专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP1761533B1 1-AZA-BICYCLO[3.3.1]NONANES 失效转让
标题翻译： 1-氮杂 - 二环[3.3.1]壬烷
公开(公告)号：EP1761533B1
公开(公告)日：2011-04-20
申请号：EP05771214.3
申请日：2005-06-17
申请人： Novartis AG
发明人： FEUERBACH, Dominik , MÜLLER, Werner , ROY, Bernard, Lucien , TROXLER, Thomas, J. , HURTH, Konstanze , FREDERIKSEN, Mathias
IPC分类号： C07D471/04 , A61K31/439 , A61P25/00
CPC分类号： C07D471/08
摘要： The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I); wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. Formula (I), wherein A represents O or N(R1); Y represents a group of formula, or wherein the left bond is attached to the A group and the right bond is attached to the R group; R represents a substituted or unsubstituted C5- C10aryl, substituted or unsubstituted hetero-C5-C10aryl, a group N(R1)(R4), or a group N(R2)(CHP3R4); R represent a hydrogen, C1-C4alkyl, or CF3; R2 represents hydrogen, C1-C4alkyl, or CF3; R3 represents hydrogen, C1-C4alkyl, or CF3; R4 represents a substituted or unsubstituted C5-C10 aryl or a substituted or unsubstituted C5-C10heteroaryl; in free base or acid addition salt form.
摘要翻译：本发明涉及式（I）的1-氮杂 - 二环烷基衍生物; 其中取代基如说明书中所定义，涉及其制备方法，其作为药物的用途以及包含它们的药物组合物。式（I），其中A代表O或N（R1）; Y代表式的基团，或者其中左键连接至A基团并且右键连接至R基团; R代表取代或未取代的C 5 -C 10芳基，取代或未取代的杂-C 5 -C 10芳基，基团N（R 1）（R 4）或基团N（R 2）（CHP 3 R 4）。 R代表氢，C 1 -C 4烷基或CF 3; R2代表氢，C1-C4烷基或CF3; R3代表氢，C1-C4烷基或CF3; R4代表取代或未取代的C5-C10芳基或取代或未取代的C5-C10杂芳基; 以游离碱或酸加成盐形式。

2. 发明公开

EP1753719A1 SUBSTITUTED PYRROLIDINE-2-ONES 有权
标题翻译：取代的吡咯烷-2-酮
公开(公告)号：EP1753719A1
公开(公告)日：2007-02-21
申请号：EP05749343.9
申请日：2005-05-27
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： MÜLLER, Werner , NOZULAK, Joachim , ROY, Bernard, Lucien , FEUERBACH, Dominik
IPC分类号： C07D207/22 , C07D401/06 , C07D403/04 , C07D405/04 , C07D417/04 , C07D409/10 , C07D407/10 , A61K31/44 , A61P25/00 , C07D409/14 , C07D417/14
CPC分类号： C07D207/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and n are as defined in the specification, to processes for their manufacture, to their use as pharmaceuticals, in diagnosis, as PET ligands and to pharmaceutical or diagnostic compositions comprising such compounds.

3. 发明授权

EP1761533B8 1-AZA-BICYCLO[3.3.1]NONANES 失效转让
标题翻译： 1-氮杂 - 二环[3.3.1]壬烷
公开(公告)号：EP1761533B8
公开(公告)日：2011-10-12
申请号：EP05771214.3
申请日：2005-06-17
申请人： Novartis AG
发明人： FEUERBACH, Dominik , MÜLLER, Werner , ROY, Bernard, Lucien , TROXLER, Thomas, J. , HURTH, Konstanze , FREDERIKSEN, Mathias
IPC分类号： C07D471/04 , A61K31/439 , A61P25/00
CPC分类号： C07D471/08

4. 发明公开

EP1761533A1 1-AZA-BICYCLO[3.3.1]NONANES 失效转让
标题翻译： 1-氮杂 - 二环[3.3.1]壬烷
公开(公告)号：EP1761533A1
公开(公告)日：2007-03-14
申请号：EP05771214.3
申请日：2005-06-17
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： FEUERBACH, Dominik , MÜLLER, Werner , ROY, Bernard, Lucien , TROXLER, Thomas, J. , HURTH, Konstanze , FREDERIKSEN, Mathias
IPC分类号： C07D471/04 , A61K31/439 , A61P25/00
CPC分类号： C07D471/08
摘要： The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I); wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. Formula (I), wherein A represents O or N(R1); Y represents a group of formula, or wherein the left bond is attached to the A group and the right bond is attached to the R group; R represents a substituted or unsubstituted C5- C10aryl, substituted or unsubstituted hetero-C5-C10aryl, a group N(R1)(R4), or a group N(R2)(CHP3R4); R represent a hydrogen, C1-C4alkyl, or CF3; R2 represents hydrogen, C1-C4alkyl, or CF3; R3 represents hydrogen, C1-C4alkyl, or CF3; R4 represents a substituted or unsubstituted C5-C10 aryl or a substituted or unsubstituted C5-C10heteroaryl; in free base or acid addition salt form.

5. 发明授权

EP1753719B1 SUBSTITUTED PYRROLIDINE-2-ONES 有权
标题翻译：取代的吡咯烷-2-酮
公开(公告)号：EP1753719B1
公开(公告)日：2010-03-03
申请号：EP05749343.9
申请日：2005-05-27
申请人： Novartis AG
发明人： MÜLLER, Werner , NOZULAK, Joachim , ROY, Bernard, Lucien , FEUERBACH, Dominik
IPC分类号： C07D207/22 , C07D401/06 , C07D403/04 , C07D405/04 , C07D417/04 , C07D409/10 , C07D407/10 , A61K31/44 , A61P25/00 , C07D409/14 , C07D417/14
CPC分类号： C07D207/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and n are as defined in the specification, to processes for their manufacture, to their use as pharmaceuticals, in diagnosis, as PET ligands and to pharmaceutical or diagnostic compositions comprising such compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式