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1. 发明公开

EP2618151A1 Low volume assay device having increased sensitivity 有权
标题翻译： Niedermengen-Analysevorrichtung mit gesteigerter Empfindlichkeit
公开(公告)号：EP2618151A1
公开(公告)日：2013-07-24
申请号：EP13151783.1
申请日：2013-01-18
申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： Hosimer, Philip C. , Ding, Zhong , Heavner, David A. , Scalice, Edward R. , Danielson, Susan , Kanaley, James D. , Tomasso, David A. , Warren, Timothy C.
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/558 , G01N33/54386
摘要： An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample addition zone containing a reagent material; a detection zone in fluid communication with the reagent zone. The detection zone has a substrate and projections which extend substantially vertically from the substrate, wherein the projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface. The device is capable of creating a reagent plume in the detection zone that includes liquid sample and dissolved reagent, where the width of the reagent plume extends substantially across the width of the detection zone, The device further includes a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone.
摘要翻译：测定装置包括：液体样品区; 下游的试剂区并与含有试剂材料的样品添加区流体连通; 与试剂区流体连通的检测区域。检测区域具有基板和从基板基本上垂直延伸的突起，其中突起具有彼此之间的高度，横截面和距离，其限定了能够产生平行于基板表面的毛细管流动的突起之间的毛细管空间。该装置能够在检测区域中产生包含液体样品和溶解试剂的试剂羽流，其中试剂羽流的宽度基本上延伸穿过检测区域的宽度。该装置还包括与该检测区流体连通的芯吸区域检测区具有接收从检测区流出的液体样品的能力。

2. 发明授权

EP2618151B1 Low volume assay device having increased sensitivity 有权
标题翻译：较低量的分析仪具有增加的灵敏度
公开(公告)号：EP2618151B1
公开(公告)日：2016-07-20
申请号：EP13151783.1
申请日：2013-01-18
申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： Hosimer, Philip C. , Ding, Zhong , Heavner, David A. , Scalice, Edward R. , Danielson, Susan , Kanaley, James D. , Tomasso, David A. , Warren, Timothy C.
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/558 , G01N33/54386

3. 发明公开

EP2811301A1 Quality/process control of a lateral flow assay device based on flow monitoring 有权
标题翻译： Qualitäts-/ Prozesssteuerung einer Lateralflusstestvorrichtung auf Grundlage vonFlussüberwachung
公开(公告)号：EP2811301A1
公开(公告)日：2014-12-10
申请号：EP13192854.1
申请日：2013-11-14
申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： Heavner, David A. , Tomasso, David A. , Robinson, James E. , Ding, Zhong
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , B01L3/5023 , B01L2200/143 , B01L2300/0861 , B01L2400/0406 , G01N21/6428 , G01N33/5302 , G01N33/54366 , G01N2021/6439
摘要： A method for providing quality control on a lateral flow assay device or for triggering a process-related step, the device including a substrate having at least one sample receiving area, at least one reagent zone downstream and in fluid communication with the at least one sample receiving area, at least one detection zone downstream and in fluid communication with the at least one reagent zone and at least one wicking zone downstream of the at least one detection zone, each fluidly interconnected therewith along at least one fluid flow path. The detection material provided in the at least one reagent zone produces a detectable signal that can be tracked and monitored prior to the completion of at least one test being performed on the lateral flow assay device.
摘要翻译：一种用于在侧流测定装置上提供质量控制或用于触发过程相关步骤的方法，所述装置包括具有至少一个样品接收区域的底物，下游的至少一个试剂区域和与所述至少一个样品流体连通接收区域，下游的至少一个检测区域以及与所述至少一个试剂区域流体连通的至少一个检测区域和在所述至少一个检测区域下游的至少一个芯吸区域，每个检测区域沿着至少一个流体流动路径流体地互连。提供在至少一个试剂区域中的检测材料产生可检测的信号，其可以在完成在侧流测定装置上进行的至少一次测试之前被跟踪和监测。

4. 发明授权

EP2811301B1 Quality/process control of a lateral flow assay device based on flow monitoring 有权
标题翻译：基于流量监测的侧流测定装置的质量/过程控制
公开(公告)号：EP2811301B1
公开(公告)日：2017-05-10
申请号：EP13192854.1
申请日：2013-11-14
申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： Heavner, David A. , Tomasso, David A. , Robinson, James E. , Ding, Zhong
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , B01L3/5023 , B01L2200/143 , B01L2300/0861 , B01L2400/0406 , G01N21/6428 , G01N33/5302 , G01N33/54366 , G01N2021/6439

5. 发明公开

EP2147723A1 Use of fluid aspiration/dispensing tip as a microcentrifuge tube 审中-公开
标题翻译：使用尖端到流体抽吸bzw.abgabe微离心机容器
公开(公告)号：EP2147723A1
公开(公告)日：2010-01-27
申请号：EP09251798.6
申请日：2009-07-15
申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： Heavner, David A.
IPC分类号： B01L3/02 , B01L3/14
CPC分类号： B01L3/0275 , B01L3/5021 , B01L3/5025 , B01L2300/042 , B01L2300/0829 , B01L2400/0409 , B01L2400/0487 , G01N2035/0434 , Y10T436/25375 , Y10T436/2575
摘要： A fluid aspirating/dispensing member (100) includes a sample cavity (106) for sample acquisition and a sealable cavity (110) that, once sealed, permits the separation of particles from the remainder of a fluid sample within the sample cavity (106) after centrifugation or other separation means. The fluid aspirating/dispensing members (100), either individually or as part of an array, increase the efficiency of sample processing before analysis by a clinical analyzer.
摘要翻译：流体抽吸/分配构件（100）包括用于样品采集和可密封的腔（110），一旦密封的样品腔（106），允许从流体样品的样品腔中的剩余颗粒的分离（106）离心或其他分离装置之后。流体抽吸/分配构件（100）单独地或作为阵列的一部分，由一个临床分析仪样品增加的处理之前分析的效率。

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