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1. 发明公开

EP0608117A2 Antibodies for mevalonic acid and methods for determination of mevalonic acid 失效
标题翻译： AntikörpergegenMevaloniksäureund Verfahren zur Bestimmung vonMevaloniksäure。
公开(公告)号：EP0608117A2
公开(公告)日：1994-07-27
申请号：EP94300374.9
申请日：1994-01-19
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Hayashi, Akio, c/o Minase Research Institute , Hiramatsu, Makoto, c/o Minase Research Institute , Hamanaka, Nobuyuki, c/o Minase Research Institute
IPC分类号： C12P21/08 , G01N33/53 , C12N15/06 , G01N33/536 , G01N33/543
CPC分类号： C07K16/18
摘要： Polyclonal and monoclonal antibodies are obtained specific to mevalonic acid, having low cross-reactivity with mevalonic acid analogues, such as glutaric acid, 3-methylglutaric acid and 3-hydroxy-3-methylglutaric acid. The antibodies may be used for determination of mevalonic acid providing an immunoassay excellent in sensitivity, specificity and reproducibility.
摘要翻译：对甲羟戊酸具有特异性的多克隆和单克隆抗体，与甲羟戊酸类似物如戊二酸，3-甲基戊二酸和3-羟基-3-甲基戊二酸具有低交叉反应性。抗体可用于测定甲羟戊酸，提供灵敏度，特异性和重现性优异的免疫测定。

4. 发明公开

EP0608117A3 Antibodies for mevalonic acid and methods for determination of mevalonic acid 失效
标题翻译：用于测定甲酸的抗体及其测定方法。
公开(公告)号：EP0608117A3
公开(公告)日：1996-01-17
申请号：EP94300374.9
申请日：1994-01-19
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Hayashi, Akio, c/o Minase Research Institute , Hiramatsu, Makoto, c/o Minase Research Institute , Hamanaka, Nobuyuki, c/o Minase Research Institute
IPC分类号： C12P21/08 , G01N33/53 , C12N15/06 , G01N33/536 , G01N33/543
CPC分类号： C07K16/18
摘要： Polyclonal and monoclonal antibodies are obtained specific to mevalonic acid, having low cross-reactivity with mevalonic acid analogues, such as glutaric acid, 3-methylglutaric acid and 3-hydroxy-3-methylglutaric acid. The antibodies may be used for determination of mevalonic acid providing an immunoassay excellent in sensitivity, specificity and reproducibility.

5. 发明公开

EP0619296A1 Phenylalkan(en)oic acids with leukotriene B4 antagonistic activity 失效
标题翻译：苯扎林（en）-Säurenmit白介素B4拮抗剂Wirkung。
公开(公告)号：EP0619296A1
公开(公告)日：1994-10-12
申请号：EP94108324.8
申请日：1990-05-16
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Konno, Mitoshi, c/o Minase Research Institute , Nakae, Takahiko, c/o Minase Research Institute , Hamanaka, Nobuyuki, c/o Minase Research Institute
IPC分类号： C07C233/81 , C07C235/42 , C07C311/21 , C07C311/13 , A61K31/165 , A61K31/18
CPC分类号： C07C69/734 , C07C59/52 , C07C59/64 , C07C59/68 , C07C59/90 , C07C205/34 , C07C205/56 , C07C233/47 , C07C233/54 , C07C233/81 , C07C235/16 , C07C235/20 , C07C235/34 , C07C235/42 , C07C235/78 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/51 , C07C323/19 , C07C405/0066 , C07C2601/14 , C07D207/27 , C07D209/08 , C07D209/48 , C07D275/03 , C07D277/42 , C07D277/46 , C07D279/02 , C07D295/185
摘要： The phenylalkan(en)oic acids of the formula:

wherein

A is

i) -NHCO- or
ii) -NHSO₂-;

W is

i) phenylene or
ii)

R¹ is

i) hydrogen,
ii) C1-4 alkyl,
iii) -COOH,
iv) saturated or unsaturated, 4-7 membered mono-cyclic hetero ring containing one nitrogen as a hetero atom or saturated or unsaturated, 4-7 membered mono-cyclic hetero ring containing one nitrogen as a hetero atom substituted by an oxo group,
v)

vi) -CH₂OH;

two R² are, same or different,

i) hydrogen,
ii) C1-4 alkyl or
iii) 4-7 membered, saturated or unsaturated, mono-cyclic hetero ring containing two or three of nitrogen and sulfur in total,
or two R², taken together with a nitrogen to which they are attached, form saturated or unsaturated,

i) 7-14 membered, bi- or tri-cyclic hetero ring containing one nitrogen as a hetero atom, or
ii) 4-7 membered, mono-cyclic hetero ring containing two or three of nitrogen and oxygen in total;

Y is ethylene or vinylene;
D is

i) -Z-B or
ii)

