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    • 7. 发明公开
    • TARGETING MOLECULE AND UTILIZATION THEREOF
    • ZIELMOLEKÜLUND VERWENDUNG DAVON
    • EP3127915A1
    • 2017-02-08
    • EP15773773.5
    • 2015-04-01
    • Nitto Denko Corporation
    • MINOMI, KenjiroTAKAHASHI, HirokazuTERADA, ErikaNIITSU, Yoshiro
    • C07K14/47A61K38/00A61K49/00A61P35/00A61P43/00C12N15/09C12N15/113
    • Provided are: a targeting molecule targeting a target cell which is selected from the group consisting of a stellate cell, a myofibroblast, a cancer-associated fibroblast, a tumor cell and a cell expressing STRA6, said targeting molecule being selected from the group consisting of (1) a peptide containing an amino acid sequence in the cell-binding region of RBP, (2) a variant peptide of the aforesaid peptide (1), said variant peptide having a comparable targetability to peptide (1), and (3) a peptide mimetic having a comparable targetability to peptide (1) or peptide (2); a targeting agent, a carrier, a complex and a medicinal composition each comprising the targeting molecule; a method for treating, examining, diagnosing or monitoring a disease related to the aforesaid target cell; a method for labeling, detecting or imaging the target cell, etc.
    • 提供:靶向靶细胞的靶向分子,其选自星状细胞,肌成纤维细胞,癌相关成纤维细胞,肿瘤细胞和表达STRA6的细胞,所述靶向分子选自: (1)在RBP的细胞结合区域中含有氨基酸序列的肽,(2)上述肽(1)的变体肽,所述变体肽与肽(1)具有相当的靶向性,(3) 具有与肽(1)或肽(2)相当的靶向性的肽模拟物; 靶向剂,载体,复合物和药物组合物,各自包含靶向分子; 用于治疗,检查,诊断或监测与上述靶细胞有关的疾病的方法; 用于标记,检测或成像靶细胞的方法等