disease and a method of conveniently and accurately detecting the occurrence of Crohn's disease. The examination reagents contain as the active ingredient a Crohn's disease antibody-binding protein as defined in the following (a) or (b): (a) a peptide consisting of an amino acid sequence selected from among the amino acid sequences represented by SEQ ID NOS:1 to 4; and (b) a peptide consisting of an amino acid sequence derived from the above-mentioned amino acid sequence (a) by substitution, deletion or addition of one to several amino acids and being capable of binding to the Crohn's disease antibody. The examination method can be carried out by detecting the presence/absence of an antibody recognizing human vacuolar H + -transport ATPase, a human nuclear protein (Homo sapiens kruppel-like zinc finger protein 300) or rice allergen in a biological sample of a subject.
摘要翻译：本发明提供了确实的诊断克罗恩病和方便，准确地设置检测克罗恩病的发生的方法有用的检查试剂。检查试剂包含克隆氏病抗体结合蛋白作为活性成分的如所定义的以下（a）或（b）：（a）一种肽由选自由SEQ ID表示的氨基酸序列中的氨基酸序列的 NOS：1至4; 和（b）由从通过取代，缺失或添加一个或数个氨基酸和能够结合到克隆氏病抗体的上述氨基酸序列的（a）衍生的氨基酸序列组成的肽。的生物样品中的运输ATP酶，人核蛋白（智人残废样锌指蛋白300）或稻的变应原 - 的检查方法可以通过检测存在/不存在的抗体识别人液泡H <+>来开展一个主题。

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