Z is C3-11 alkylene or alkenylene;
B is
or
Z, taken together with B, is C3-22 alkyl;
R³ is

i) hydrogen,
ii) halogen,
iii) C1-8 alkyl, alkoxy or alkylthio, or
iv) C2-8 alkenyl, alkenyloxy or alkenylthio;

n is 1-3;
R⁴ is C1-7 alkylene;
R⁵ is

i) C1-12 alkyl,
ii) C2-12 alkenyl,
iii) C5-7 cycloalkyl or
iv) phenethyl or phenethyl wherein the ring is substituted by one C1-4 alkoxy;

with the proviso that -A-W-R¹ should bind to 3- or 4- carbon in benzene ring; and non-toxic salts thereof,
possess an antagonism on leukotriene B₄, and therefore, are useful for the prevention and treatment of several diseases induced by leukotriene B₄.
摘要翻译：下式的苯烷（en）酸：其中A是i）-NHCO-或ii）-NHSO 2; W是i）亚苯基或ii）CH 2 R 1是i）氢，ii）C 1-4烷基，iii）-COOH，iv）饱和或不饱和的含有一个氮的4-7元单环杂环作为杂环原子或饱和或不饱和的4-7元单环杂环，其含有一个氮原子作为被氧基取代的杂原子，v） vi）-CH 2 OH; 两个R 2相同或不同，i）氢，ii）C 1-4烷基或iii）4-7元饱和或不饱和的单环杂环，其总共含有两个或三个氮和硫，或两个R 2与它们所连接的氮一起形成饱和或不饱和的，i）含有一个氮作为杂原子的7-14元，双或三环杂环，或ii）4- 总共含有两个或三个氮和氧的7元单环杂环; Y是乙烯或亚乙烯基; D是i）-Z-B或ii） Z是C3-11亚烷基或亚烯基; B为或Z与B一起为C3-22烷基; R 3是i）氢，ii）卤素，iii）C 1-8烷基，烷氧基或烷硫基，或iv）C 2-8烯基，烯氧基或烯硫基; n为1-3; R 4是C 1-7亚烷基; R 5是i）C 1-12烷基，ii）C 2-12烯基，iii）C 5-7环烷基或iv）苯乙基或苯乙基，其中该环被一个C 1-4烷氧基取代; 条件是-A-W-R 1应结合苯环中的3-或4-碳; 及其无毒盐对白三烯B4具有拮抗作用，因此可用于预防和治疗白三烯B4诱导的几种疾病。

6. 发明公开

EP0405116A2 Phenylalkan(en)oic acids 失效
标题翻译： Phenylalkan（EN）säuren。
公开(公告)号：EP0405116A2
公开(公告)日：1991-01-02
申请号：EP90109294.0
申请日：1990-05-16
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Konno, Mitoshi, c/o Minase Research Institute , Nakae, Takahiko, c/o Minase Research Institute , Hamanaka, Nobuyuki, c/o Minase Research Institute
IPC分类号： C07C235/74 , C07C233/54 , C07C59/68 , C07C235/06 , C07C311/08 , C07C235/34 , C07C235/78 , C07C59/64 , C07D279/02 , C07D209/48 , C07D275/03
CPC分类号： C07C69/734 , C07C59/52 , C07C59/64 , C07C59/68 , C07C59/90 , C07C205/34 , C07C205/56 , C07C233/47 , C07C233/54 , C07C233/81 , C07C235/16 , C07C235/20 , C07C235/34 , C07C235/42 , C07C235/78 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/51 , C07C323/19 , C07C405/0066 , C07C2601/14 , C07D207/27 , C07D209/08 , C07D209/48 , C07D275/03 , C07D277/42 , C07D277/46 , C07D279/02 , C07D295/185
摘要： The phenylalkan(en)oic acids of the formula:
wherein the substituants are defined as in the disclosure, possess an antagonism on leukotriene B 4 , and therefore, are useful for the prevention and treatment of several diseases induced by leukotriene B 4 .
摘要翻译：下式的苯烷（en）酸：其中取代基如本公开内容所定义，具有对白三烯B4的拮抗作用，因此可用于预防和治疗由白三烯B4诱导的几种疾病。

7. 发明授权

EP0578847B1 Fused benzeneoxyacetic acid derivatives and their use as PG12 antagonists 失效
标题翻译：熔点苯氧乙酸衍生物及其作为PG12拮抗剂的用途
公开(公告)号：EP0578847B1
公开(公告)日：1996-10-09
申请号：EP92111988.9
申请日：1992-07-14
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Hamanaka, Nobuyuki, c/o Minase Research Institute , Takahashi, Kanji, c/o Minase Research Institute , Tokumoto, Hidekado, c/o Minase Research Institute
IPC分类号： C07C251/42 , C07C251/40 , C07C251/48 , A61K31/00
CPC分类号： C07C251/42 , C07C59/72 , C07C69/712 , C07C239/20 , C07C251/40 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/14 , C07C2602/10 , C07C2602/12 , C07C2603/18 , C07C2603/32

8. 发明公开

EP0578847A1 Fused benzeneoxyacetic acid derivatives and their use as PG12 antagonists 失效
标题翻译：熔点苯氧乙酸衍生物及其作为PG12拮抗剂的用途
公开(公告)号：EP0578847A1
公开(公告)日：1994-01-19
申请号：EP92111988.9
申请日：1992-07-14
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Hamanaka, Nobuyuki, c/o Minase Research Institute , Takahashi, Kanji, c/o Minase Research Institute , Tokumoto, Hidekado, c/o Minase Research Institute
IPC分类号： C07C251/42 , C07C251/40 , C07C251/48 , A61K31/00
CPC分类号： C07C251/42 , C07C59/72 , C07C69/712 , C07C239/20 , C07C251/40 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/14 , C07C2602/10 , C07C2602/12 , C07C2603/18 , C07C2603/32
摘要： A fused benzeneoxyacetic acid derivative of the formula:

wherein

is

(i)

(ii)

(iii)
or
(iv)

A is

(i)
or
(ii)

R¹ is hydrogen or C₁₋₄ alkyl;
R² is hydrogen, C₁₋₆ alkyl or phenyl;
R³ is

(i) C₁₋₁₅ alkyl,
(ii) C₁₋₈ alkyl substituted by one or two of benzene, C₄₋₇ cycloalkane or 4-7 ring-membered monocyclic ring which contains one nitrogen atom or
(iii) C₁₀₋₁₅ condensed tricyclic ring;

e is 3-5;
f is 1-3;
p is 0-4;
q is 0-2;
s is 0-3
With the proviso that, ring(s) in R³ may be substituted by one to three of C₁₋₄ alkyl, ₁₋₄ alkoxy, halogen atom, nitro or trihalomethyl. And, when D -- ¯ B is the formula (iii) or (iv), -(CH2)p- or =CH-(CH2)s- is attached at the position of a or b on the ring.
and non-toxic salts thereof possess an antagonistic activity on PGI2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension.
摘要翻译：（ⅰ）（ⅱ）（ⅲ）或（））A是（ⅰ）或（ⅱ）R 1是氢或C 1-4烷基的稠合苯氧基乙酸衍生物， R 2是氢，C 1-6烷基或苯基; R 3是（ⅰ）C 1-15烷基，（ⅱ）被一个或两个苯，C 4-8环烷烃或含有一个氮原子的4-7元环单环取代的C 1-8烷基，或（ⅲ）C 10-15 稠合三环; e是3-5; f是1-3; p是0-4; q是0-2; s为0-3条件是R 3中的环可以被1-3个C 1-4烷基，C 1-4烷氧基，卤素原子，硝基或三卤代甲基取代。并且，当D - B是式（iii）或（iv）时， - （CH 2）p - 或= CH-（CH 2）s - 连接在环上a或b的位置。及其无毒盐对PGI2受体具有拮抗活性，因此可用于预防和/或治疗血栓形成，动脉硬化，缺血性心脏病，胃溃疡和高血压。

9. 发明公开

EP0405116A3 Phenylalkan(en)oic acids 失效
标题翻译：苯基烷（烯）酸
公开(公告)号：EP0405116A3
公开(公告)日：1992-04-15
申请号：EP90109294.0
申请日：1990-05-16
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Konno, Mitoshi, c/o Minase Research Institute , Nakae, Takahiko, c/o Minase Research Institute , Hamanaka, Nobuyuki, c/o Minase Research Institute
IPC分类号： C07C235/74 , C07C233/54 , C07C59/68 , C07C235/06 , C07C311/08 , C07C235/34 , C07C235/78 , C07C59/64 , C07D279/02 , C07D209/48 , C07D275/03
CPC分类号： C07C69/734 , C07C59/52 , C07C59/64 , C07C59/68 , C07C59/90 , C07C205/34 , C07C205/56 , C07C233/47 , C07C233/54 , C07C233/81 , C07C235/16 , C07C235/20 , C07C235/34 , C07C235/42 , C07C235/78 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/51 , C07C323/19 , C07C405/0066 , C07C2601/14 , C07D207/27 , C07D209/08 , C07D209/48 , C07D275/03 , C07D277/42 , C07D277/46 , C07D279/02 , C07D295/185
摘要： The phenylalkan(en)oic acids of the formula:
wherein the substituants are defined as in the disclosure, possess an antagonism on leukotriene B 4 , and therefore, are useful for the prevention and treatment of several diseases induced by leukotriene B 4 .
摘要翻译：下式的苯基烷烃（烯）酸：其中取代基如本发明所定义，对白三烯B4具有拮抗作用，因此可用于预防和治疗由白三烯B4诱导的几种疾病。

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